[logo] HealthTree Foundation
search person

For normal-risk, newly diagnosed myeloma patients, which triple drug combination is more effective?

Posted: Dec 11, 2013
For normal-risk, newly diagnosed myeloma patients, which triple drug combination is more effective? image

This is a randomized Phase III trial (half of the patients receive one combination and half receive the other combination) to determine which combination is a better starting approach for a newly diagnosed myeloma patient with active disease. Is VRD (bortezomib, lenalidomide and dexamethasone) better or is CRD (carfilzomib, lenalidomide and dexamethasone) better? Each group receives one of the two combinations and then are both given lenalidomide maintenance therapy indefinitely. This is called the ENDURANCE trial by investigators and is looking to recruit 756 patients that are not considered high-risk. This trial assumes that stem cell transplant will NOT be used as an up-front therapy. Learn more >

This is a randomized Phase III trial (half of the patients receive one combination and half receive the other combination) to determine which combination is a better starting approach for a newly diagnosed myeloma patient with active disease. Is VRD (bortezomib, lenalidomide and dexamethasone) better or is CRD (carfilzomib, lenalidomide and dexamethasone) better? Each group receives one of the two combinations and then are both given lenalidomide maintenance therapy indefinitely. This is called the ENDURANCE trial by investigators and is looking to recruit 756 patients that are not considered high-risk. This trial assumes that stem cell transplant will NOT be used as an up-front therapy. Learn more >

The author Jennifer Ahlstrom

about the author
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can contribute to cures by joining HealthTree Cure Hub and joining clinical research. Founder and CEO of HealthTree Foundation. 

Thanks to our sponsors:
Sanofi logo
Adaptive logo
Pfizer logo
GSK logo
newsletter icon

Get the Latest Multiple Myeloma Updates, Delivered to You.

By subscribing to the HealthTree newsletter, you'll receive the latest research, treatment updates, and expert insights to help you navigate your health.