Could adding a third drug to myeloma combination therapy improve outcomes and actually decrease side effects? Yes! A recent study showed that adding daratumumab to lenalidomide and dex not only provided patients with better outcomes, it significantly reduced pain.
Data from the Phase 3 MAIA trial presented at this year's ASH annual meeting, was presented by Aurore Perrot, MD, PhD from the University of Toulouse. The study compared triplet therapy D-Rd ( Daratumumab, Lenalidomide, and Dexamethasone) Vs. Rd (Lenalidomide and Dexamethasone).
Dr. Perrot concluded that all frail patients treated with triplet therapy D-Rd had better physical functioning and significantly reduced pain symptoms (As seen in the following chart). They also had favorable changes in social functioning and decreased symptoms like nausea and vomiting.
The treatments were effective against their myeloma and substantially benefited their overall health.
It's good to know that adding another therapy like a monoclonal antibody will provide patients with better outcomes and improve quality of life at the same time.
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about the author
Marilú Nájera Flores
Marilú is an International Medical Graduate who joined HealthTree as part of the Patient Experience team. She assists patients at different stages of the disease, MGUS and Smoldering myeloma, and those facing active myeloma, helping them comprehend and effectively track their test results and overall health history. She is a Disney fan, travel enthusiast, passionate novel reader, cheerful, friendly person, and a good listener who enjoys spending quality time with her family and friends.
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