Dr. William Matsui, MD
Johns Hopkins University
Interview Date: February 16, 2018
Allogeneic (or donor) stem cell transplant has become much safer over the last 20 years. For those who have high risk myeloma features, it should be considered as a potential option. Dr. William Matsui, MD of Johns Hopkins University (and soon to be leading a myeloma practice in Austin, TX) shares his experience with allo transplant for all patients, regardless of their age. He notes that a younger donor may be better than a closer match, which makes it less difficult to find family donors. The paradigm has shifted for this treatment option that could be potentially curative for patients. His current study is to learn to how enhance and extend remissions for allo patients using an antibody called MEDI-551. Dr. Matsui also describes potential study for early or precursor B-cell targets which could help eliminate all myeloma and precursor myeloma cells.
Thanks to our episode sponsor, Takeda Oncology
William Matsui, MD, is Deputy Director of the LIVESTRONG Cancer Institutes, Professor in the Department Oncology and Director of Hematological Malignancies Program at the Dell Medical School at the University of Texas at Austin. He specializes in caring for patients with cancers that involve the blood and bone marrow as well as bone marrow transplantation. He came to Austin from the Johns Hopkins University School of Medicine, where he was a professor of oncology and served as the director of the Multiple Myeloma Program and the co-director of the Division of Hematologic Malignancies. Dr. Matsui has carried out laboratory-based translational research throughout his career and focused on studying cancer stem cells, tumor cells with enhanced growth potential and their role in clinical oncology. His laboratory first identified cancer stem cells in the plasma cell malignancy multiple myeloma in 2003 and subsequently in other cancers including lymphomas, leukemias and pancreas cancer. His laboratory has also demonstrated that several pathways regulating normal stem cells, including those involved in embryonic development, are abnormally activated in cancer stem cells. Dr. Matsui completed his residency training in internal medicine at the University of Washington in Seattle and his clinical training in medical oncology at Johns Hopkins. He earned his medical degree from the University of California at San Francisco.
Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of the HealthTree Foundation.
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