HealthTree Logo
search more_vert
App Logo
person Sign In / Create Account
ASCO 2020: Genetics Predict Smoldering Myeloma Progression
Posted: Jun 11, 2020
ASCO 2020: Genetics Predict Smoldering Myeloma Progression image

A key study shared at the recent ASCO meeting showed that certain genetic features found in myeloma patients could help assess the risk of developing active myeloma. Smoldering myeloma is ia precursor condition that doesn't always progress to active myeloma, so researchers are intent to learn who may benefit from early treatment while others can "watch and wait."  

The Dana Farber Cancer Institute researchers used next-generation sequencing to study 214 patients with smoldering myeloma. They performed whole-exome sequencing on 166 tumors, including 5 with serial samples, and deep targeted sequencing on 48 tumors.

Interstingly, most patients had already acquired most of the genetic mutations needed for myeloma progression, even at the smoldering stage. They identified three pathways that identified patients with a higher risk of progressing. 

  • KRAS and NRAS mutations (changes in the mitogen-activated protein kinase pathway)
  • Deletion of 17p, TP53 and ATM (changes in the DNA repair pathway)
  • Translocations or copy number variations of MYC 

Their findings were validated by a second smoldering myeloma group that showed that patients with any of the three features had a higher risk of progressing to active myeloma. Additionally, they found that APOBEC mutations were higher in patients who progressed to active myeloma and these patients had more rapid progression to active myeloma.

It's essential that patients at the smoldering myeloma stage use genetic testing to identify these features to help determine if and how they should be treated. 

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of HealthTree Foundation (formerly Myeloma Crowd). 

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Janssen Oncology
Adaptive Biotechnologies
Amgen Oncology
Bristol Myers Squibb

Follow Us

facebook instagram twitter youtube