Can Diet or Supplements Help Slow Myeloma Progression?

Can a plant-based diet or specific supplements (omega-3, curcumin, or probiotics) change the gut microbiome in a way that helps prevent or slow myeloma progression?

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STUDY IMPACT

Your large intestine contains a community of bacteria called your gut microbiome, which promotes your health in various ways. One of your gut bacteria’s important substances is butyrate, a short chain fatty acid that is produced by some types of gut bacteria when they break down or digest fiber. Butyrate is being studied for its potential effect against both cancer and inflammation.

Researchers have seen that a plant-based diet may increase butyrate levels. A plant-based diet includes foods that are mainly found in plants (for example, fruits, vegetables, nuts, beans, and whole grains). Researchers have also seen that omega-3, curcumin, and probiotic supplements may increase butyrate levels when taken alone. This study is designed to evaluate how butyrate levels change in participants’ stool after they are on a plant-based diet or supplements for at least 2 weeks. Information from this study will help understand the usefulness of plant-based diets or dietary supplements (omega-3, curcumin, or probiotics) in preventing progression to multiple myeloma in people with monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM).

WHO CAN JOIN

People with MGUS or SMM who meet study eligibility criteria and are open to making a temporary change to their diet or supplementation intake.

WHAT'S INVOLVED:

• 2 weeks of diet or supplements
• No travel, no cost: everything is provided, including meals or supplements
• You’ll log your meals, send a few stool samples (with prepaid kits), and answer short weekly check-ins

The study has four groups, and participants could be randomized into any of them: a whole-food plant-based diet, omega-3, curcumin, or probiotics.

 Join the Study Today

If you have any questions, please contact Support, at (800) 709-1113 or send us an email at support@healthtree.org

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