Lenalidomide maintenance was then given in all arms.
The study included a total of 1503 patients under the age of 65 with 618 of those patients being split into a VMP (203 patients), single transplant (208 patients) or tandem transplant arm (207 patients). The study objective looked at progression-free survival. The study included a large number of high risk patients (as defined by t(4;14), t(14;16), deletion 17p, deletion 1p or gain of 1q status) in the single or tandem transplant arms. The median follow-up was 38 months. The three-year estimate of progression free survival was 73% for the tandem transplant group vs. 64% for the single transplant group, which represented a 30% reduced risk. (Figure 1a) Overall survival was prolonged with the tandem transplant (89%) vs. the single transplant (82%). (Figure 1c) For high risk patients, the progression free survival was also extended, helping them receive similar outcomes as standard risk patients. (Figure 1b) Europe as a whole does not have access to some treatments and combination therapies typically used in the United States. With fewer drugs approved, they were able to utilize tandem transplant as an effective tool to prolong progression free and overall survival, especially those with high risk disease. The addition of bortezomib in the tandem transplant arm also assisted high risk patients (especially those with del17p) in obtaining better outcomes.