Two panels of patients, one who had received bispecific antibody therapy and one who had not, created a list of questions to ask your doctor about bispecific antibody therapy. Whether you are a current candidate for this therapy or would like to know more about the treatment for future use, these questions can serve as a great conversation starter. 

Qualifying for bispecific antibody therapy 

• Do I qualify for bispecific antibody therapy? Why/why not?
• How many lines of therapy do I need to qualify for bispecific therapy? 
• Are there any screening tests that need to be taken before bispecific antibody therapy? If so, which ones? 
• Is there anything about my specific myeloma case or health profile that would preclude me from getting bispecific therapy?  

Physician insights on bispecific therapy

• How familiar are you with bispecific antibody therapy? Have you done any personal research in this field? 
• What physician (from a different academic center) would you recommend for a second opinion on this subject? 
• Do you have any patients currently on bispecific therapy? Which therapies? In general, how have they responded? 
• Are you more likely to go by the book or adapt as necessary when real-world data presents new ideas for bispecific antibody therapy? 

Choosing a bispecific antibody 

• How do I decide which of the bispecific therapies is best for me? 
• What are the key differences between the FDA-approved therapies? 
• What bispecific have you seen the most success with among patients with my similar genetic profile? 

Bispecific antibody clinical trial questions 

• Do you know of an open clinical trial of bispecific antibodies at this facility? If not, where is one near me?
• Would it be appropriate for me to consider a bispecific in a clinical trial instead of one that is FDA-approved? 

Sequencing bispecific antibodies

• If I have received a bispecific antibody therapy already, can you prescribe me a different one and have it work effectively? 
• Because I have had BCMA-targeting therapy previously, will a BCMA-targeting bispecific antibody work for me? 
• Should I have CAR T-cell therapy before considering bispecifics? 

Side effects of bispecific antibodies

• How common/serious are side effects like ICANS and CRS? When can these side effects occur? 
• How do I manage these side effects? What warning signs should I be monitoring? 
• What medications do you give to prevent infections? What infections am I at risk for contracting?
• What are the warning signs of infection? When should I contact you? 
• What can I do to prevent infection? 
• How long am I at risk of these side effects? 

Bispecific antibody therapy responses

• How deep of a response do you think that I can get from this drug? Would you like to set a goal in terms of depth of response? 
• How long could I expect to get a response from this drug?

Resources and access to bispecific antibody therapy treatment

• How much will these therapies cost me?
• Does this facility provide any financial assistance?
• Can you connect me with a social worker?