HealthTree Logo
search more_vert
App Logo
close
person Sign In / Create Account
How To Reduce Infections During Myeloma Stem Cell Transplant
Posted: Mar 31, 2018
How To Reduce Infections During Myeloma Stem Cell Transplant image

Supportive care during stem cell transplant typically includes the use of strong antibiotics like ciprofloxacin or levofloxacin. Researchers performed a study reported in Supportive Cancer Care  to see whether the addition to doxycycline to ciprofloxacin would be beneficial for myeloma patients. In the study, researchers reviewed electronic medical records and their stem cell transplant database to analyze rates and types of bacterial infections in myeloma patients who underwent autologous stem cell transplant at Penn State Health-M.S. Hershey Medical Center. In 419 patients, 118 received ciprofloxacin alone and 301 received both ciprofloxacin and doxycycline.

Ciprofloxacin Group

  • Neutropenic fevers - 53%
  • Bacterial episodes - 11%

Ciprofloxacin and Doxycycline Group

  • Neutropenic fevers - 36%
  • Bacterial episodes - 4.7%

Antimicrobial resistance and Clostridium difficile (C-diff) infections were uncommon. Transplant-related mortality was 1% in both groups. The researchers concluded that adding doxycycline to standard uses of Cipro reduced the number of neutropenic fevers and bacterial infections without increasing the rate of serious complications.

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of Myeloma Crowd by HealthTree and the HealthTree Foundation.

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Janssen Oncology
Amgen Oncology
Abbvie
Genentech
GSK
Bristol Myers Squibb

Follow Us

facebook instagram twitter youtube