Clinical Trial: Juno Therapeutics CAR T Cell Therapy for Relapsed or Refractory Myeloma

Juno Therapeutics today opens its Phase 1/2 study to determine the safety and efficacy of JCARH125, a CAR T-cell product that targets B-cell maturation antigen (BCMA), in adult patients s with relapsed or refractory multiple myeloma. The study will include a Phase 1 part to determine the recommended dose of JCARH125, followed by a Phase 2 part to further evaluate the safety and efficacy of JCARH125 at the recommended dose.
Juno Therapeutics and Celgene have announced a partnership on this CAR T product. The study is open at Memorial Sloan Kettering Cancer Center and is anticipated to be open at additional centers in the future.
Participants will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) for the production of JCARH125. During JCARH125 production, participants may receive bridging chemotherapy for disease control. Following successful generation of JCARH125 product, participants will receive a course of lymphodepleting chemotherapy followed by one dose of JCARH125 administered intravenously (IV).
To learn more, click here: Juno CAR T Clinical Trial
Juno Therapeutics today opens its Phase 1/2 study to determine the safety and efficacy of JCARH125, a CAR T-cell product that targets B-cell maturation antigen (BCMA), in adult patients s with relapsed or refractory multiple myeloma. The study will include a Phase 1 part to determine the recommended dose of JCARH125, followed by a Phase 2 part to further evaluate the safety and efficacy of JCARH125 at the recommended dose.
Juno Therapeutics and Celgene have announced a partnership on this CAR T product. The study is open at Memorial Sloan Kettering Cancer Center and is anticipated to be open at additional centers in the future.
Participants will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) for the production of JCARH125. During JCARH125 production, participants may receive bridging chemotherapy for disease control. Following successful generation of JCARH125 product, participants will receive a course of lymphodepleting chemotherapy followed by one dose of JCARH125 administered intravenously (IV).
To learn more, click here: Juno CAR T Clinical Trial

about the author
Jennifer Ahlstrom
Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can contribute to cures by joining HealthTree Cure Hub and joining clinical research. Founder and CEO of HealthTree Foundation.
More on Navigating Your Health
Trending Articles





Get the Latest Multiple Myeloma Updates, Delivered to You.
By subscribing to the HealthTree newsletter, you'll receive the latest research, treatment updates, and expert insights to help you navigate your health.