But with myeloma therapy typically given in combinations, what does a "line" include? It was confusing even for myeloma experts like Vincent Rajkumar, MD (Mayo Clinic), Paul Richardson, MD (Dana Farber Cancer Institute) and Jesus San Miguel, MD, PhD (University of Navarra, Spain) better to define the criteria in an article published by the American Society of Hematology.
One line of therapy consists of any of the following:
Seems like a lot of therapy for one line, right? But it's still considered one line of therapy.
A new line of therapy would be considered:
Examples of "New"Lines of Therapy:
Lenalidomide plus low-dose dexamethasone (RD) as initial therapy, and due to inadequate response, bortezomib is added (RVD): This is counted as 2 lines.
Toxicity with lenalidomide plus dex as pre-transplant induction, and therefore treatment is switched to bortezomib, cyclophosphamide, and dexamethasone (VCD): RD is counted as 1 line; VCD (and subsequent planned SCT) is line 2.
Post-transplant observation without maintenance, and then, due to paraprotein rise 6 months later, lenalidomide is started, which is not planned maintenance; hence, lenalidomide will be considered as a new line.
If you have other questions on what may qualify you for specific clinical trials, ask your doctor or nurse about your prior lines of therapy. Staying informed is a smart way to get the most out of your treatment.
By securely connecting your electronic health records, HealthTree Cure Hub allows you to discover treatment options, find a specialist, keep track of your disease, and so much more! Sign up for a free patient account today to get started.
But with myeloma therapy typically given in combinations, what does a "line" include? It was confusing even for myeloma experts like Vincent Rajkumar, MD (Mayo Clinic), Paul Richardson, MD (Dana Farber Cancer Institute) and Jesus San Miguel, MD, PhD (University of Navarra, Spain) better to define the criteria in an article published by the American Society of Hematology.
One line of therapy consists of any of the following:
Seems like a lot of therapy for one line, right? But it's still considered one line of therapy.
A new line of therapy would be considered:
Examples of "New"Lines of Therapy:
Lenalidomide plus low-dose dexamethasone (RD) as initial therapy, and due to inadequate response, bortezomib is added (RVD): This is counted as 2 lines.
Toxicity with lenalidomide plus dex as pre-transplant induction, and therefore treatment is switched to bortezomib, cyclophosphamide, and dexamethasone (VCD): RD is counted as 1 line; VCD (and subsequent planned SCT) is line 2.
Post-transplant observation without maintenance, and then, due to paraprotein rise 6 months later, lenalidomide is started, which is not planned maintenance; hence, lenalidomide will be considered as a new line.
If you have other questions on what may qualify you for specific clinical trials, ask your doctor or nurse about your prior lines of therapy. Staying informed is a smart way to get the most out of your treatment.
By securely connecting your electronic health records, HealthTree Cure Hub allows you to discover treatment options, find a specialist, keep track of your disease, and so much more! Sign up for a free patient account today to get started.
about the author
Jennifer Ahlstrom
Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can contribute to cures by joining HealthTree Cure Hub and joining clinical research. Founder and CEO of HealthTree Foundation.
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