I believe this might be the best kept secret at ASH 2018.
As can be seen from the following graph, Median Overall survival had not been reached at 24 months.
![](https://storage.googleapis.com/crowdnews-media-library/2018/12/804D805B-C2C4-4C6A-B590-7CFDF6FAB0F7-300x220.jpeg)
The results of this trial are listed below with the end points being reached, at a overall response rate ORR of 87%, and Median progression free survival PFS of 18 months.
Why might this be the best kept secret? Well, if I look at overall response rates on other myeloma relapsed/refractory studies, 87% is a class leader.
I am aware it is frowned on to look at data between studies, however many people do (and I will), but only as a means to identify trends. I conducted a search of salvage therapies for relapsed/refractory myeloma and the following is a sample of the overall response rate in a small sample of them. But what can be seen is the PKd regimen with a ORR of 87% is directionally exceptional! Here are some of the other studies:
- Phase I Trial of Anti-CS1 Monoclonal Antibody Elotuzumab in Combination With Bortezomib in the Treatment of Relapsed/Refractory Multiple Myeloma - ORR of 48%
- Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study - ORR of 33%
- Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial - ORR of 29.2%
- Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase I/II open-label, dose escalation study - ORR of 52%
- PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma - ORR of 34%
Upcoming immunotherapies such as CAR T, bITEs and others are seeing response rates in the 80-90% but for these classes of drugs, this study is showing exceptional results.
I believe this might be the best kept secret at ASH 2018.
As can be seen from the following graph, Median Overall survival had not been reached at 24 months.
![](https://storage.googleapis.com/crowdnews-media-library/2018/12/804D805B-C2C4-4C6A-B590-7CFDF6FAB0F7-300x220.jpeg)
The results of this trial are listed below with the end points being reached, at a overall response rate ORR of 87%, and Median progression free survival PFS of 18 months.
Why might this be the best kept secret? Well, if I look at overall response rates on other myeloma relapsed/refractory studies, 87% is a class leader.
I am aware it is frowned on to look at data between studies, however many people do (and I will), but only as a means to identify trends. I conducted a search of salvage therapies for relapsed/refractory myeloma and the following is a sample of the overall response rate in a small sample of them. But what can be seen is the PKd regimen with a ORR of 87% is directionally exceptional! Here are some of the other studies:
- Phase I Trial of Anti-CS1 Monoclonal Antibody Elotuzumab in Combination With Bortezomib in the Treatment of Relapsed/Refractory Multiple Myeloma - ORR of 48%
- Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study - ORR of 33%
- Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial - ORR of 29.2%
- Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase I/II open-label, dose escalation study - ORR of 52%
- PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma - ORR of 34%
Upcoming immunotherapies such as CAR T, bITEs and others are seeing response rates in the 80-90% but for these classes of drugs, this study is showing exceptional results.