A unique four-drug combination including isatuximab, pomalidomide, elotuzumab, and dexamethasone in the IMPEDE study is being tested for relapsed/refractory myeloma.
The study uses two monoclonal antibodies that go after two different targes (isatuximab for CD38 and elotuzumab for SLAMF7) with an immunomodulator and steroid. The study seeks to prove that adding isauximab will be safe and improve responses in relapsed myeloma.
The main study consists of three phases:
This will be done in two different parts:
The study will evaluate response to treatment according to the International Myeloma Working Group’s criteria:
For years 1-3, the number of patients in each response category will be noted at the end of each year.
Patients can join if they have already received 2 prior myeloma therapies that include lenalidomide with a proteasome inhibitor and their myeloma is progressing on their current myeloma treatment.
For more information about the inclusion/exclusion criteria, click here.
The study is open at Froedtert Hospital & the Medical College of Wisconsin in Milwaukee.
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about the author
Andrea Robles is an International Medical Graduate, part of Healthtree’s patient navigator staff. She is committed to patient’s global wellness and finding a cure through research. She’s also a wife and mom of 3.