After CAR T-cell therapy, some people with myeloma may experience stomach or digestive problems. These are often caused by a side effect called cytokine release syndrome (CRS), which happens when the immune system becomes very active after treatment.

These stomach-related side effects can usually be managed with medicine, diet changes, and supportive care. Always let your healthcare team know if you’re having any digestive issues so they can help you feel better.

How to manage digestive side effects after CAR-T for myeloma

Diarrhea

• Use anti-diarrhea medicine
• Drink fluids with added electrolytes (like sports drinks) to stay hydrated
• If you have more than seven episodes in one day, tell your doctor right away so they can test your stool for infection

Nausea and vomiting

• Use anti-nausea medicine (called antiemetics)
• Eat small meals throughout the day
• Avoid strong smells, which can make nausea worse
• If vomiting lasts more than two days for adults, contact your doctor

Constipation

• Use laxatives if needed
• Add more fiber to your meals (like fruits, vegetables, and whole grains)
• Drink plenty of water

Loss of appetite

• Try eating small, nutrient-dense meals
• Talk to your doctor about appetite-boosting medicine if you're not eating enough

Stomach pain or cramping

• Use over-the-counter pain relievers
• A warm heating pad on your stomach may help ease cramps

Stomach and digestive problems can happen after CAR T-cell therapy. They can usually be managed with help from your care team. Don’t hesitate to speak up about how you’re feeling; there are ways to help you feel better during recovery.