HealthTree Logo
search more_vert
person Sign In / Create Account
Researchers Find that Aerobic Exercise Can Reverse Aging Effects
Posted: Apr 15, 2020
Researchers Find that Aerobic Exercise Can Reverse Aging Effects image

According to an article recently posted on Inverse, “as people age, they lose muscle mass and the risk of heart disease, dementia, and reduced immune function increases. As the years tick by, it becomes harder for people to bounce back from a workout, injury, or illness.”

What can be done to slow down or reverse these aging effects?

For years researchers have promoted exercise for “promoting health span and giving people extra disease-free years“ and ultimately “slowing down the degenerative process.” However, according to new research, experts have found that consistent aerobic exercise may not only slow down the effects of aging, but ultimately REVERSE the effects. How is this possible?


A group of scientists put together a study focused on if “aerobic exercise can cause old cells to behave more like – and gain the characteristics of – young cells.” The results were incredible: 

The Test

“To get there, the scientists rounded up young and old mice and gave them access to a running wheel for three weeks. Then, with a battery of tests, they analyzed how the mouse’s muscle stem cells and muscle tissue responded [after the exercise]. They compared the mouse runners to a group of non-exercising mice who were given a locked wheel and no opportunity to run. Within a single week, both young and old mice with the running wheels established a routine, running about 10 and 4.9 kilometers per night, respectively. The human equivalent to the mice running wheel regime would likely be regular, aerobic exercise— swimming, running, cycling, Rando says. Not strength training or weight lifting.

After three weeks of voluntary wheel running, the mice were moved to cages without any wheels. Then, the researchers injured certain muscles and analyzed how the mice rebuilt the injured tissue. They also transplanted muscle stem cells from old mice into other injured mice and saw how well the cells functioned. Compared with young donor muscle stem cells, old donor muscle stem cells formed smaller and fewer fibers in the injured mice. But old muscle stem cells from exercising mice performed like young muscle stem cells, forming more fibers than non-exercising old muscle stem cells.”


Overall, the study concluded that these older mice who exercised experiences “improved muscles stem cell function and accelerated muscles tissue repair.” This aerobic exercise had a type of rejuvenating effect on old cells. Inverse related it to the “Benjamin Button-effect.”

Neurology researcher, Thomas Rando, explains that this discovery is “very different” because “this is like taking, in a sense, a person who has already aged and acquired these diseases, and then reversed that process.”

Another interesting thing to note was that all of these “rejuvenating” benefits disappeared after ONE WEEK of the mice not exercising, implying that sustained exercise is the key to this anti-aging effect.   


After the study, scientists discovered that this “exercise effect on muscle stem cells and tissue repair come down to a tiny protein called cyclin D1.” Aerobic exercise has a way of “restoring these cyclin D1 levels in dormant stem cells back to youthful levels… effectively accelerating muscle stem cell regeneration.”

Inverse explained that “if the research translates to humans, it means jogging, swimming, cycling, and other aerobic activities can help older people recover as quickly and efficiently as their younger selves. In the far future, these results could inform the creation of a drug that de-ages muscle stem cells.

More research in humans is needed, but it comes down to the idea that aerobic exercise has extreme benefits for one’s health. To read more from Inverse, click here.


Interested in participating in activities influenced by aerobic exercise? Join one of our Muscles for Myeloma fitness challenges: 

MoveSpring Fitness Challenge

This free challenge will focus on STEPS and staying active through COVID-19. We use an app called MoveSpring which allows you to record your steps either through a device (FitBit, Apple Watch, etc.) or you can manually enter it into the system. Our team (and the myeloma community chat) will encourage you every step of the way with workout videos from our team, walking/running fitness plans, and an overall focus to encourage you to stay healthy (and sane) during such a stress-induced time. Download the app today!


Join the MoveSpring Fitness Challenge!


Muscles for Myeloma Virtual Race

On Saturday, May 30, join us as we unite for the Muscles for Muscles for Myeloma Virtual Race! Each race participant will have a shirt and bib mailed directly to their home (packaged in a safe and sanitized manner). This revised race format provides an increased opportunity to come together as a myeloma community to get active, without the possibility of contracting the virus.


join the Muscles for Myeloma Virtual Race!


The author Allyse Shumway

about the author
Allyse Shumway

MyelomaCrowd Editorial Contributor. Daughter to a parent with cancer.

Get the latest thought leadership on Multiple Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Multiple Myeloma Newsletter" for Multiple Myeloma news, life with Multiple Myeloma stories, Multiple Myeloma clinical trials, Multiple Myeloma 101 articles and events with Multiple Myeloma experts.

Thanks to our HealthTree Community for Multiple Myeloma Sponsors:

Johnson and Johnson
Bristol Myers Squibb

Follow Us

facebook instagram linkedin tiktok youtube