What is given to prevent CRS?

While in the step-up dosing phase, about 1-3 hours before your dose, you should receive the following pretreatment medications: 

     Corticosteroid (oral or intravenous dexamethasone 16 mg) 

     Histamine-1 (H1) receptor antagonist (oral or intravenous diphenhydramine 50 mg or equivalent)

     Antipyretics (oral or intravenous acetaminophen 650 mg to 1000 mg or equivalent) 

     Tocilizumab (a multi-use drug commonly used to treat arthritis) 

Patients who experienced CRS during their first dose of bispecific antibody or those who missed a dose in their regular schedule may need to take pretreatment medication before they receive their weekly doses. Additionally, patients who repeat doses within the step-up dosing schedule following a dose delay may also require pretreatment medication.