What Causes Fatigue in People with CLL? 

Fatigue is a state of persistent tiredness or weakness, which can be physical, mental, or a combination of both.

Causes of CLL-related fatigue include: 

1. Impact on the immune system: CLL therapies can cause cytokine release syndrome (CRS) and inflammation, contributing to fatigue. Your doctor can prescribe medications to manage these conditions.
2. Decreased red blood cells (anemia): CLL treatments can lower red blood cell counts, leading to anemia and fatigue. If your count is low, a blood transfusion might be suggested.
3. Mitochondrial dysfunction: Some therapies may impair mitochondrial function, reducing cellular energy production and causing fatigue.
4. Treatment-related stress: Managing a chronic illness can cause physical and emotional stress, which often leads to fatigue. Discuss mental health resources with your doctor to help manage stress. 

How is CLL-Related Fatigue Managed?

Fatigue in CLL can be managed through several strategies:

1. Medical management: Address anemia with transfusions or medications, manage cytokine release syndrome (CRS) and inflammation with anti-inflammatory drugs, and support overall health to mitigate mitochondrial dysfunction.
2. Treatment adjustments: Your doctor may adjust your CLL therapy if fatigue is severe.
3. Supportive care: Maintain a balanced diet, engage in gentle exercise, and ensure adequate rest and sleep.
4. Mental health support: Seek counseling or join support groups to manage emotional stress.
5. Lifestyle adjustments: Balance activity and rest. Use stress management techniques to conserve energy.

These approaches help address the various causes of fatigue and support overall well-being.

Click here to watch a webinar where a physical therapist shares some tips on how to manage CLL-related fatigue.