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chevron_left Understanding CLL Treatments: Fixed and Continuous-Duration Therapy Guide

How Effective are Venetoclax + Rituximab?

Last updated on: 11/7/2024

Venetoclax + Rituximab Response as Second Line 

If you are taking VenR as your second line of therapy, listed below is how likely, on average, the treatment combination will be effective for you. 

Response Type Percentage of Patients
CLL patients who achieve undetectable minimal residual disease (uMRD) in a blood sample taken three months after completing the two-year treatment  54%
CLL patients who achieve complete remission (a full reduction of CLL signs/symptoms) after treatment  8%
CLL patients who achieve partial remission (a partial reduction of CLL signs/symptoms) after treatment.  82%

 

How Long Will I Remain in Remission with Venetoclax + Rituximab? (Progression-Free Survival)

On average, this is how long venetoclax + rituximab will keep CLL in remission based on CLL type (the treatment period ends after 2 years).

CLL Genetic Status Years in Remission
All patient group average 4.5
No del(17p)/TP53 mutation 4.7
With del(17p)/TP53 mutation 3.1
Mutated IGHV *5
Unmutated IGHV 4.4

*At the 5-year check-in since the start of treatment, 72.7% of mutated IGHV patients continued to remain in remission.

Side Effect Profile of Venetoclax + Rituximab

The percentage of CLL patients who experience mild-moderate versions of common side effects from VenR is shown below.

Side Effect Percentage of Patients Affected
Neutropenia 65%
Diarrhea 40%
Upper respiratory tract infection 39%
Fatigue 22%
Nausea 21%

 

For more information on these side effects, you can visit the Side Effects Management section of this guide.

For more information on the side effects of VenR, visit the Venclexta Medication Guide.

Financial Resources for Venetoclax + Rituximab

Click here to locate financial resources for venetoclax. For additional resources, click here to visit the financial support section of the guide.