What are the side effects of bispecific antibody therapy? When can I expect to experience these side effects?

Like any medication, bispecific antibodies can cause side effects. Understanding these potential side effects shouldn't deter you from exploring bispecific antibody therapy as a treatment option. However, it emphasizes the importance of discussing the potential benefits and risks with your doctor to determine if this therapy is right for you.

Bispecific antibody side effects can be categorized as early or late, depending on when they occur after initiating treatment.

Early Side Effects (occur soon after treatment initiation):

Cytokine Release Syndrome (CRS): This reaction mimics flu-like symptoms such as fever, chills, fatigue, and muscle aches. While concerning, CRS is typically manageable with medication and supportive care.

Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS): This can cause headaches, confusion, and even seizures. Early detection and treatment are important to minimize long-term effects.

  

Late Side Effects (develop weeks or months later):

Infections: Bispecific antibodies can weaken the immune system, making you more susceptible to infections.

 

Low blood cell counts (cytopenias): A decrease in red blood cells (anemia), white blood cells (neutropenia), or platelets (thrombocytopenia) can occur.

 

Neurological complications: While rare, some studies suggest a possibility of long-term neurological effects requiring ongoing investigation.

 

Bispecific antibody therapy is a relatively new approach. Doctors and regulatory bodies are actively researching the full range of potential side effects, particularly long-term effects. Regular checkups and open communication with your doctor are crucial for managing any side effects you might experience.