Muscle, joint, and bone pain are common for people living with myeloma, especially after CAR-T. There are several reasons why this can happen:

• Bone marrow involvement. Myeloma cells can collect in the bone marrow, causing pain in the bones and joints.
• Side effects from treatment. CAR-T can increase inflammation, leading to soreness in muscles and joints.
• Other health issues. Conditions like arthritis or osteoporosis may also cause joint or bone pain in people with myeloma.
• Fatigue. Tiredness from CAR-T or the cancer itself can sometimes lead to body aches and muscle discomfort.

How to manage pain after CAR-T for myeloma

There are several ways to reduce muscle, joint, or bone pain and improve comfort:

Medications

• Use over-the-counter pain relief like acetaminophen
• Prescription pain medicines or anti-inflammatory treatments may also help
• Bone-strengthening medications may be used if needed

Physical therapy and movement

• Try gentle stretches and exercises to improve strength and flexibility
• A physical therapist can show you safe movements to reduce pain and stiffness

Supportive therapies

• Use warm or cold packs to ease sore areas
• Make ergonomic changes at home, like using supportive chairs or cushions to protect your joints 

Complementary therapies

• Consider acupressure to relieve pain without medication
• Massage therapy can help relax tight muscles
• Try gentle mind-body practices like yoga, meditation, or breathing exercises
• Some people may benefit from magnesium supplements—talk to a registered dietitian before starting any new supplement 

Healthy habits

• Rest when your body needs it
• Drink plenty of water to stay hydrated

Reduce inflammation

• Eat more anti-inflammatory foods, like fruits, vegetables, nuts, and fish
• Light physical activity, when safe, may also help lower inflammation over time