High risk smoldering myeloma patients are those who are most likely to progress to active myeloma within a two year period. This research study is evaluating a new checkpoint inhibitor called "nivolumab" as a possible treatment for smoldering multiple myeloma in order to prevent or postpone development of active multiple myeloma. Patients with smoldering multiple myeloma do not have symptoms but are at risk for progressing to active multiple myeloma. Checkpoint inhibitors take the "brakes" off the immune system that have been put on by myeloma cells or other gene errors. 

The study includes nivolumab, lenalidomide and dexamethasone and is open at two locations.

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 Nivolumab, Revlimid and Dex Clinical Trial

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