As of July 2024, the approved bispecific antibodies are used to treat multiple myeloma that has come back or stopped responding to other treatments (relapse and/or refractory disease). However, researchers are exploring if these powerful drugs can be used earlier in the disease.
Why might earlier treatment be beneficial?
Stopping cancer in its tracks: Treating myeloma sooner could potentially prevent it from spreading, becoming more aggressive, or irreversibly affecting other parts of the body.
Longer remissions: Early treatment might lead to longer periods of time without the disease returning.
Improved overall survival: By treating the myeloma early, patients may live longer.
While the idea of using bispecific antibodies earlier in treatment is exciting, there are challenges. These therapies can cause side effects, and finding the right dose, sequencing, and timing is crucial. Additionally, their high cost is a concern.
However, ongoing research is focused on overcoming these challenges. Scientists are testing different combinations of bispecific antibodies with other treatments to improve their effectiveness and reduce side effects. Some clinical trials with bispecific antibodies currently recruiting patients newly diagnosed with multiple myeloma are (July 2024):