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Showing 396 trials matching your filters.

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carci...

Background: Aldesleukin is used to treat metastatic or advanced melanoma and renal cell carcinoma. Pembrolizumab is used to treat many cancers including melanoma. Researchers want to see if these drugs can be used together to produce better results ...

DRUG: Pembrolizumab

DRUG: Aldesleukin

A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying...

Belantamab mafodotin is an antibody-drug conjugate (ADC) containing humanized anti- B-cell maturation antigen (BCMA) monoclonal antibody (mAb). Renal impairment is a major complication of multiple myeloma (MM) and the majority of MM participants is e...

DRUG: Belantamab mafodotin

A Study of Combination Spartalizumab and Canakinumab in Patients With Localized Clear Cell Renal Cel...

Primary Objective: * To confirm the safety and feasibility of canakinumab and spartalizumab (PDR-001) administered using a standard dose / schedule in the neo-adjuvant setting in renal cell carcinoma Secondary Objectives: * To assess the immune re...

DRUG: Spartalizumab

DRUG: Canakinumab

A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumo...

This study aims to evaluate the safety, and early signals of anti-tumor activity of PF-07820435 when administered alone (Part 1A) or in combination with sasanlimab (Part 1B; Part 2) in patients with selected advanced or metastatic solid tumors. Part ...

DRUG: PF-07820435

BIOLOGICAL: Sasanlimab

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Rem...

This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer that has spread to othe...

PROCEDURE: Cytoreductive Nephrectomy

DRUG: Active Comparator

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Par...

The purpose of this study is to evaluate the efficacy and safety of belzutifan monotherapy and belzutifan plus palbociclib combination therapy in participants with advanced clear-cell renal cell carcinoma (ccRCC) who experienced disease progression o...

DRUG: Belzutifan

DRUG: Palbociclib

Telavancin Blood and Cerebrospinal Fluid Concentrations in Patients With Subarachnoid Hemorrhage

The proposed study aims to evaluate the CNS penetration of telavancin in a critically ill population using cerebrospinal fluid (CSF) drawn from external ventricular drains (EVDs) in patients who have had spontaneous subarachnoid hemorrhage (SAH). Pat...

DRUG: Telavancin Injection

Abdominal Wall Transplant

The purpose of this protocol is to determine the safety and efficacy of abdominal wall transplantation as a treatment for the reconstruction of abdominal wall defects. Abdominal wall transplantation may be performed alone or in combination with anoth...

PROCEDURE: Abdominal Wall Transplant with another solid organ transplant

PROCEDURE: Abdominal Wall Transplant alone

ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficienc...

The purpose of this study (Study INZ701-304 \[ADAPT\]) is to assess the long-term safety of INZ-701 in patients with ENPP1 Deficiency or ABCC6 Deficiency who have received INZ-701 in an existing clinical study and choose to continue dosing for the po...

DRUG: INZ-701

A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastati...

This study is about TAK-500, given either alone or with pembrolizumab, in adults with select locally advanced or metastatic solid tumors. The aims of the study are: * to assess the safety profile of TAK-500 when given alone and when given with pemb...

DRUG: TAK-500

DRUG: Pembrolizumab

A Study to Find Out if ASP5354 Can Clearly Help Show the Ureter During Surgery in People With or Wit...

The ureter is the tube that carries urine from the kidneys to the bladder. It is difficult for surgeons to see the ureter during abdominal surgery. This could lead to injuring the ureter which, although rare, could be serious. This study is about a ...

DRUG: pudexacianinium chloride

A Study of Rapcabtagene Autoleucel in Systemic Lupus Erythematosus (SLE) Patients With Active, Refra...

The purpose of this study is to evaluate the efficacy and safety of rapcabtagene autoleucel (administered once following lymphodepletion) versus Standard of Care (SOC) in patients with systemic lupus erythematosus (SLE) with active, refractory lupus ...

BIOLOGICAL: rapcabtagene autoleucel Regimen 1

BIOLOGICAL: rapcabtagene autoleucel Regimen 2

OTHER: Standard of Care

Long-term Efficacy, Safety and Tolerability of Iptacopan in C3G or IC-MPGN

This is an open-label extension study to evaluate the long-term efficacy, safety and tolerability of iptacopan in subjects with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis

DRUG: LNP023

Study of XL092 in Combination With Immuno-Oncology Agents in Subjects With Solid Tumors

This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, PK, preliminary antitumor activity, and effect of biomarkers of XL092 administered alone, and in combination with nivolumab (...

DRUG: XL092

DRUG: Nivolumab

DRUG: Ipilimumab

DRUG: Nivolumab

DRUG: Nivolumab + Relatlimab

A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma Th...

The purpose of this study is to find out whether the combination of cabozantinib, nivolumab, and radiation therapy is a safe and effective treatment that causes few or mild side effects in people with renal cell cancer that has spread to the brain. T...

DRUG: Cabozantinib

DEVICE: Nivolumab

RADIATION: Stereotactic Radiosurgery (SRS)

Cerebrovascular Dysregulation in Chronic Kidney Disease

The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).

BEHAVIORAL: Exercise

BEHAVIORAL: Stretching

SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)

The goal of this clinical trial is to test the Break Wave™ system in patients with upper urinary tract stones. The main question it aims to answer is whether the device is safe and effective in fragmenting (breaking) stones. Participants will a) und...

DEVICE: Break Wave extracorporeal lithotripsy

A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

The purpose of this study is to find out whether selinexor is an effective treatment for people who have a relapsed/refractory Wilms tumor, rhabdoid tumor, MPNST, or another solid tumor that makes a higher than normal amount of XPO1 or has genetic ch...

DRUG: Selinexor

A Study of CNTY-101 in Participants With Refractory B Cell-mediated Autoimmune Diseases (CALiPSO-1)

CALiPSO-1 is a Phase 1, multi-centre, dose-finding study to evaluate the safety and efficacy of CNTY-101 in participants with refractory B cell-mediated autoimmune diseases including those with moderate to severe systemic lupus erythematosus (SLE), w...

BIOLOGICAL: CNTY-101

BIOLOGICAL: IL-2

DRUG: Lymphodepleting Chemotherapy

A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors

This is a pilot study of LTLD with MR-HIFU hyperthermia followed by ablation in subjects with refractory/relapsed solid tumors.

DEVICE: Magnetic Resonance-Guided High Intensity Focused Ultrasound

DRUG: Lyso-thermosensitive Liposomal Doxorubicin

Lenvatinib With Everolimus Versus Cabozantinib for Second-Line or Third-Line Treatment of Metastatic...

This phase II trial compares the effects of lenvatinib given in combination with everolimus to the effects of cabozantinib given alone in treating patients with renal cell cancer (RCC) that has spread to other parts of the body (metastatic) and that ...

DRUG: Cabozantinib

DRUG: Everolimus

DRUG: Lenvatinib

OTHER: Questionnaire Administration

Trial Of Stereotactic Body Radiation Therapy (SBRT) for Oligoprogression on Immune Checkpoint Inhibi...

This Phase II trial will evaluate progression-free survival after Stereotactic Body Radiation Therapy to oligoprogressive (1-5) lesions in metastatic renal cell carcinoma patients on any immune checkpoint inhibitor-containing regimen with last dose o...

RADIATION: Stereotactic Body Radiation Therapy

A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysi...

The CSP-2002 study will evaluate the safety and effectiveness of the InnAVasc arteriovenous graft (AVG) when implanted in and used for hemodialysis in participants suffering from end-stage renal failure (ESRD). The InnAVasc AVG is implanted and used ...

DEVICE: InnAVasc arteriovenous graft surgical implant

DIALYSIS-TIR Study

This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide to people taking "dummy" medicine. The treatment pa...

DRUG: Semaglutide

DRUG: Placebo

Uric Acid Lowering Trial in Youth Onset T2D

Adolescents and young adults with youth-onset type 2 diabetes (T2D) are disproportionally impacted by hyperuricemia compared to non-diabetic peers and youth with type 1 diabetes (T1D). In fact, 50% of males with youth-onset T2D have serum uric acid (...

DRUG: Pegloticase 8 MG/ML [Krystexxa]

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

The primary purpose of this study is to assess the safety and tolerability of AB598 when taken alone, and in combination with zimberelimab and standard chemotherapy in participants with advanced malignancies.

DRUG: AB598

DRUG: Zimberelimab

DRUG: Carboplatin

DRUG: Pemetrexed

DRUG: Fluorouracil

DRUG: Leucovorin

DRUG: Oxaliplatin

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

This is a phase I/II study that will evaluate the safety and toxicity of this combinatorial approach. Eligible patients \>18 years of age with histologically proven metastatic NSCLC, melanoma, RCC, or HNSCC who have failed PD-1 / PD-L1 checkpoint blo...

DRUG: IL-2

DRUG: Pembrolizumab

RADIATION: Radiotherapy

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

This is a Phase 1b, open-label, multicenter, safety, tolerability and efficacy study of HC-7366 in combination with belzutifan (WELIREG™). This is a multipart study that consists of a HC-7366 monotherapy cohort, a combination dose escalation, and a c...

DRUG: HC-7366

DRUG: Belzutifan

An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute...

This is a single center randomized trial that seeks to determine if the use of an automated real-time electronic medical record Acute Kidney Injury (AKI) risk score can improve patient outcomes through the use of an early standardized nephrology focu...

OTHER: Early Nephrology Consult (ENC)

OTHER: Standard of Care (SOC)

Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants With C...

This Phase 1b study of DISC-0974 will assess the safety, tolerability, pharmacokinetics (PK) and Pharmacodynamics (PD) of DISC-0974 in adult participants with Non-Dialysis Dependent Chronic Kidney Disease and Anemia.

DRUG: DISC-0974

DRUG: Placebo

Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off

The purpose of this study is to compare Moses 2.0 pulse modulation technology and the standard high powered Holmium Laser lithotripsy and how it will affect time in the operating room, time using the laser, laser energy, and stone free rates. Curren...

PROCEDURE: Dusting without Moses 2.0 Modulation

PROCEDURE: Dusting with Moses 2.0 Modulation

OTHER: Moses 2.0 Modulation

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With A...

The purpose of this study is to test the safety and tolerability of HFB200301 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study. During the escalation part, groups of participa...

DRUG: HFB200301

DRUG: Tislelizumab

Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or ...

Background: Kidney cancer is the 12th leading cause of cancer-related death in the United States. Some kidney tumors do not respond well to current treatments. Better treatments are needed. Objective: To test a pair of drugs (sasanlimab and palboc...

DRUG: Sasanlimab

DRUG: Palbocicilib

Transcutaneous Auricular Vagus Nerve Stimulation Device in CKD Population

The purpose of this pilot interventional study is to collect preliminary data on the application of a transcutaneous auricular vagal nerve stimulation (taVNS) device in patients with chronic kidney disease (CKD). This data will enhance understanding ...

DEVICE: Transcutaneous electrical nerve stimulation unit (TENS)

Janus Kinase-STAT Inhibition to Reduce APOL1 Associated Kidney Disease

The purpose of this study is to determine if the drug, baricitinib, is safe and effective in reducing high levels of albumin in the urine (albuminuria) in African American/Blacks with APOL1- associated focal segmental glomerulosclerosis (FSGS) and no...

DRUG: Baricitinib

DRUG: Placebo

Acute Equol Supplementation and Vascular Function in Women With and Without CKD

The risk of cardiovascular disease (CVD) is significantly elevated in patients with chronic kidney disease (CKD). Notably, women with CKD commonly experience menstrual disturbances induced by CKD, which may contribute to impaired vascular function an...

DRUG: S-equol

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

This is a Prospective, controlled, single-blind, randomized (2:1, Intervention:Control) clinical trial. The purpose of the study is to determine the role of adjunctive renal sympathetic denervation in the prevention of Atrial Fibrillation (AF) recurr...

DEVICE: Renal Denervation

DEVICE: Catheter Ablation

A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics and Safety of VIR-2218

The rationale of this study is to evaluate the impact of renal function on the PK, safety, and tolerability of VIR-2218 in participants with normal renal function and participants with varying degrees of renal dysfunction who are otherwise medically ...

DRUG: VIR-2218

Ureteral Stent Placement After Ureteroscopy for Renal Stones: A Randomized Controlled Trial

The rationale for this study is to determine if there is a difference in complications among patients undergoing ureteroscopy for renal stones who receive a stent compared to not receiving a stent postoperatively.

PROCEDURE: Ureteroscopy

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects ...

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

BIOLOGICAL: CABA-201

Drug Screening Using Novel IMD in Renal Cell Carcinoma

This research is being done to study the safety and feasibility of implanting and retrieving a microdevice that releases microdoses of 19 specific drugs or drug combinations as a possible tool to evaluate the effectiveness of several cancer drugs aga...

COMBINATION_PRODUCT: Implantable Microdevice (IMD)

Sequential Treatment of Cabozantinib or Cabozantinib With Nivolumab for Advanced Renal Cell Carcinom...

The goal of this clinical trial is to learn about the effects of a higher dose of cabozantinib or the effects of cabozantinib-nivolumab combination in patients with advanced renal cell carcinoma who have progressed on or after receiving cabozantinib ...

DRUG: Cabozantinib 80 MG

DRUG: Cabozantinib 40Mg Tab

DRUG: Nivolumab

AB-2100, an Integrated Circuit T (ICT) Cell Therapy in Patients With Recurrent Clear-cell Renal Cell...

This is a multi-center, open-label phase 1/2 trial evaluating the safety and efficacy of AB-2100 cell product. The study may enroll approximately 60 patients in phase 1 and approximately 70 patients in phase 2.

BIOLOGICAL: AB-2100

The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4...

The purpose of this trial is to evaluate the effectiveness and safety of the HistoSonics Edison System for the destruction of kidney tissue by treating primary solid renal tumors.

DEVICE: HistoSonics Edison System

Learning Alerts for Acute Kidney Injury

The primary objective of this study is to determine whether the use of uplift (also known as Conditional Average Treatment Effect - CATE) modeling to empirically identify patients expected to benefit the most from AKI alerting and to target AKI alert...

OTHER: Alert

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment ...

This phase Ib trial evaluates the best dose, potential benefits, and/or side effects of erdafitinib in combination with enfortumab vedotin in treating patients with bladder cancer that has spread from where it first started (primary site) to other pl...

PROCEDURE: Biospecimen Collection

PROCEDURE: Computed Tomography

DRUG: Enfortumab Vedotin

DRUG: Erdafitinib

Pencil Beam Scanning in Patients With Renal Tumors

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

OTHER: Proton beam radiation using pencil beam scanning

Bortezomib, Isatuximab, Cyclophosphamide and Dexamethasone Induction in Transplant-Eligible Multiple...

This is a single-arm, open-label phase II study with a safety lead-in phase.

DRUG: Bortezomib

DRUG: Isatuximab

DRUG: Cyclophosphamide

DRUG: Dexamethasone

The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Sol...

This phase I clinical trial tests the immune effects of fermented wheat germ in patients with advanced solid tumor cancers who are being treated with standard of care checkpoint inhibitors. Fermented wheat germ is a nutritional supplement that some c...

DRUG: Fermented Wheat Germ Extract

Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer

The purpose of this study is to see if the combination of 177Lu-girentuximab and nivolumab is a safe and effective treatment for advanced clear cell renal cell carcinoma/ccRCC that has the CAIX protein.

DRUG: 177Lu-labeled-girentuximab

DRUG: Nivolumab

DIAGNOSTIC_TEST: 89Zr-girentuximab PET/CT

DIAGNOSTIC_TEST: 177Lu whole body (WB) planar and SPECT/CT scans

Differences in Postoperative Symptoms With Four Ureteral Stents

This is a prospective randomized controlled trial designed to assess the differences in postoperative symptoms related to placement of a 6Fr Percuflex ureteral stents, 6Fr Tria ureteral stents, 4.8Fr Percuflex ureteral stents, and 4.8Fr Tria ureteral...

DEVICE: 6Fr Percuflex ureteral stents

DEVICE: 6Fr Tria ureteral stents

DEVICE: 4.8Fr Tria ureteral stents

DEVICE: 4.8Fr Percuflex ureteral stents

Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical T...

This randomized, controlled, pivotal study is intended to determine whether up to ten sequential 24-hour treatments with the Selective Cytopheretic Device (SCD) will improve survival in patients with Acute Kidney Injury (AKI) requiring continuous kid...

DEVICE: Selective Cytopheretic Device

OTHER: Standard of Care

A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Sol...

The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or Pembrolizumab), and ...

BIOLOGICAL: TRK-950

DRUG: Irinotecan

DRUG: Leucovorin

DRUG: 5-FU

DRUG: Gemcitabine

DRUG: Cisplatin

DRUG: Carboplatin

DRUG: Ramucirumab

DRUG: Paclitaxel

DRUG: Nivolumab

DRUG: Pembrolizumab

DRUG: Imiquimod Cream

DRUG: Bevacizumab

DRUG: PLD

Study for Desensitization of Chronic Kidney Disease in Adult Patients in Need of a Kidney Transplant...

The primary objective of the study is to assess the safety and tolerability of REGN5459 (Part A) or REGN5458 (Part B) as monotherapy in patients with chronic kidney disease (CKD) who need kidney transplantation and are highly sensitized to human leuk...

DRUG: REGN5459

DRUG: REGN5458

Protein Sources Urinary Stone Risk

Prior studies have shown that the source of dietary protein can have a significant impact on urinary stone risk. However, whey and plant protein isolates have not been compared. This is an important distinction as protein supplements fortified foods ...

DIETARY_SUPPLEMENT: Protein

A Study to Evaluate the Safety and Efficacy of Zanubrutinib in Participants With Primary Membranous ...

The primary objectives of this study are: In Part 1 to evaluate the efficacy of zanubrutinib as measured by proteinuria reduction, and in Part 2 to evaluate the efficacy of zanubrutinib compared with tacrolimus as measured by complete remission rate,...

DRUG: Zanubrutinib

DRUG: Tacrolimus

DRUG: Zanubrutinib

Bintrafusp Alfa (M7824) and NHS-IL12 (M9241) Alone and in Combination With Stereotactic Body Radiati...

Background: Genitourinary cancers are some of the most common types of cancer. They are lethal when they spread. The drug M7824 blocks the paths that cancer cells use to stop the immune system from fighting cancer. The drug M9241 triggers the immune...

DRUG: M7824

DRUG: M9241

RADIATION: Stereotactic body radiation therapy (SBRT)

Phase 1b/2 Trial of Ipilimumab, Nivolumab, and Ciforadenant (Adenosine A2a Receptor Antagonist) in F...

To learn if the combination of ciforadenant, ipilimumab, and nivolumab can help to control advanced renal cell carcinoma

DRUG: Ipilimumab

DRUG: Nivolumab

DRUG: Ciforadenant

A Multi-center Study to Evaluate the Safety, Tolerability and Efficacy of TIN816 in Patients at Risk...

This is a randomized, multi-centric, placebo-controlled, participant and investigator-blinded study to evaluate the safety, tolerability and efficacy of TIN816 in adult patients at risk for acute kidney injury following cardiac surgery.

DRUG: TIN816

OTHER: Placebo

Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR S...

This phase III trial compares the effect of stero-ablative radiotherapy (SAbR) followed by standard of care systemic therapy, to standard of care systemic therapy alone, in patients with kidney cancer that has spread from where it first started (prim...

PROCEDURE: Computed Tomography

PROCEDURE: Magnetic Resonance Imaging

OTHER: Questionnaire Administration

PROCEDURE: Stereotactic Ablative Radiotherapy

PROCEDURE: Systemic Therapy

Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors

This is a Phase 1/1b, open-label, first-in-human, dose-escalation and expansion study of CHS-388, a monoclonal antibody that targets IL-27, as a monotherapy and in combination in patients with solid tumors.

DRUG: CHS-388

DRUG: Pembrolizumab

DRUG: Toripalimab

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

Background: * Membranous nephropathy is associated with damage to the walls of the glomeruli, the small blood vessels in the kidneys that filter waste products from the blood. This damage causes leakage of blood proteins into the urine and is associ...

DRUG: Rituximab Infusion

DRUG: Oral Cyclosporine

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Part...

This trial will evaluate efficacy, safety, and tolerability of subcutaneous (s.c.) ianalumab given every 4 weeks (q4w) or every 12 weeks (q12w) compared to placebo, in combination with SoC, in adult participants with active LN

DRUG: ianalumab s.c. q4w

DRUG: ianalumab s.c. q12w

DRUG: placebo s.c.

Evaluation of the Effects of Ketorolac Dose on Duration of Analgesia in Emergency Department (ED) Re...

This is a prospective interventional study examining the effect of ketorolac at doses of 15mg versus 30 mg for duration of analgesia in emergency department patients with suspected renal colic.

DRUG: Ketorolac

Phase 3 Study of Anifrolumab in Adult Patients With Active Proliferative Lupus Nephritis

The purpose of this study is to evaluate the efficacy and safety of IV antifrolumab in adult patients with Active Proliferative Lupus Nephritis

DRUG: Anifrolumab

DRUG: Placebo

Study of CAR.70-engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodep...

To find a recommended dose of donated NK cells that can be given with lymphodepleting chemotherapy to patients with advanced renal cell carcinoma, mesothelioma, or osteosarcoma. The effects of this therapy will also be studied.

DRUG: CAR.70/IL15-transduced CB-derived NK cells

DRUG: Fludarabine phosphate

DRUG: Cyclophosphamide

GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in A...

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-101/GI-101A as a single agent or in combination with pembrolizumab, lenvatinib or local radiotherapy (RT) over a range of advanced and...

DRUG: GI-101

DRUG: Pembrolizumab (KEYTRUDA®)

DRUG: Lenvatinib

RADIATION: Local Radiotherapy

DRUG: GI-101A

DePTH: De-emphasize PTH

The De-emphasize Parathyroid Hormone (DePTH) Study is a 12-month pragmatic, randomized, parallel-group, active comparator, open-label, blinded end-point study of 90 patients with incident or prevalent secondary hyperparathyroidism and kidney failure ...

DRUG: Oral calcitriol with cinacalcet rescue

DRUG: IV activated vitamin D

A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and ...

The main purpose of this study is to investigate the effect of retatrutide on renal function in participants with overweight or obesity and chronic kidney disease (CKD), with or without Type 2 Diabetes (T2D). The study will last around 31 weeks.

DRUG: Retatrutide

DRUG: Placebo

Cryaoablation Assisted Partial Nephrectomy a Non Ischemic Approach

Patients with renal masses eligible to partial nephrectomy often require arterial ischemia to control or prevent blood loss during this surgical procedure. This study aims to determine the safety and efficacy of renal cryoablation at the tumor bed, a...

DEVICE: Cryoablation Assisted Partial Nephrectomy

Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients

Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality. Because acid retention is common in KTRs, it is ...

DRUG: Sodium bicarbonate

DRUG: Placebo

A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treat...

The purpose of this study is to evaluate the drug levels, efficacy, safety, and tolerability of subcutaneous nivolumab versus intravenous nivolumab in participants with previously treated clear cell renal cell carcinoma that is advanced or has spread...

BIOLOGICAL: Nivolumab and rHuPH20

BIOLOGICAL: Nivolumab

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymph...

This phase II Pediatric MATCH treatment trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or does not re...

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Marrow Aspiration and Biopsy

PROCEDURE: Bone Scan

PROCEDURE: Computed Tomography

DRUG: Ensartinib

OTHER: Laboratory Biomarker Analysis

PROCEDURE: Magnetic Resonance Imaging

OTHER: Pharmacological Study

PROCEDURE: Positron Emission Tomography

PROCEDURE: Radionuclide Imaging

PROCEDURE: X-Ray Imaging

Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

The primary objective of this study is to determine the effects of semaglutide on kidney oxygenation and function in type 1 diabetes. The secondary objective is to determine the glycemic effects and safety of semaglutide in type 1 diabetes.

DRUG: Semaglutide

OTHER: Placebo

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

This phase II trial studies the effects of combination therapy with bevacizumab, erlotinib, and atezolizumab in treating patients with hereditary leiomyomatosis and kidney cancer that may have spread from where it first started to nearby tissue, lymp...

BIOLOGICAL: Atezolizumab

BIOLOGICAL: Bevacizumab

PROCEDURE: Biopsy

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

PROCEDURE: Computed Tomography

PROCEDURE: Computed Tomography with Contrast

DRUG: Erlotinib

PROCEDURE: Magnetic Resonance Imaging

PROCEDURE: Positron Emission Tomography

DRUG: Sodium Fluoride F-18

Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Ki...

This is a single center, non-randomized, non-controlled open-label phase 1b/2a trial of performing sequential αβdepleted-HSCT and KT in patients requiring KT to prevent kidney rejection post-KT, in the absence of any post-KT immunosuppression, to abr...

DRUG: Cyclophosphamide 1200 mg/Kg

DRUG: Fludarabine

DRUG: Cyclophosphamide 100 mg/Kg

RADIATION: Total Body Irradiation

DRUG: ATG

DRUG: Rituximab

DRUG: Melphalan

DEVICE: CliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System

PROCEDURE: Kidney Transplant

A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients

This study is being done to determine the effectiveness of using a combination of two different drugs in preventing the transmission of HCV from a HCV positive donor to a HCV negative solid organ recipient.

DRUG: Mavyret

Retro-active Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-identical Ki...

The study seeks to determine if patients with a pre-existing, well-functioning kidney transplant from a HLA-identical living donor can be withdrawn from immunosuppressive medications without compromising allograft function through hematopoietic stem ...

COMBINATION_PRODUCT: Conditioning and Stem cell infusion

"Embolization Before Ablation of Renal Cell Carcinoma (EMBARC)"

Multi-center, single arm, prospective trial to estimate safety, feasibility, technical outcomes, and clinical outcomes of percutaneous cryoablation with neo-adjuvant trans-arterial embolization of the tumor in patients with T1b renal cell carcinoma. ...

PROCEDURE: Trans-arterial embolization (TAE)

A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effective...

A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know. In this study, they are learning the effects of azeliragon patients hospitalized for COVID-19 or pneumonia.

DRUG: Azeliragon

DRUG: Placebo

Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in K...

Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the most common cause of dea...

DRUG: Dapagliflozin 10mg Tab

DRUG: Placebo

Obstruction of Malignancy: Percutaneous Renal vs Endoscopic Stent

This research study will compare two procedures commonly used to treat urinary obstruction due to cancer. Sometimes cancer blocks one or both ureters (narrow tubes in the body that carry urine from the kidneys to the bladder). When these ureters beco...

PROCEDURE: Ureteral Stent

PROCEDURE: Percutaneous Nephrostomy Tube Placement

Neoadjuvant Lenvatinib and Pembrolizumab for IVC Tumor Thrombus

This study will be evaluating safety and efficacy of the combination of lenvatinib and pembolizumab neoaadjuvant therapy prior to surgical resection of locally advanced renal cell carcinoma with IVC tumor thrombus.

DRUG: Neoadjuvant Lenvatinib

DRUG: Neoadjuvant Pembrolizumab

PROCEDURE: Radical nephrectomy, IVC thrombectomy, retroperitoneal lymph node dissection

DRUG: Adjuvant Pembrolizumab

Feasibility of Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease

The investigator proposes a pilot randomized clinical trial to determine the safety and tolerability of empagliflozin in ADPKD patients. To achieve this, the investigator will conduct a 12-month parallel-group, randomized, double-blind, placebo-contr...

DRUG: Empagliflozin

DRUG: Placebo

Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.

This research is being done to better understand the impact of the use of a specific physical activity training program (GH Method) in dialysis/kidney disease patients.

OTHER: Muscle Therapy

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

This study will evaluate safety, pharmacodynamics and biomarkers of subcutaneous (SC) DK210(EGFR) given as monotherapy and in combination with immunotherapy, chemotherapy or radiation.

BIOLOGICAL: DK210 (EGFR)

RADIATION: Radiation therapy

BIOLOGICAL: Immune checkpoint blockers

DRUG: Chemotherapy

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Based on the overwhelming positive response to this survey and the large number of patients being treated with PD-1/PD-L1 therapy in the UPMC system, the investigators are proposing a trial that will randomize patients who have disease stability to s...

DRUG: Continue PD-1/PD-L1 Inhibitors treatment

OTHER: Discontinue PD-1/PD-L1-1 inhibitor

Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD

The purpose of this study is to find out if empagliflozin, a new diabetic medication that has been shown to be very effective in lowering the risk of heart failure, is safe and tolerated in dialysis patients. In the recent years, empagliflozin has be...

DRUG: Empagliflozin

OTHER: Placebo

Neoadjuvant Pembrolizumab and Lenvatinib for Renal Cell Carcinoma

This study will evaluate the effect of investigational drugs, pembrolizumab alone or pembrolizumab with lenvatinib, on the immune systems response to kidney cancer when given before and after surgery to remove kidney cancer.

DRUG: Pembrolizumab infusion

DRUG: Lenvatinib tablet

A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants ...

The purpose of this study is to assess the safety, tolerability, and recommended dose(s) of BMS-986340 as monotherapy and in combination with nivolumab or docetaxel in participants with advanced solid tumors. This study is a first-in-human (FIH) stud...

DRUG: BMS-986340

DRUG: BMS-936558-01

DRUG: Docetaxel

Pain Reduction Using NEurostimulation Study

This is a 4-year project to see if a small battery-powered, device attached to a headband, that sits on the skin surface and delivers what is a hardly noticeable level of electrical stimulation can reduce pain in patients who receive hemodialysis on ...

DEVICE: Active tDCS

DEVICE: Sham tDCS

Impact of Envarsus XR® on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile

This will be a single center, prospective, open-label, randomized, controlled trial comparing Envarsus XR® to twice-daily tacrolimus. The targeted population will be patients with end stage renal disease listed for primary solitary kidney transplant....

DRUG: Tacrolimus

DRUG: Envarsus XR

Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequat...

The purpose of this study is to evaluate the effect of zilebesiran as add-on therapy in patients with high cardiovascular risk and hypertension not adequately controlled by standard of care antihypertensive medications.

DRUG: Zilebesiran

DRUG: Placebo

High Powered Stone Dusting vs. Fragmentation and Basketing at Time of Ureteroscopy

The purpose of this study is to determine the differences in stone free results, patient side effects, and patient satisfaction between dusting vs. basket extraction for kidney and ureteral stones (a kidney stone located in the tube between the kidne...

PROCEDURE: Dusting

PROCEDURE: Basket extraction

Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT

Prismocitrate 18 is a continuous renal replacement therapy (CRRT) solution to be used as a renal replacement solution and as an anticoagulant to prevent blood clotting in the extracorporeal circuit. The objectives of this study are: 1) to confirm th...

DRUG: Prismocitrate 18

Letermovir (Prevymis) for CMV in Kidney and Pancreas Transplant Recipients

This study is designed to assess how effective letermovir is in preventing recurrence of cytomegalovirus (CMV) infection in adult kidney or kidney/pancreas transplant recipients who are UW Health patients. Participants will be in the study for about ...

DRUG: Letermovir

DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers

This phase Ib trial studies the side effects and best dose of DS3201 when given together with and ipilimumab for the treatment of patients with prostate, urothelial, or renal cell cancer that has spread to other places in the body (metastatic). DS320...

BIOLOGICAL: Ipilimumab

DRUG: Valemetostat

Phase 1a/1b Study of STK-012 Monotherapy and in Combination With Pembrolizumab in Patients With Soli...

This is a first-in-human, phase 1a/1b, multicenter, open-label, dose escalation study of STK-012 as monotherapy and in combination with pembrolizumab in patients with selected advanced solid tumors.

DRUG: STK-012

DRUG: Pembrolizumab

Argyle Safety Fistula Cannula With Anti-reflux Valve Clinical Study

The purpose of the investigation is to confirm the safety and performance of the Argyle™ Safety Fistula Cannula with Anti-reflux Valve for hemodialysis treatment.

DEVICE: Argyle Safety Fistula Cannula with Anti-Reflux Valve

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediat...

Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This research study uses special immune system cells called AGAR T cells, a new experimental treatmen...

GENETIC: AGAR T cells

Sacituzumab Govitecan With or Without Atezolizumab Immunotherapy in Rare Genitourinary Tumors (SMART...

Background: Rare tumors of the genitourinary (GU) tract can appear in the kidney, bladder, ureters, and penis. Rare tumors are difficult to study because there are not enough people to conduct large trials for new treatments. Two drugs-sacituzumab g...

DRUG: Sacituzumab govitecan

DRUG: Atezolizumab

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impair...

This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate...

DRUG: balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg

DRUG: balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg

DRUG: dapagliflozin 10 mg and matching placebo for balcinrenone/dapagliflozin

Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malig...

A first-in-human study using BDC-3042 as a single agent and in combination with cemiplimab in patients with advanced malignancies

DRUG: BDC-3042

DRUG: Cemiplimab

A Study of MGC026 in Participants With Advanced Solid Tumors

The study is designed to understand the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of MGC026 in participants with relapsed or refractory, unresectable, locally advanced or metastatic solid tumors The st...

BIOLOGICAL: MGC026 Dose Escalation

BIOLOGICAL: MGC026 Dose for Expansion

Nafamostat Efficacy in Phase 3 Registrational CRRT Study

A prospective, randomized, placebo-controlled clinical study to investigate the safety and efficacy of Niyad (nafamostat mesylate) for anticoagulation of extracorporeal blood circulating through a dialysis filter in patients undergoing CRRT who canno...

DEVICE: Niyad (nafamostat mesylate)

DEVICE: Placebo (0.9% NaCl)

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

The purpose of this study is to assess the safety and tolerability of XmAb®819 administered intravenous (IV) or subcutaneous (SC) in subjects with relapsed or refractory clear cell renal cell carcinoma and to identify the minimum safe and biologicall...

BIOLOGICAL: XmAb819

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders

The main purpose of this study is to examine the outcome of a combined bone marrow and kidney transplant from a partially matched related (haploidentical or "haplo") donor. This is a pilot study, you are being asked to participate because you have a ...

PROCEDURE: Haploidentical Bone Marrow/Kidney

Liberation From Acute Dialysis

The goal of the LIBERATE-D clinical trial is to improve outcomes for patients recovering from dialysis-requiring acute kidney injury (AKI-D). The impact of a conservative dialysis strategy compared to standard clinical practice of thrice-weekly dialy...

PROCEDURE: Dialysis

A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)

Children with steroid resistant nephrotic syndrome (SRNS) are exposed to prolonged courses of immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent need to identify novel ...

DEVICE: trascutaneous auricular vagus nerve stimulation

DEVICE: Sham device

Obinutuzumab in Treatment of Fibrillary Glomerulonephritis

The purpose of this research is to learn if Obinutuzumab is effective and safe in treating patients with fibrillary glomerulonephritis (FGN).

DRUG: Obinutuzumab

Atacicept in Subjects With IgA Nephropathy

A Phase 3 Study with Atacicept in Subjects With IgA Nephropathy (ORIGIN 3)

BIOLOGICAL: Atacicept

OTHER: Placebo to match Atacicept

Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcin...

This is a Phase 1 dose escalation study following a 3+3 study design. The purpose of the TRAVERSE study is to assess the safety, efficacy, and cell kinetics of ALLO-316 in adults with advanced or metastatic clear cell renal cell carcinoma after a lym...

GENETIC: ALLO-316

BIOLOGICAL: ALLO-647

DRUG: Fludarabine

DRUG: Cyclophosphamide

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mut...

This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by bl...

PROCEDURE: Biospecimen Collection

PROCEDURE: Computed Tomography

PROCEDURE: Magnetic Resonance Imaging

DRUG: Olaparib

A Study of Participant Reported Preference for Subcutaneous Pembrolizumab Coformulated With Hyaluron...

The purpose of this study is to evaluate participant preference for coformulated hyaluronidase/pembrolizumab (MK-3475A) administered subcutaneously (SC) over pembrolizumab (MK-3475) administered intravenously (IV) in participants with multiple tumor ...

BIOLOGICAL: Pembrolizumab co-formulated with hyaluronidase

BIOLOGICAL: Pembrolizumab

Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

This is a prospective, multi-center, two-arm, randomized trial to quantify the performance of the EchoMark®/EchoSure® System for AVF diagnostic ultrasound when used under a protocol of biweekly use for assessing fistula maturation and reducing time t...

DEVICE: EchoMark/EchoSure

PROCEDURE: Standard of Care

KYSA-1: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With...

A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects With Refractory Lupus Nephritis

BIOLOGICAL: KYV-101 anti-CD19 CAR-T cell therapy

DRUG: Standard lymphodepletion regimen

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advan...

To assess: * efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion, primary CNS tumors h...

DRUG: APL-101 Oral Capsules

SAfety of Regional Citrate Anticoagulation (SARCA Study)

This is an Open-label, Prospective, Multicenter Study to Assess the SAfety of Regional Citrate Anticoagulation Delivered by the multiFiltratePRO system in Adult Patients Requiring Continuous Renal Replacement Therapy (SARCA Study).

COMBINATION_PRODUCT: Dialysis

Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

The objectives of this study are to evaluate the safety and efficacy of ravulizumab administered by intravenous (IV) infusion compared to placebo and demonstrate proof-of-concept of the efficacy of terminal complement inhibition in participants with ...

DRUG: Ravulizumab

DRUG: Placebo

OTHER: Background Therapy

A Study to Evaluate TOUR006 in Patients With Chronic Kidney Disease and Elevated Hs-CRP

This study will evaluate the safety, tolerability, pharmacokinetics, and CRP-lowering effect of quarterly and monthly subcutaneous administration of TOUR006 in participants with chronic kidney disease and elevated hs-CRP.

DRUG: TOUR006 - 50 MG

DRUG: TOUR006 - 25 MG

DRUG: TOUR006 - 15 MG

OTHER: Placebo

Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney dise...

BEHAVIORAL: Combination Exercise

A Dose Escalation Study of FP-045 in Patients With Fanconi Anemia

This is a multi-center, Phase 1/2 study to determine the Optimal Biologic Dose (OBD) and to evaluate the safety, tolerability, PK, and preliminary activity of FP 045 when administered orally in young adult/adolescent and pediatric patients with Fanco...

DRUG: FP-045

A Multiple-Dose Study of Bulevirtide in Participants With Normal and Impaired Renal Function

The goals of this study are to compare the amount of study drug, bulevirtide (BLV), that gets into the bloodstream and how long it takes for the body to eliminate it, measure the effect of BLV on bile acids, and evaluate the safety and tolerability o...

DRUG: Bulevirtide (BLV)

Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pr...

Risk of cardiovascular diseases (CVD) is significantly elevated in patients with chronic kidney disease (CKD); however, this increased risk is only partially explained by traditional CV risk factors. Arterial dysfunction is an important nontraditiona...

DRUG: Nicotinamide riboside

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adul...

This study aims to evaluate the efficacy and safety of crovalimab in adult and adolescent participants with aHUS.

DRUG: Crovalimab

ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE

The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent ...

DRUG: Placebo

DRUG: Ravulizumab

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy. Eligible ADHF patie...

DEVICE: Aortix System

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab ...

This phase Ib trial tests the safety, side effects, and best dose of tumor treating fields therapy in combination with either cabozantinib or nab-paclitaxel and atezolizumab in treating patients with solid tumors involving the abdomen or thorax that ...

BIOLOGICAL: Atezolizumab

DRUG: Cabozantinib S-malate

DRUG: Nab-paclitaxel

PROCEDURE: Tumor Treating Fields Therapy

Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome

The investigators are piloting a 3 month community-based lifestyle medicine program that incorporates experiences and education in urban agriculture, nutrition, culinary arts, and physical fitness to test the hypothesis whether this improves clinical...

BEHAVIORAL: Lifestyle Medicine Program

BEHAVIORAL: Medically Tailored Groceries

Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nep...

The ASSIST study is a phase 2, double-blind, placebo-controlled crossover study to evaluate the safety and efficacy of atrasentan vs. placebo in subjects with IgA nephropathy (IgAN) while on background standard of care therapy and an SGLT2 inhibitor ...

DRUG: Atrasentan

DRUG: Placebo

Daratumumab to Treat Active Lupus Nephritis

The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in patients with active lupus nephritis.

DRUG: Daratumumab

Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia

Congenital lower urinary tract obstruction (LUTO) is a heterogeneous group of congenital anomalies that lead bladder outlet obstruction. If a complete obstruction is present, the perinatal mortality is estimated to be as high as 90% because of severe...

DRUG: Lactated Ringers Solution for Injection

Savolitinib Plus Durvalumab Versus Sunitinib and Durvalumab Monotherapy in MET-Driven, Unresectable ...

A clinical trial to compare the effectiveness of savolitinib plus durvalumab versus sunitinib in MET-driven (hepatocyte growth factor receptor), unresectable and locally advanced or metastatic PRCC (Papillary Renal Cell Carcinoma).

DRUG: savolitinib

DRUG: durvalumab

DRUG: sunitinib

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Caboz...

This phase II trial studies whether adding radium-223 dichloride to the usual treatment, cabozantinib, improves outcomes in patients with renal cell cancer that has spread to the bone. Radioactive drugs such as radium-223 dichloride may directly targ...

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

DRUG: Cabozantinib S-malate

PROCEDURE: Computed Tomography

PROCEDURE: Magnetic Resonance Imaging

PROCEDURE: Positron Emission Tomography

OTHER: Quality-of-Life Assessment

OTHER: Questionnaire Administration

RADIATION: Radium Ra 223 Dichloride

A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overwe...

This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their w...

DRUG: survodutide

DRUG: Placebo

Islet Transplantation in Type 1 Diabetic Kidney Allograft

The purpose of this study is to learn about the safety of islet transplantation when performed after kidney transplantation, which may provide more normal control of blood sugar without the need for insulin shots. Islets are special clusters of cells...

BIOLOGICAL: Allogenic islet cells (human, U. Chicago)

PROCEDURE: Intraportal infusion of islet cells

Locally Ablative TherapY in Oligo-ProgressiVe GEnitourinary TumoRs (LAYOVER)

This is a phase 2 pragmatic study that evaluates the clinical benefit of continuing systemic therapy with the addition of locally ablative therapies for oligo-progressive solid tumors as the primary objective. The primary outcome measure is the time ...

DEVICE: Ablative local therapy

A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Diseas...

This study is a single center, prospective exploratory pilot study of Sickle Cell Anemia (SCA) participants. The study will enroll patients with early stages of sickle cell nephropathy (Chronic Kidney Disease (CKD) stage 1 or 2) who are at the highes...

DRUG: Voxelotor

Ureteroscopic Laser Modality on Total Lasing Time and Total Energy in Patients With Large, Dense Ren...

This study will examine the effects of ureteroscopic lasing technique (dusting, fragmentation and a hybrid approach) on total lasing time and total energy in patients with a large renal calculi burden of single or multiple stones with the sum of its ...

DEVICE: MOSES laser system

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid ...

A Phase 1, open label, dose escalation and expanded cohort study of P-MUC1C-ALLO1 in adult subjects with advanced or metastatic epithelial derived solid tumors, including but not limited to the tumor types listed below.

BIOLOGICAL: P-MUC1C-ALLO1 CAR-T cells

DRUG: Rimiducid

A Phase II Study Bolstering Outcomes by Optimizing Immunotherapy Strategies With Evolocumab and Nivo...

To learn if evolocumab and nivolumab can control metastatic and refractory renal cell carcinoma. The safety of this drug combination will also be studied.

DRUG: Evolocumab

DRUG: Nivolumab

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid...

3CAR is being done to investigate an immunotherapy for patients with solid tumors. It is a Phase I clinical trial evaluating the use of autologous T cells genetically engineered to express B7-H3-CARs for patients ≤ 21 years old, with relapsed/refract...

DRUG: Fludarabine

DRUG: Cyclophosphamide

DRUG: MESNA

DRUG: B7-H3 CAR T cells

National Institute of Diabetes and Digestive Kidney Diseases* Share Plus: Continuous Glucose Monitor...

The purpose of this study is to test the Share plus intervention aimed at improving the use of data sharing between people with diabetes and their care partners in order to maximize the benefits of continuous glucose monitoring. Hypothesis: Compared...

BEHAVIORAL: Share plus intervention

BEHAVIORAL: Control group

To Compare the Efficacy and Safety of the HAV With AVF in Female Patients With End-Stage Renal Disea...

The goal of this clinical trial is to compare the number of catheter-free days (CFD) and the rate and severity of any dialysis access-related infections between the HAV and AVF groups over 12 months in patients with end-stage renal disease (ESRD) nee...

BIOLOGICAL: HAV

OTHER: AVF

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or ...

This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 for the treatment of patients with radiographically-confirmed progression of Astrocytoma IDH-...

DRUG: NEO212 Oral Capsule

DRUG: Ipilimumab

DRUG: Pembrolizumab

DRUG: Nivolumab

DRUG: Regorafenib

DRUG: Carboplatin

DRUG: Paclitaxel

DRUG: FOLFIRI Protocol

DRUG: Bevacizumab

An Open-label Study of Povetacicept (ALPN-303) in Autoimmune Kidney Diseases

The goal of this clinical study is to evaluate multiple dose levels of povetacicept (ALPN-303) in adults with immunoglobulin A (IgA) nephropathy, membranous nephropathy, lupus-related kidney disease (lupus nephritis). or anti-neutrophil cytoplasmic a...

DRUG: povetacicept

Renal Denervation + PVI vs PVI Alone for Persistent AF

Pulmonary vein isolation (PVI) is the cornerstone of ablation for atrial fibrillation (AF). Increased cardiac sympathetic stimulation can facilitate AF and reduction can be accomplished by renal artery denervation (RDN). The recently completed random...

DEVICE: catheter ablation

DEVICE: renal artery denervation

CAR-T Cell Therapy for Desensitization in Kidney Transplantation

This research study is for people who have been waiting for a kidney transplant for at least one year, and who have a cPRA of 99.5% or higher. Having a cPRA of 99.5% or higher means that your immune system would reject 99.5% of kidneys available for ...

DRUG: Cyclophosphamide

BIOLOGICAL: CART-BCMA

BIOLOGICAL: huCART19

DRUG: Fludarabine

Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease

The goal of this study is to learn if a clinical trial of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is possible in youth with chronic kidney disease (CKD). The investigators also plan to explore whether treatment with SGLT2i (Empagliflozin)...

DRUG: Empagliflozin 10 MG

A Study of CDX-585 in Patients With Advanced Malignancies

This is an open-label, non-randomized, multicenter, dose-escalation and expansion study in patients with selected solid tumors.

DRUG: CDX-585

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinu...

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

DRUG: VX-147

DRUG: Placebo

Vonafexor ALPort Syndrome Efficacy & Safety TRIAl-1 (ALPESTRIA-1)

This study is a proof-of-concept trial of vonafexor safety, its effects on kidney function in subjects with at risk of progression Alport syndrome.

DRUG: Vonafexor

Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOS...

This multicenter, prospective, single-arm clinical study will evaluate the probable benefit and safety of the LIPOSORBER® LA-15 System for the treatment of adult patients with nephrotic syndrome associated with primary focal segmental glomerulosclero...

DEVICE: LIPOSORBER® LA-15

Sit Less, Interact and Move More (SLIMM) 2 Study

* Prolonged sitting (sedentary behavior) is a risk factor for decreased kidney function, obesity, diabetes and mortality. Prolonged sitting is associated with decreased kidney function and increased risk of diabetes, heart disease and death. * In a p...

BEHAVIORAL: SLIMM

BEHAVIORAL: Standard Resistance Training

BEHAVIORAL: Guided Resistance Training

DRUG: Placebo

DRUG: Semaglutide

A Study of Etelcalcetide in Pediatric Subjects With Secondary Hyperparathyroidism and Chronic Kidney...

This is a Phase 3 Study of Etelcalcetide in Pediatric Subjects With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

DRUG: Etelcalcetide

A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma

CyberKnife Based Radiosurgery is a way to deliver large doses of radiation very accurately to a tumor. The ability of this technology to minimize radiation dose to organs adjacent to the target tumor allows a high dose to be delivered to the tumor, t...

DEVICE: CyberKnife

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living...

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or hi...

DRUG: Retatrutide

DRUG: Placebo

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Sev...

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and renal impairment, with inadequate glycemic control on basal insulin alone or a combination of basal insu...

DRUG: Retatrutide

DRUG: Placebo

Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared t...

This is a Phase 1, open-label, single-dose, sequential group study to compare the safety and pharmacokinetics (PK) of pretomanid in the following groups of participants: 1) participants with severe renal impairment including those with end stage rena...

DRUG: PA-824

A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors

The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization...

DRUG: LY4101174

A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes

Diabetic kidney disease remains the leading cause of end-stage kidney disease (ESKD), rising in frequency in parallel with the epidemic of diabetes worldwide. The estimated lifetime risk of kidney disease in persons with type 1 diabetes (T1D) has bee...

DRUG: Fenofibrate

OTHER: Placebo

A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tu...

This is an open-label, multicenter, Phase 1/2 study evaluating the safety and efficacy of CTX131™ in subjects with relapsed or refractory solid tumors.

BIOLOGICAL: CTX131

Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients

Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation. Hemodialysis patients suffer signi...

OTHER: IBPS-Guided Ultrafiltration

Advanced Renal Cell Cancer Combination ImmunoThErapy Clinical Trial

This study is a randomized, open label, multicenter Phase II trial to evaluate the efficacy and safety of botensilimab (a novel Fc enhanced Tree depleting anti-CTLA4) and balstilimab (a novel anti-PD1) relative to ipilimumab and nivolumab in treatmen...

DRUG: Botensilimab

DRUG: Balstilimab

DRUG: Ipilimumab

DRUG: Nivolumab

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

This is a Phase 1a/1b, dose-escalation/expansion, consecutive-cohort, open-label study to evaluate the safety, tolerability, PK, PD, and preliminary evidence of antitumor activity of PLN-101095 in combination with pembrolizumab (the study treatment r...

DRUG: PLN-101095

DRUG: Pembrolizumab

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone i...

This phase III trial compares the usual chemotherapy treatment to eribulin plus gemcitabine in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as eribulin, gemcitabine, docet...

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

PROCEDURE: Computed Tomography

DRUG: Docetaxel

DRUG: Eribulin Mesylate

DRUG: Gemcitabine Hydrochloride

PROCEDURE: Magnetic Resonance Imaging

DRUG: Paclitaxel

BIOLOGICAL: Sacituzumab Govitecan

A Study to Test BI 764198 in People With a Type of Kidney Disease Called Focal Segmental Glomerulosc...

This study is open to adults with a type of kidney disease called focal segmental glomerulosclerosis (FSGS). The purpose of this study is to find out whether a medicine called BI 764198 improves the health of the kidneys in people with FSGS. Three di...

DRUG: BI 764198

DRUG: Placebo

Renal Oxygen Consumption, Insulin Sensitivity, and Daily Caloric Restriction in ADPKD

The proposed research is a pilot study assessing kidney oxidative metabolism and insulin sensitivity after a 2-year weight loss intervention in those with autosomal dominant polycystic kidney disease who are overweight or obese.

BEHAVIORAL: Daily caloric restriction

OTHER: Standard advice control

Deceased Donor Bladder or Combined Kidney-bladder Transplantation: a Phase 0 First-in-human Study

The goal of this clinical trial is to demonstrate the feasibility of bladder transplantation in patients with terminal bladder diseases who would benefit from a new bladder or a combined kidney and bladder transplant. The main questions it aims to an...

PROCEDURE: Bladder Transplantation

PROCEDURE: Combined Kidney and Bladder Transplantation

Combination of Novel Therapies for CKD Comorbid Depression

The overall goal of the study is to determine if treatment of a Major Depressive Disorder (MDD) improves the outcomes of patients with chronic kidney disease (CKD). We showed that MDD is present in 25% of CKD patients and independently associated wit...

DRUG: Bupropion

BEHAVIORAL: Behavioral activation therapy

DRUG: Placebo

OTHER: Clinical Management

Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Condition...

The objective of this clinical trial is to develop a cell therapy for Fanconi Anemia which enables enhanced donor hematopoietic and immune reconstitution with decreased toxicity by transplanting depleted stem cells from a donor after using an experim...

DRUG: JSP191

DEVICE: CliniMACS Prodigy System

BIOLOGICAL: Depleted Stem Cell Transplant

BIOLOGICAL: Rabbit Anti-Thymoglobulin (rATG)

DRUG: Cyclophosphamide

DRUG: Fludarabine

DRUG: Rituximab

Discontinuing CRRT in Patients With Acute Kidney Injury

In this study, investigators are going to test whether a standardize approach to discontinuation of Continuous Renal Replacement Therapy (CRRT) using a set of criteria improves outcomes. These criteria are based on the best available evidence. In a s...

PROCEDURE: Discontinuation of CRRT

Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease

The goal of this study is to better understand the effects of a sodium-glucose transport protein 2 inhibitor, dapagliflozin, added on to standard of care on heart and lung function and circulating metabolites (substances created when our bodies break...

DRUG: Dapagliflozin 10 MG [Farxiga]

Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome

The purpose of this study is to evaluate the platelet count change from baseline and safety of OMS721 in adults and adolescents with atypical hemolytic uremic syndrome (aHUS). The study will also evaluate pharmacokinetics (PK), pharmacodynamics (PD),...

BIOLOGICAL: OMS721

A Study of IMPT-514 in Active Refractory Systemic Lupus Erythematosus (SLE)

This is a Phase 1/2, multi-center, open-label study evaluating the safety and efficacy of IMPT-514, a bispecific chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with active, refractory lupus nephri...

BIOLOGICAL: IMPT-514

A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibit...

Drugs called checkpoint inhibitors help the immune system fight cancer. When the effectiveness of these drugs wears off, it may be possible to renew their effectiveness by combining it with a special type of radiation therapy called stereotactic body...

RADIATION: Stereotactic Body Radiotherapy

BIOLOGICAL: Ipilimumab, Nivolumab, Pembrolizumab or Atezolizumab

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every 12 hours) and (2) pharmacokinetically-guided preci...

DRUG: Mycophenolate Mofetil

A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid...

The goal of this clinical trial is to test the safety and efficacy of KVA12123 alone or combined with pembrolizumab in patients with advanced solid tumors. The main questions this study aims to answer are: 1. What is the safety of KVA12123 when admi...

DRUG: KVA12123 - Dose Escalation

DRUG: KVA12123 Plus Pembrolizumab - Dose Escalation

DRUG: KVA12123 - Dose Expansion

DRUG: KVA12123 Plus Pembrolizumab - Dose Expansion

Safety and Tolerability of FB-001 in Healthy Adult Volunteers and Adult Subjects With Enteric Hypero...

This Phase 1, first-in-human, randomized, double-blinded, placebo controlled study is evaluating FB-001 in healthy volunteers (Part 1) and participants diagnosed with enteric hyperoxaluria (Part 2). Eligible participants receive investigational produ...

BIOLOGICAL: FB-001

BIOLOGICAL: Placebo

A Study to Evaluate Migalastat in Fabry Subjects With Amenable GLA Variant and Renal Disease

An Open-label Study to Evaluate the Safety and Pharmacokinetics of Migalastat HCl in Subjects with Fabry Disease and Amenable GLA Variants and Severe Renal Impairment (SRI) or End Stage Renal Disease (ESRD)

DRUG: migalastat HCl 150 mg

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products d...

BIOLOGICAL: second generation 4-1BBζ EGFR806-EGFRt

BIOLOGICAL: second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG

Stent Omission After Ureteroscopy and Lithotripsy in the Michigan Urological Surgery Improvement Col...

This is a multicenter prospective trial with randomized and observational cohorts assessing patient-reported outcomes and unplanned healthcare utilization following ureteroscopic treatment of renal and ureteral stones, with placement versus omission ...

DEVICE: Standard of care stent placement

OTHER: No stent placement

OTHER: Surveys

Potassium Citrate and Crystal Light Lemonade

To define the effect of crystal light, potassium citrate, or both on urinary stone risk factors in patients with a history of stone and hypocitraturia/low pH

DRUG: Potassium citrate

DRUG: Crystal light

DRUG: Potassium citrate + crystal light

Interstitial Brachytherapy for the Treatment of Unresectable/Unablatable Kidney Cancer

This phase I/II trial investigates the side effects of interstitial brachytherapy and to see how well it works in limiting the growth of large kidney cancer masses in patients with kidney cancer that have refused or are unable to undergo surgery or a...

PROCEDURE: Interstitial Radiation Therapy

A Study of Zetomipzomib (KZR-616) in Patients With Active Lupus Nephritis (PALIZADE)

The purpose of this study is to assess the efficacy and safety of zetomipzomib (30 mg or 60 mg) compared with placebo in achieving renal response after 52 weeks of treatment in patients with active lupus nephritis (LN).

DRUG: zetomipzomib

DRUG: placebo

Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma

This is a multi-site, single arm phase II trial of cabozantinib for IMDC all-risk frontline metastatic renal cell carcinoma (mRCC) patients OR any line mRCC patients who have not previously been treated with cabozantinib.

DRUG: Cabozantinib

DRUG: Nivolumab

A Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxy...

Primary Objectives: To evaluate the safety (compared to iron sucrose) and efficacy of ferumoxytol in pediatric CKD subjects with iron deficiency anemia (IDA) or who are at risk of development of IDA Secondary Objective: To determine the single-dos...

DRUG: Ferumoxytol

DRUG: Iron sucrose

Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC

This research study will assess whether cabozantinib, nivolumab and ipilimumab in combination are safe and effective in slowing down the growth of kidney cancer(renal cell carcinoma or RCC) that has advanced or spread to other areas the body.

DRUG: Cabozantinib

DRUG: Nivolumab

DRUG: Ipilimumab

A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of VX-407 in Healthy Par...

The purpose of the study is to evaluate the safety, tolerability, and pharmacokinetic parameters of VX-407 in healthy participants.

DRUG: VX-407

DRUG: Placebo

DRUG: Midazolam

Incremental Hemodialysis: The TwoPlus Trial

This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function. The study ...

DEVICE: Hemodialysis twice weekly

OTHER: Hemodialysis thrice weekly

Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults ...

The purpose of the study is to evaluate the efficacy, safety and tolerability of balcinrenone/dapagliflozin compared with dapagliflozin alone on patients with chronic kidney disease (CKD) and albuminuria. This study will evaluate the effect of the ba...

DRUG: Balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg

DRUG: Balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg

DRUG: Dapagliflozin 10 mg and matching placebo for balcinrenone/dapa gliflozin

Perioperative Lenvatinib With Pembrolizumab in Patients With Locally Advanced Nonmetastatic Clear Ce...

This phase II trial studies how well lenvatinib and pembrolizumab before surgery work in treating patients with kidney cancer that has spread from its original site of growth to nearby tissues or lymph nodes but has not spread to other places in the ...

DRUG: Lenvatinib

DRUG: Lenvatinib Mesylate

BIOLOGICAL: Pembrolizumab

OTHER: Quality-of-Life Assessment

OTHER: Questionnaire Administration

Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and...

A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrahepatic organ dysfunctions and failures in the pres...

DRUG: VS-01 on top of SOC

OTHER: SOC (Control Group)

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

This is a phase 2, Simon's 2-stage designed study with 2 cohorts of anti-PD-1/PD-L1 experienced patients with untreated brain metastases: 1) melanoma and 2) renal cell carcinoma (RCC).

DRUG: Pembrolizumab

DRUG: Lenvatinib

Low-Dose-Rate Brachytherapy Combined With Immune Checkpoint Inhibition in Cancer

This is a pilot study of combination low dose rate brachytherapy (LDR) added to standard of care (SOC) immunotherapy in stage III and IV melanoma, stage IV renal call cancer, and stage IV urothelial cancer.

RADIATION: Low Dose Rate Brachytherapy (LDR)

DRUG: Standard-of-Care Immunotherapy

A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impai...

The primary purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) of emraclidine following administration of a single oral dose in participants with mild, moderate, and severe renal impairment relative to matc...

DRUG: Emraclidine

A Study to Learn How Well the Treatment Combination of Finerenone and Empagliflozin Works and How Sa...

Finerenone works by blocking a group of proteins, called mineralocorticoid receptor. An increased stimulation of mineralocorticoid receptor is known to trigger injury and inflammation in the kidney and is therefore thought to play a role in CKD. Emp...

DRUG: Finerenone (BAY94-8862 ) 10 mg

DRUG: Empagliflozin

DRUG: Empagliflozin Placebo

DRUG: Finerenone (BAY94-8862 ) 20 mg

DRUG: Finerenone Placebo

A Study of BION-1301 in Adults With IgA Nephropathy

Safety and Efficacy of BION-1301 in Adults with IgA Nephropathy

DRUG: BION-1301

DRUG: Placebo

Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered Wit...

Participants are being asked to take part in this clinical trial, a type of research study, because the participants have a Wilms Tumor cancer. Primary Objectives To determine whether delivery of proton beam radiation to a conformal reduced target ...

DEVICE: Proton Beam Radiation (PBRT)

DRUG: DD-4A Chemotherapy Regimen

PROCEDURE: Complete Surgical Resection

PROCEDURE: Surgical Resection

PROCEDURE: Partial Nephrectomy

Plant-based Diet for Kidney Transplant Recipients

The goal of this clinical trial is to evaluate cardiometabolic and inflammatory parameters in kidney transplant recipients after transitioning to a plant-based diet (PBD). The main aims of the study are as follows: * To test the feasibility of trans...

BEHAVIORAL: Plant-based diet

Patient-driven Management of BP in CKD

The proposed research will evaluate if patients managing their blood pressure medications under the guidance of a clinical pharmacist works better to lower blood pressure than patients monitoring their blood pressure at home and the standard care. 60...

BEHAVIORAL: Self-management of BP medications

BEHAVIORAL: Self-monitoring of home BP

AMSC for Reducing Anastomotic Stenosis in Primary Arteriovenous Anastomoses

Researchers are evaluating the safety of allogeneic Adipose Derived Mesenchymal Stem Cells (AMSC) use during hemodialysis arteriovenous fistula and arterial bypass creation and its efficacy on improving access maturation and primary anastomotic paten...

DRUG: Adipose Derived Mesenchymal Stem Cells

The Home Blood Pressure (BP) Trial

The main study will be a two arm 10-month, cross-over randomized controlled trial of 200 participants treated with end-stage-kidney-disease treated with in-center hemodialysis in the Seattle and San Francisco area comparing a strategy of targeting ho...

OTHER: Dry weight target adjustment

DRUG: Anti-hypertensive medications

Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

This research study involves a combination of three drugs given together as a possible treatment for malignant rhabdoid tumor, atypical teratoid rhabdoid tumor, epithelioid sarcoma, chordoma or other tumors that are deficient in one of two possible p...

DRUG: Tazemetostat

DRUG: Nivolumab

DRUG: Ipilimumab

A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT injections given 3 months (+30 days) apart and delivered percutaneously into biopsied and non-biopsied contralateral kidneys in participants with T...

BIOLOGICAL: Renal Autologous Cell Therapy (REACT)

PROCEDURE: Sham Comparator

An Open-label, Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323 in Severe, Refractor...

The study is intended to assess safety, efficacy and cellular kinetics of YTB323 treatment in participants with severe refractory systemic lupus erythematosus.

DRUG: YTB323

Molecular Residual Disease (MRD) Guided Adjuvant ThErapy in Renal Cell Carcinoma (RCC)

The goal of this Clinical Study is to understand the outcomes by informing therapy choice for adjuvant treatment in clear cell renal cell carcinoma by using molecular residual disease. The main question\[s\] it aims to answer are: * what is the pro...

DRUG: Pembrolizumab injection

Daily Caloric Restriction in ADPKD

This clinical trial will determine whether a daily-caloric restriction-based weight loss intervention can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese. The study will also evaluate changes...

BEHAVIORAL: Daily caloric restriction

OTHER: Standard advice control

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Sol...

The purpose of this study is to evaluate the safety and tolerability of: * AB521 when taken alone in participants with advanced solid tumor malignancies and clear cell renal cell carcinoma (ccRCC) during the dose escalation stage; and * AB521 monoth...

DRUG: AB521

DRUG: Cabozantinib

Safety, Feasibility and Efficacy of Sulforaphane (Avmacol Extra Strength) in Chronic Kidney Disease

The Sulforaphane Production System® in Avmacol Extra Strength (ES) supplies broccoli seed extract (glucoraphanin) and Myrosimax® (Active Myrosinase Enzyme) which helps promote sulforaphane production in your body. The investigators hypothesize that d...

DRUG: Sulforaphane (Avmacol Extra Strength)

DIETARY_SUPPLEMENT: Placebo

Potential Therapeutic Role of Effervescent Calcium-Magnesium Citrate in Chronic Kidney Disease Stage...

The Investigators plan to conduct a long-term trial to explore therapeutic implications of effervescent calcium magnesium citrate (EffCaMgCit) in CKD Stage V (end stage renal disease on hemodialysis). The Investigators will test the hypothesis that E...

DRUG: EffCaMgCit

OTHER: CaAcS

Ertugliflozin in Chronic Heart Failure

The purpose of this study is to determine the effects on heart failure signs and symptoms of the use of either ertugliflozin, metolazone or placebo, in conjunction with intravenous loop diuretic use in acute settings and chronic oral loop diuretic th...

DRUG: Ertugliflozin

DRUG: Metolazone

DRUG: Placebo

Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal ...

This is a pilot, single-center, single-arm study where 20 patients with metastatic or unresectable clear cell renal cell carcinoma will receive same sequential treatment strategy (Cabozantinib for 12 weeks, then proceed with Ipilimumab plus Nivolumab...

DRUG: Cabozantinib

DRUG: Ipilimumab

DRUG: Nivolumab

DRUG: Lenvatinib

DRUG: Everolimus

Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices

The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with complex abdominal aneurysm...

DEVICE: Custom Made Fenestrated or Branched Stent Graft

A Study of SNP-ACTH (1-39) Gel in Patients With Primary Membranous Nephropathy

The goal of the Phase 3a part of this clinical trial is to determine the optimal dose that will be used in the Phase 3b part of this clinical trial. The goal of the Phase 3b part is to assess the efficacy of SNP-ACTH (1-39) Gel relative to rituximab ...

DRUG: SNP-ACTH (1-39) Gel

DRUG: Rituximab

Standard vs Mini-PCNL for the Treatment of Stone Disease

Randomized comparison of patient outcomes following standard PCNL versus mini-PCNL.

PROCEDURE: PCNL

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed). Drugs used in ...

PROCEDURE: Biopsy

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

DRUG: Carboplatin

PROCEDURE: Computed Tomography

DRUG: Cyclophosphamide

DRUG: Doxorubicin

DRUG: Etoposide

DRUG: Ifosfamide

DRUG: Irinotecan

PROCEDURE: Magnetic Resonance Imaging

PROCEDURE: Positron Emission Tomography

RADIATION: Radiation Therapy

PROCEDURE: Surgical Procedure

DRUG: Topotecan

PROCEDURE: Transabdominal Ultrasound

DRUG: Vincristine

PROCEDURE: X-Ray Imaging

A Randomized Trial of Maintenance Systemic Therapy After Radiation for Oligometastatic Renal Cell Ca...

To learn if adding 1 year of therapy with pembrolizumab can help to continue to control RCC after radiation therapy.

DRUG: Pembrolizumab

RADIATION: Radiation therapy

Preop Laxatives in Robotic Urologic Surgery

Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically. Patients undergoing the...

DRUG: Polyethylene Glycol 3350

Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits

The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in people with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID).

DRUG: Daratumumab

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Loc...

This study will evaluate the efficacy, safety, and pharmacokinetics of tobemstomig (also known as RO7247669) in combination with axitinib alone or with tiragolumab (anti-TIGIT) and axitinib, as compared to pembrolizumab and axitinib in participants w...

DRUG: Tobemstomig

DRUG: Tiragolumab

DRUG: Pembrolizumab

DRUG: Axitinib

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

DRUG: Nivolumab

DRUG: Ipilimumab

Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant

Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation? The investigators' mobi...

BEHAVIORAL: mHealth Messaging Intervention Group

Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer,...

This phase II trial compares the effect of atezolizumab in combination with usual treatment with cabozantinib to cabozantinib alone in patients with papillary renal cell carcinoma that has spread to other places in the body (metastatic). Papillary re...

BIOLOGICAL: Atezolizumab

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

DRUG: Cabozantinib S-malate

PROCEDURE: Computed Tomography

The Selective Cytopheretic Device (SCD) for Acute Kidney Injury (AKI) and Hepatorenal Syndrome (HRS)...

This research study is being done to learn what effect 7 days of treatment with the Selective Cytopheretic Device (SCD) will have on these white blood cells in the bloodstream of patients with hepatorenal syndrome and to learn whether it has any effe...

DEVICE: Selective Cytopheretic Device

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Adv...

This phase I trial tests the safety and tolerability of an experimental personalized vaccine when given by itself and with pembrolizumab in treating patients with solid tumor cancers that have spread to other places in the body (advanced). The experi...

DRUG: Cyclophosphamide

BIOLOGICAL: Neoantigen Peptide Vaccine

BIOLOGICAL: Pembrolizumab

BIOLOGICAL: Sargramostim

A Study to Evaluate the Efficacy and Safety of RO7434656 in Participants With Primary Immunoglobulin...

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of RO7434656, a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease d...

DRUG: RO7434656

DRUG: Placebo

Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescent...

OTHER: Infusion of 200% maintenance fluids as balanced crystalloid IV solution

OTHER: Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

This first-in-human (FIH) dose-escalation and dose-validation/expansion study will assess KO-2806, a farnesyl transferase inhibitor (FTI), as a monotherapy and in combination, in adult patients with advanced solid tumors.

DRUG: KO-2806

DRUG: Cabozantinib

DRUG: Adagrasib

TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After...

This study is a comparison of the analgesic efficacy of transversus abdominis plane (TAP) blocks with ropivacaine bolus plus continuous ropivacaine infusion via catheters versus single shot TAP blocks with liposomal bupivacaine.

DRUG: Ropivacaine Continuous Infusion Catheter

DRUG: Single Dose Liposomal Bupivicaine

Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)

In this pragmatic clinical trial, which will dovetail with Veterans' routine outpatient dialysis clinic visits in six VA medical centers, the investigators will study 252 Veterans with kidney disease who need to start dialysis treatment. If a Veteran...

OTHER: Twice-weekly hemodialysis with incremental crossover to thrice-weekly schedule

OTHER: Thrice-Weekly Hemodialysis

A Phase IIb, Multicenter, Open-Label, Prospective Study of Bremelanotide in Diabetic Kidney Disease

This is a prospective, open-label trial to assess the efficacy of melanocortin receptor agonist bremelanotide (BMT) when administered with RAAS inhibition therapy after six months in subjects with Type II diabetic nephropathy. After six months of the...

DRUG: Bremelanotide

DRUG: RAAS inhibition therapy

NSAID Use After Robotic Partial Nephrectomy

The purpose of this study is to see how effective non-steroidal anti-inflammatory drugs (NSAIDs) are at controlling pain without side effects in participants after robotic-assisted partial nephrectomy.

DRUG: Ketorolac

DRUG: Acetaminophen

DRUG: Oxycodone

DRUG: Hydromorphone

DRUG: Ibuprofen

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Adva...

Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with advanced solid tumors.

DRUG: SNS-101 (anti-VISTA)

DRUG: Cemiplimab

A Study of Participants With Chronic Kidney Disease Previously Treated With REACT

The purpose of this study is to evaluate the safety of supplemental REACT injections in participants with chronic kidney disease (CKD) who have previously received REACT treatment.

BIOLOGICAL: Renal Autologous Cell Therapy (REACT)

Enfortumab Vedotin Plus Pembrolizumab for the Treatment of Locally Advanced or Metastatic Bladder Ca...

This phase II trial tests how well enfortumab vedotin (EV) and pembrolizumab works in treating patients with bladder cancer of variant histology (a group of less common types of bladder cancer) that have spread to nearby tissue or lymph nodes (locall...

PROCEDURE: Biospecimen Collection

PROCEDURE: Computed Tomography

DRUG: Enfortumab Vedotin

PROCEDURE: Magnetic Resonance Imaging

BIOLOGICAL: Pembrolizumab

OTHER: Questionnaire Administration

Hemodialysis in the Elderly (70yrs & Older)

This will be a prospective, single institution, parallel-group, single-blinded, randomized-controlled, two-arm, effectiveness study comparing autologous arteriovenous fistula versus hemodialysis access grafts in the elderly. The target sample size wi...

PROCEDURE: Surgical fistula creation from patient's anatomy

DEVICE: Surgical Graft implant

Renal Mechanism of SGLT2 Inhibition

Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA). Canagliflozin acts by increasing salt and sugar loss in the urine, and has shown to protect heart, kidney...

DRUG: canagliflozin

DRUG: Aminohippurate Sodium Inj 20%

Benefit of Transradial Approach in Chronic Kidney Disease Population Undergoing Cardiac Catheterizat...

The investigators will conduct a randomized controlled trial that aims to compare the incidence of contrast-induced nephropathy between transradial- and transfemoral-access cardiac catheterization.

PROCEDURE: Cardiac Catheterization

MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

This single-institution, phase II study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) using busulfan- and fludarabine-based conditioning regimens with busu...

BIOLOGICAL: Stem Cell Transplantation

DRUG: IMD Preparative Regimen

DRUG: Osteopetrosis Only Preparative Regimen

DRUG: Osteopetrosis Haploidentical Only Preparative Regimen

DRUG: cALD SR-A (Standard-Risk, Regimen A)

DRUG: cALD SR-B (Standard-Risk, Regimen B)

DRUG: cALD HR-D (High-Risk, Regimen C)

DRUG: cALD HR-D (High-Risk, Regimen D)

VIBRANT: VIB4920 for Active Lupus Nephritis

This is a multi-center double-blind placebo controlled clinical trial evaluating the efficacy of VIB4920 combined with mycophenolate mofetil (MMF) and prednisone in achieving a renal response in participants with active lupus nephritis (LN).

DRUG: VIB4920

DRUG: Placebo for VIB4920

Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Fu...

The aim of this study is to evaluate nedosiran in participants 11 years of age and younger who have Primary Hyperoxaluria with relatively intact renal function.

DRUG: nedosiran

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherap...

This study is an open-label Phase Ib (Part A) dose escalation followed by a blinded, randomized, multi cohort Phase 2a (Part B) comparison of combination vs. reference regimens. Currently study will only be enrolling the Phase 1b and the Phase 2a pr...

DRUG: Alintegimod

DRUG: Ipilimumab

DRUG: Nivolumab

Angiotensin II in Liver Transplantation

The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.

DRUG: Angiotensin II

DRUG: Saline

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficien...

This phase I/II trial studies how well tiragolumab and atezolizumab works when given to children and adults with SMARCB1 or SMARCA4 deficient tumors that have either come back (relapsed) or do not respond to therapy (refractory). SMARCB1 or SMARCA4 d...

BIOLOGICAL: Atezolizumab

PROCEDURE: Biospecimen Collection

PROCEDURE: Computed Tomography

OTHER: Fludeoxyglucose F-18

PROCEDURE: Magnetic Resonance Imaging

PROCEDURE: Positron Emission Tomography

BIOLOGICAL: Tiragolumab

PROCEDURE: X-Ray Imaging

Concomitant Renal and Urinary Bladder Allograft Transplantation

The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.

PROCEDURE: Concomitant Renal and Urinary Bladder Allograft Transplantation

Safety, Feasibility, and Tolerability of Sulforaphane in Children With Chronic Kidney Disease

This purpose of this study is to investigate potential new therapeutics in pediatric chronic kidney disease (CKD). The specific aims are to identify safe dosing and tolerability of sulforaphane (SFN) supplementation in children with moderate and adva...

DRUG: Sulforaphane

Mindfulness in Chronic Kidney Disease

This study will test whether mindfulness meditation (MM) improves sympathetic function in chronic kidney disease (CKD) and whether transcutaneous vagus nerve stimulation (tVNS) optimizes the sympatho-inhibitory effects of mindfulness meditation (MM) ...

BEHAVIORAL: Mindfulness-based stress reduction (MBSR)

BEHAVIORAL: Health enhancement program (HEP)

DEVICE: Transcutaneous Vagus Nerve Stimulation (tVNS)

DEVICE: Sham-transcutaneous Vagus Nerve Stimulation (tVNS)

Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/-...

The overall purpose of this two-part study is to evaluate the efficacy, safety and tolerability of iptacopan (LNP023) in addition to standard of care treatment.

DRUG: Iptacopan (part 1)

DRUG: Iptacopan (part 2)

DRUG: Placebo + standard of care

DRUG: Iptacopan + placebo

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid T...

This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all p...

DRUG: Ceralasertib

DRUG: Olaparib

DRUG: Durvalumab

Delayed Tolerance Through Mixed Chimerism

This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor). An investigational medication and other treatments will be given prior to and after the transplant to h...

OTHER: Bone Marrow Transplant

PROCEDURE: Peripheral Blood Stem Cell Collection

DRUG: Fludarabine

DRUG: Cyclophosphamide

DRUG: Rituximab

DRUG: Siplizumab

Nivolumab for the Treatment of Patients With Metastatic Urothelial Cancer With ARID1A Mutation and S...

This phase II trial studies the effect of nivolumab in urothelial cancer that has spread to other places in the body (metastatic), specifically in patients with aberrations in ARID1A gene (ARID1A mutation) and correlate with expression level of CXCL1...

OTHER: Diagnostic Laboratory Biomarker Analysis

BIOLOGICAL: Nivolumab

DRUG: Relatlimab

Study of GBT021601 in Participants With Renal Impairment

Renal Impairment study of GBT021601.

DRUG: GBT021601

Clinical Trial To Evaluate Safety And Efficacy Of KT-301 (Formerly US-APR2020) In Subjects With Chro...

The aim of this Phase 2 study is to evaluate the safety and efficacy of the live biotherapeutic product, KT-301 (formerly US-APR2020), in the management of patients with CKD Stage IV.

DRUG: US-APR2020

DRUG: Placebo

Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain ...

This research study is studying two different types of radiation as treatment for brain metastases (tumors in the brain that spread from a cancer that originated elsewhere in the body)

RADIATION: Whole brain radiation

RADIATION: Stereotactic radiation (SRS)

Ferric Citrate and Chronic Kidney Disease in Children

We will conduct a 12-month, double-blind, randomized, placebo-controlled trial to assess the effects of therapy with ferric citrate (FC) on changes in intact FGF23 levels (iFGF23, primary endpoint) in 160 pediatric patients (80 in each of the two arm...

DRUG: Ferric Citrate

DRUG: Placebo

A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilasta...

The primary purpose of this study is to assess the efficacy of oral TBP-PI-HBr as compared with intravenous (IV) imipenem-cilastatin with respect to the overall response (combined clinical cure plus microbiological eradication) at the Test-of-Cure (T...

DRUG: TBP-PI-HBr

DRUG: Imipenem-cilastatin

DRUG: Dummy Infusion

DRUG: Dummy Tablets

A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With A...

The purpose of this study is to test the safety and tolerability of HFB200603 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study. During the escalation part, groups of participa...

DRUG: HFB200603

DRUG: Tislelizumab

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tu...

The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer. The study is conducted in two parts - phase Ia (dose-e...

DRUG: LY4052031

Clinical Outcomes and Healthcare Economics of SOLTIVE Compared to Ho:YAG Laser in Urolithiasis

To compare intraoperative as well as postoperative outcomes of SOLTIVE Thulium laser compared to Ho:YAG laser for the treatment of urolithiasis. The hypothesis is that utilizing the SOLTIVE Thulium laser for the treatment of urolithiasis will result...

DEVICE: SOLTIVE Thulium Fiber Laser

DEVICE: Ho:YAG Laser

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, I...

Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range. Yet, type 1 diabetes is ...

DRUG: Metformin Hcl 1000Mg Tab

DRUG: Aminohippurate Sodium 20 % Injection

DRUG: Iohexol 300 Mg/mL Injectable Solution

DRUG: Placebo

Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study

The long-term objective of this study is to test whether the addition of SGLT2 inhibitors to usual care during acute heart failure management in patients who develop kidney injury shortens the time to achieving symptomatic improvement and kidney func...

DRUG: Dapagliflozin

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

The purpose of this study is to find out whether lattice radiation therapy (LRT) is an effective radiation therapy technique when compared to standard stereotactic body radiation therapy (SBRT). The study will also study how the different radiation t...

RADIATION: Stereotactic body radiotherapy

RADIATION: Lattice Radiation Therapy

A Beta-only IL-2 ImmunoTherapY Study

This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in pati...

DRUG: MDNA11

DRUG: Pembrolizumab (KEYTRUDA®)

A Study of Felzartamab in Participants With Lupus Nephritis

The goal of this clinical trial is to evaluate the safety and tolerability of felzartamab plus standard of care in participants with refractory Lupus Nephritis (LN).

DRUG: Felzartamab

Bone in CKD Alkali Response (BICARb Pilot Trial)

The goal of this clinical trial is to test whether potassium citrate improves skeletal health in adults and children with chronic kidney disease. The main questions it aims to answer are: * To evaluate effects of potassium citrate treatment on bone ...

DRUG: Potassium citrate

DRUG: Placebo

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With A...

This phase II, randomized, double-blind, placebo-controlled study is designed to evaluate the safety, efficacy and pharmacokinetics (PK) of obinutuzumab in adolescent participants (AP) aged 12 to less than 18 with biopsy-confirmed proliferative lupus...

DRUG: Obinutuzumab

DRUG: Placebo

DRUG: Mycophenolate Mofetil

DRUG: Acetaminophen/paracetamol

DRUG: Diphenhydramine hydrochloride (HCl)

DRUG: Methylprednisolone

DRUG: Prednisone

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoi...

This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with t...

PROCEDURE: Biospecimen Collection

PROCEDURE: Dual X-ray Absorptiometry

DRUG: Tegavivint

PROCEDURE: X-Ray Imaging

Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor ...

Background: In a new cancer therapy, researchers take a person s blood, select a certain white blood cell to grow in the lab, and then change the genes of these cells using a virus. The cells are then given back to the person. This is called gene tr...

DRUG: Cyclophosphamide

DRUG: Fludarabine

DRUG: Aldesleukin

BIOLOGICAL: Anti-hCD70 CAR transduced PBL

Defibrotide Dose-escalation for SOS Post-HSCT

This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic cell transplantation (HC...

DRUG: Defibrotide

Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i...

This is a randomized, double-blind (DB), placebo controlled, crossover study with a two-period, two-sequence (2x2) design evaluating the efficacy and safety of 25 mg QD lorundrostat (an aldosterone synthase inhibitor \[ASI\]) in addition to a SGLT2i ...

DRUG: Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QD

DRUG: Placebo QD + SGLT2i QD, Washout, Lorundrostat 25mg+SGLT2i QD

Testosterone Treatment in Men With Chronic Kidney Disease

This study in being conducted in men who have low testosterone and chronic kidney disease. The investigators will evaluate the effects of an oral testosterone preparation, JATENZO, on testosterone levels and hemoglobin (red blood cells).

DRUG: Jatenzo Pill

Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial C...

This research study is an open label study designed to evaluate the safety and translational correlative changes of the combination of propranolol hydrochloride and immune checkpoint inhibitors (ICI) in subjects with urothelial carcinoma.

DRUG: Pembrolizumab

DRUG: Propranolol Hydrochloride

DRUG: Nivolumab

DRUG: Avelumab

CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kid...

This phase I trial tests the safety, side effects, best dose, and effectiveness of CBM588 in combination with nivolumab and ipilimumab in treating patients with kidney cancer that may have spread from where it first started to nearby tissue, lymph no...

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

BIOLOGICAL: CBM588 Capsules

PROCEDURE: Computed Tomography

BIOLOGICAL: Ipilimumab

PROCEDURE: Magnetic Resonance Imaging

BIOLOGICAL: Nivolumab

Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombu...

The primary objective of this study is to evaluate whether the combination of Pembrolizumab and Axitinib given in the neoadjuvant setting can change the Inferior Vena Cava Tumor Thrombus burden. A decrease in the size of the tumor thrombus can potent...

DRUG: Axitinib

DRUG: Pembrolizumab

A Trial of Transplanting Hepatitis C Kidneys Into Hepatitis C-Negative Kidney Recipients

The Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients \[THINKER-NEXT\] study will include adult kidney transplant candidates without hepatitis C virus (HCV) infection on the transplant waiting list who will consent to kidney transplan...

DRUG: Epclusa

A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Th...

The primary objective of this study is to evaluate the safety of tolvaptan in pediatric subjects with autosomal recessive polycystic kidney disease (ARPKD)

DRUG: Tolvaptan Suspension

DRUG: Tolvaptan Tablets

Empagliflozin in ESKD - A Feasibility Study

The aim of this study is to learn about the safety of empagliflozin in dialysis patients as a preparation for a future large clinical trial. Empagliflozin has been approved by the Food and Drug Administration for the treatment of either type 2 diabet...

DRUG: Empagliflozin 25 mg thrice-weekly post-hemodialysis dosing

DRUG: Empagliflozin 10 mg daily dosing

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

To learn if giving tivozanib in combination with nivolumab can help to control advanced nccRCC.

DRUG: Tivozanib

DRUG: Nivolumab

A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Mo...

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and f...

DRUG: Finerenone (Kerendia, BAY94-8862)

DRUG: Placebo

MOSES Lithotripsy Technology Applied to Stone Fragmentation During Ureteroscopy

To determine if the effects of MOSES laser modulation technology can improve the safety and efficiency to laser fragmentation resulting in decreased total laser time, reduced potential for injury to the patient, and total OR time and utilization.

DEVICE: MOSES

ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiov...

This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation. Participants will either get ziltiv...

DRUG: Ziltivekimab B

DRUG: Ziltivekimab C

DRUG: Placebo (Ziltivekimab B)

DRUG: Placebo (Ziltivekimab C)

Autologous Dendritic Cell Vaccine in Kidney Cancer

The purpose of this study is to estimate the probability of immune response for the combination treatment of dendritic cell vaccine with oral cabozantinib and characterize the safety profile of interventional therapy.

BIOLOGICAL: Autologous alpha-DC1/TBVA vaccine

DRUG: Cabozantinib

Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure

Stone disease is a common condition, affecting approximately 9% of Americans in 2007. It causes great morbidity and is also a costly condition, estimated to cost the US healthcare system approximately 3.79 billion dollars in 2007. Ureteroscopy (URS) ...

DRUG: Methocarbamol

DRUG: Oxybutynin

Novel Desensitization Kidney Transplantation

This proposal's objective is to determine whether belatacept, in conjunction with a proteasome inhibitor can be used to safely increase the likelihood of finding an acceptable donor for highly HLA sensitized kidney transplant candidates.

DRUG: Belatacept Injection

The Effect of Sodium-glucose Cotransporter (SGLT) 2 Inhibitors on Cystine Stone Formation: A Prelimi...

Cystinuria is an inherited autosomal recessive disorder of the kidney that is the result of an inability to reabsorb cystine from the urine. Supersaturation of cystine in the urine produces crystals that precipitate and form stones in the kidney, whi...

DRUG: Dapagliflozin

Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With P...

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of intravenous (IV) administration of XmAb808 in combination with pembrolizumab in subjects with selected advanced solid tumors and to identify the minimum safe a...

BIOLOGICAL: XmAb®808

BIOLOGICAL: Keytruda® (pembrolizumab)

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Study QXL138AM-001 is a Phase 1a/1b study to investigate the safety, pharmacokinetics, and preliminary activity of QXL138AM in subjects with locally advanced un-resectable and/or metastatic solid tumors and multiple myeloma. The study is an open-labe...

BIOLOGICAL: QXL138AM Injection every 2 weeks by IV Infusion

Lipid Management in Renal Transplant Recipients Using Evolocumab.

Cardiovascular disease is the leading cause of mortality after renal transplantation, accounting for more than 30% of deaths. Elevated lipid levels (hyperlipidemia) are a frequent finding following transplantation and the immunosuppressive medication...

DRUG: Evolocumab

DRUG: Statins (Cardiovascular Agents)

Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants With Epstein-...

The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of (1) solid...

BIOLOGICAL: tabelecleucel

Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine

This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.

DRUG: Colchicine

DRUG: Placebo

Diuretic Tuner Clinical Decision Support

This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing. P...

DEVICE: Diuretic Tuner

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapa...

This is a Phase III, randomised, multicentre, double-blinded study to evaluate efficacy, safety and tolerability of treatment with zibotentan/dapagliflozin and dapagliflozin alone in participants with chronic kidney disease (CKD) and high proteinuria...

DRUG: Zibotentan/Dapagliflozin

DRUG: Dapagliflozin

Study of WAL0921 in Patients With Glomerular Kidney Diseases

This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and proteinuria, includin...

DRUG: WAL0921

DRUG: Placebo

taVNS for FRNS in Children

Children with frequently relapsing nephrotic syndrome (FRNS) are exposed to prolonged courses of steroids and other immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent n...

DEVICE: Transcutaneous auricular vagus nerve stimulation

DEVICE: Sham device

Diuretics and Volume Overload in Early CKD

Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes. People with CKD have a high risk of cardiovascular (CV) diseases, such as heart attac...

DRUG: Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)

Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney In...

The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting with a diagnosis of sep...

BIOLOGICAL: TIN816 70 mg lyophilisate powder

OTHER: Placebo

A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs

The Sponsor is developing KB707, a replication-defective, non-integrating herpes simplex virus type 1 (HSV-1)-derived vector that is designed to stimulate an anti-tumor immune response through the production of cytokines delivered to the airways of p...

BIOLOGICAL: KB707

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

This study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in idiopathic immune complex mediated membranoproliferative glomerulonephritis.

DRUG: Placebo

DRUG: iptacopan

A Study of LOXO-435 in Participants With Cancer With a Change in a Gene Called FGFR3

The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-435. LOXO-435 may be used to treat cancer of the cells that line the urinary system and other solid tumor cancers that have a change in a partic...

DRUG: LOXO-435

DRUG: Pembrolizumab

The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency ...

The primary purpose of Study INZ701-104 (the ENERGY study) is to assess the safety and tolerability of INZ-701 in infants with ENPP1 Deficiency or with ABCC6 Deficiency.

DRUG: INZ-701

Study of Zanzalintinib (XL092) + AB521 and Zanzalintinib + AB521 + Nivolumab in Participants With Ad...

The goal of this clinical trial is to learn about the safety and preliminary antitumor activity of zanzalintinib in combination with AB521 (doublet) and in combination with AB521 plus nivolumab (triplet) in participants with advanced ccRCC or other a...

DRUG: zanzalintinib

DRUG: AB521

BIOLOGICAL: Nivolumab

NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose, define the pharmacoki...

BIOLOGICAL: NM32-2668

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

To evaluate the safety, efficacy and tolerability of sparsentan oral suspension and tablets, and assess changes in proteinuria after once-daily dosing over 108 weeks.

DRUG: Sparsentan

Eltrombopag for People With Fanconi Anemia

Background: Fanconi anemia is a genetic disease. Some people with it have reduced blood cell counts. This means their bone marrow no longer works properly. These people may need blood transfusions for anemia (low red blood cells) or low platelet cou...

DRUG: Eltrombopag

A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors

Study CP-MGC018-02 is a study of vobramitamab duocarmazine (MGC018) in combination with lorigerlimab (MGD019). The study is designed to characterize safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics, and preliminary antitu...

BIOLOGICAL: vobramitamab duocarmazine

BIOLOGICAL: lorigerlimab

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

Single arm, single site, open-label Phase II study of the effects of oral olaparib in participants with metastatic renal cell carcinoma that harbor an inactivating mutation in BAP-1, ATM, BRCA1, BRCA2, PALB2, CHEK2, BRIP1, RAD51C, BARD1, CDK12, CHEK1...

DRUG: Olaparib

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of O...

This phase II trial tests the safety of positron emission tomography (PET) guided stereotactic body radiation therapy (SBRT) and how well it works to treat non-small cell lung cancer (NSCLC), melanoma, and renal cell carcinoma (RCC) that has up to 5 ...

PROCEDURE: Biospecimen Collection

PROCEDURE: Computed Tomography

PROCEDURE: Positron Emission Tomography

OTHER: Questionnaire Administration

RADIATION: Stereotactic Body Radiation Therapy

Isatuximab in Patients With Monoclonal Gammopathy of Renal Significance

The purpose of this study is to see whether Isatuximab can help improve kidney function of participants with MGRS. Isatuximab is approved by the Food and Drug Administration (FDA) for the treatment of adult patients with multiple myeloma, but it is n...

DRUG: Isatuximab

Effect of Montelukast on Kidney and Vascular Function in Type 1 Diabetes

Kidney disease is a common problem among people with type 1 diabetes and can lead to disability, dialysis, and early death. Inflammation plays a key role in the development of kidney disease in type 1 diabetes and targeting leukotrienes, inflammatory...

DRUG: Montelukast

OTHER: Placebo

A Study of MK-8527 in Participants With Moderate and Severe Renal Impairment (MK-8527-008)

The goal of this study is to evaluate the effect of moderate and severe renal impairment (RI) on the pharmacokinetics (PK), safety, and tolerability of MK-8527. There will be no hypothesis testing in the study.

DRUG: MK-8527

Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

A prospective, single-arm, multi-center post-market surveillance study of the BD® WavelinQ™ EndoAVF System for the Creation of Arteriovenous (AV) Fistula in Patients Requiring Dialysis.

DEVICE: EndoAVF Creation

A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

The goal of the Phase 1 portion is to identify the maximum tolerated dose (MTD) and/or the recommended doses for expansion (RDEs) of NKT2152. The Phase 2 portion will evaluate the efficacy of NKT2152 in ccRCC.

DRUG: Oral NKT2152

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Pati...

This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell ca...

BIOLOGICAL: Avelumab

DRUG: Axitinib

DRUG: Cabozantinib

BIOLOGICAL: Ipilimumab

DRUG: Lenvatinib

BIOLOGICAL: Nivolumab

BIOLOGICAL: Pembrolizumab

RADIATION: Stereotactic Ablative Radiotherapy

Exercise Study Testing Enhanced Energetics of Mitochondria Video Integrated Delivery of Activity Tra...

Skeletal muscle dysfunction (sarcopenia) is an under-recognized target organ complication of CKD with substantial adverse clinical consequences of disability, hospitalization, and death. Sarcopenia in this proposal is defined by impaired metabolism a...

BEHAVIORAL: Combined Aerobic and Resistance Exercise via videoconferencing

EffCaMgCit to Prevent Mineral Metabolism and Renal Complications of Chronic PPI Therapy

Proton pump inhibitors (PPIs) are widely used for the control of gastric ulcer-gastritis, erosive esophagitis (gastroesophageal reflux disease), peptic ulcer disease (duodenal ulcer), and heartburn. Despite their efficacy, their use has been implicat...

DRUG: EffCaMgCit

OTHER: Placebo

Oral Iron in Children With Chronic Kidney Disease

This is a pilot clinical trial of oral iron therapy in children with chronic kidney disease (CKD) and mild anemia. Eligible children will be randomized into a standard of care (iron sulfate) arm vs. no iron therapy arm for 3 months. The outcomes will...

DRUG: Ferrous Sulfate

NAD Augmentation in Diabetes Kidney Disease

A phase 2a trial randomized, double-blind, placebo-controlled, parallel group trial to determine whether NMN administration improves DKD, as indicated by a significantly greater reduction in UACR compared with placebo administration. Eligible partici...

DRUG: Investigational Product - MIB 626

DRUG: Placebo

One-month Latent Tuberculosis Treatment for Renal Transplant Candidates

This is a prospective, single-center, single-arm, open-label study investigating the safety, compliance and pharmacokinetics of 1-month treatment of Isoniazid, Rifapentine and Vitamin B6 in renal transplant candidates.

DRUG: 1 month Rifapentine, Isoniazid and Vitamin B6

A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label I...

The purpose of this study is to evaluate the long-term safety and tolerability, of open label iptacopan in primary IgA nephropathy participants who have completed either the CLNP023X2203 or CLNP023A2301 clinical trials. The open-label design of the c...

DRUG: LNP023

Study to Evaluate R3R01 in Patients With Alport Syndrome and Patients With Focal Segmental Glomerulo...

This is a Phase 2, Multi-center, Open-Label Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of R3R01 in Alport Syndrome Patients with Uncontrolled Proteinuria on ACE/ARB Inhibition and in Patients with Primary Steroid-Resistant Fo...

DRUG: R3R01

Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Malignancies

This study is a Phase I/II, multicenter, first-in-human, open-label dose-escalation study of BT8009 given as a single agent and in combination with pembrolizumab in participants with advanced solid tumors associated with Nectin-4 expression or in par...

DRUG: BT8009

DRUG: Pembrolizumab

Spironolactone in CKD Enabled by Chlorthalidone: PILOT

Highly prevalent among patients with chronic kidney disease (CKD) and poorly controlled blood pressure (BP), is a modifiable risk factor to abrogate both kidney failure progression and cardiovascular (CV) disease. Spironolactone (SPL), a mineralocort...

DRUG: Spironolactone

DRUG: Chlorthalidone

DRUG: Placebo

Enhanced Recovery After Surgery in Kidney Transplant Donors

Enhanced recovery after surgery (ERAS) pathways are designed to optimize perioperative management, improving patient outcomes and satisfaction through multimodal techniques. Living kidney transplant donors are typically healthy individuals who underg...

PROCEDURE: multimodal pain management

OTHER: goal directed fluid management

OTHER: preoperative carbohydrate loading

PROCEDURE: Donor nephrectomy

PROCEDURE: regional anesthesia

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Sele...

The purpose of this study is to characterize the safety and tolerability of KFA115 and KFA115 in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or recommended dose.

DRUG: KFA115

DRUG: pembrolizumab

A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumor...

Phase 1 (Dose Escalation) of this study will assess the safety, tolerability, dose-limiting toxicity (DLT), and will determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of EU101 in participants with advanced solid tumors. P...

DRUG: EU101

AMPK-activation by Metformin in FSGS: AMP-FSGS

The primary objective of this study is to determine whether extended-release MF (in addition to standard of care (S-o-C)) is superior to placebo in reducing podocyte injury and promoting podocyte survival by 6-months in Focal Segmental Glomeruloscler...

DRUG: Metformin + Standard of Care

OTHER: Placebo + Standard of Care

Study to Evaluate the Safety and Tolerability of Ferric Citrate in Children With Hyperphosphatemia R...

This study will be conducted to assess the safety and tolerability of ferric citrate in pediatric participants with hyperphosphatemia related to chronic kidney disease (CKD).

DRUG: ferric citrate

Renal Anhydramnios Fetal Therapy

Early pregnancy renal anhydramnios or EPRA is a condition where a pregnant woman does not have any amniotic fluid around her fetus because of a problem with the fetus's kidneys. This condition is thought to be fatal once the fetus is born because of ...

PROCEDURE: Serial amnioinfusions with isotonic fluid

DEVICE: Spinal needle

DRUG: Isotonic fluid

A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease

Primary Objectives * To assess the safety and tolerability of RGLS8429 * To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives * To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) * To characterize ...

DRUG: RGLS8429

DRUG: Placebo

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells fo...

GENETIC: CARE T cells

DRUG: Cytoxan

DRUG: Fludara

Rollover Extension Clinical Trial To Evaluate The Long-Term Safety And Efficacy Of KT-301 (Formerly ...

This is an Open-Label Rollover Extension Clinical Trial to Evaluate the Long-Term Safety and Efficacy of KT-301 (formerly US-APR2020) in Subjects With CKD IV Who Completed the US-APR2020-01 Study

DRUG: KT-301 (formerly US-APR2020)

Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study of ALXN2050 (120 and 180 milligrams \[mg\]) in addition to background therapy consistent with the standard of care in adult participants (≥ 18 to ≤ 75 years of age) wi...

DRUG: ALXN2050

DRUG: Placebo

Renal Allograft Tolerance Through Mixed Chimerism - SMC/MGH

The goal is to investigate the safety of the conditioning regimen, and its ability to induce donor/recipient lymphohematopoietic chimerism without Chimerism Transition Syndrome (CTS), which may result in donor-specific unresponsiveness (tolerance) to...

DRUG: Rituximab, Fludarabine, Cyclophosphamide, Thymic irradiation and Siplizumab

PROCEDURE: Combined bone marrow and kidney transplant

Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced...

This is a Phase 1, open-label, dose escalation and expansion study of MT-8421 (an Engineered Toxin Body (ETB)) as monotherapy and in combination with nivolumab in patients with selected advanced solid cancer types. MT-8421 is an investigational drug ...

DRUG: MT-8421

DRUG: Nivolumab

Inspiratory Muscle Strength Training in Chronic Kidney Disease

More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control \<130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise com...

DEVICE: IMST

DEVICE: Sham Training

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.

DRUG: MDX2001

Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers Afte...

This phase Ib/II trial studies the side effects and best dose of plinabulin in combination with radiation therapy and immunotherapy in patients with select cancers that have spread to other places in the body (advanced) after progression on PD-1 or P...

BIOLOGICAL: Atezolizumab

DRUG: Avelumab

BIOLOGICAL: Durvalumab

BIOLOGICAL: Nivolumab

BIOLOGICAL: Pembrolizumab

DRUG: Plinabulin

RADIATION: Radiation Therapy

A Study With Imlifidase in Anti-GBM Disease

An open-label, controlled, randomised, multi-centre Phase 3 trial evaluating renal function in patients with severe anti-GBM disease comparing imlifidase and standard of care (SoC) with SoC alone. All patients will remain in the trial for 24 months.

DRUG: Imlifidase

PROCEDURE: Plasma exchange (PLEX)

DRUG: Cyclophosphamide (CYC)

DRUG: Glucocorticoids

A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes L...

This study will look if CagriSema can lower kidney damage in people with chronic kidney disease (CKD), type 2 diabetes (T2D) and overweight or obesity. CagriSema is a new investigational medicine. CagriSema cannot yet be prescribed by doctors. The st...

DRUG: Cagrilintide

DRUG: Semaglutide

DRUG: Placebo

A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Dis...

We are doing this study to learn more about how tirzepatide may help fight chronic kidney disease in people with obesity with or without type 2 diabetes (T2D). The study will last about 56 weeks and include up to 12 visits.

DRUG: Tirzepatide

DRUG: Placebo

Study of PULSAR-ICI +/- IMSA101 in Patients With Oligometastatic NSCLC and RCC

Phase 2, open-label, multicenter, randomized study comparing the safety and efficacy of personalized ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) combined with immune checkpoint inhibitor (ICI) immunotherapy (PULSAR-ICI) + IMSA101 a...

DRUG: IMSA101

DRUG: Immune checkpoint inhibitor

RADIATION: PULSAR

Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to St...

This phase III trial compares the effect of adding whole brain radiotherapy with hippocampal avoidance and memantine to stereotactic radiosurgery versus stereotactic radiosurgery alone in treating patients with cancer that has spread to the brain and...

DRUG: Memantine

OTHER: Quality-of-Life Assessment

OTHER: Questionnaire Administration

RADIATION: Stereotactic Radiosurgery

RADIATION: Whole-Brain Radiotherapy

Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access...

The purpose of this study is to compare two variations of the mini-PCNL procedure using either a vacuum-assisted sheath or standard sheath which are both used for the surgical treatment of kidney stones. Both procedure types are commonly used in the ...

DEVICE: vacuum assisted sheath

DEVICE: passive suction via conventional sheath

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell...

A Phase II Study of Nivolumab with Ipilimumab and Cabozantinib in Patients with Untreated Renal Cell Carcinoma Brain Metastases

DRUG: Nivolumab

DRUG: Ipilimumab

DRUG: Cabozantinib

A Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhoo...

This open-label, randomized multicenter study is to assess the efficacy, safety, and pharmacokinetics (PK)/pharmacodynamics (PD) of obinutuzumab compared with mycophenolate mofetil (MMF) in children and young adults (aged \>= 2-25 years) with frequen...

DRUG: Obinutuzumab

DRUG: MMF

DRUG: Prednisone

DRUG: Methylprednisolone

DRUG: Acetaminophen/ Paracetamol

DRUG: Diphenhydramine Hydrochloride

Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomeruloscleros...

Liposorber® LA-15 System is a blood purification therapy that selectively removes malignant lipoproteins including low density lipoprotein from circulating blood flow and rapidly reduces the plasma cholesterol level. The system was originally develop...

DEVICE: LIPOSORBER® LA-15 System

The Arteriovenous Vascular (AV) ACCESS Trial

This study is to prospectively compare the effectiveness and safety of the two types of arteriovenous access placement (fistula or graft) in older adults with end stage kidney disease and multiple chronic conditions

DEVICE: AV graft

PROCEDURE: surgical intervention for creation of a fistula

Calcitriol Monotherapy for X-Linked Hypophosphatemia

Children and adults with XLH recruited will be treated with calcitriol alone (without phosphate supplementation) for one year, during which the calcitriol dose will be escalated during the first 3 months of therapy. The investigators hypothesize that...

DRUG: Calcitriol

A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors

This clinical trial will evaluate raludotatug deruxtecan (R-DXd; DS-6000a) in participants with advanced renal cell carcinoma (RCC) and ovarian cancer (OVC). The main goals of this study will be to investigate the recommended dose of R-DXd that can b...

DRUG: DS-6000a

Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syn...

This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI

DRUG: R2R01

DRUG: Terlipressin

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carc...

The goal of the Lead-in phase of the study is to evaluate the safety, efficacy, pharmacokinetics (PK) and determine recommended dose for expansion (RDE) of NKT2152 in combination with palbociclib (Doublet) and with palbociclib and sasanlimab (Triplet...

DRUG: NKT2152

DRUG: palbociclib

OTHER: sasanlimab

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid ...

This is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody, as single agent and in combination with pembrolizumab in participants with advanc...

DRUG: ONC-392

DRUG: Pembrolizumab

DRUG: Docetaxel

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Loca...

This is a Phase 1/2, open-label, non-randomized, 4-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX 106 administered as a single agent or in combination with the ...

DRUG: INBRX-106 - Hexavalent OX40 agonist antibody

DRUG: pembrolizumab 200 mg

DRUG: pembrolizumab 400 mg

DRUG: Carboplatin AUC-5

DRUG: Carboplatin AUC-6

DRUG: Pemetrexed 500 mg/m2

DRUG: Cisplatin 75mg/m2

DRUG: Paclitaxel 200mg/m2

DRUG: Nab paclitaxel 100mg/m2

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplastic...

The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.

BEHAVIORAL: Home-based walking exercise

OTHER: Attention control

HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy

The purpose of this study is to determine whether the use of lower doses of busulfan and the elimination of cyclosporine will further reduce transplant-related side effects for patients with Fanconi Anemia (FA). Patients will undergo a transplant uti...

DRUG: Busulfan

DRUG: Cyclophosphamide

DRUG: Fludarabine

DRUG: rabbit ATG

DRUG: G-CSF

BIOLOGICAL: Peripheral blood stem cell

Effect of Empagliflozin on Podocyte Specific Proteins in African American Veterans With NDKD

Primary Objective:To study podocyte specific injury markers in African American Veterans with non-diabetic kidney disease(NDKD), on empagliflozin therapy. Primary Endpoint: Assess the effect of Empagliflozin on podocyte-specific proteins in exosomes...

DRUG: Empagliflozin 10 MG

DRUG: Placebo

NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therap...

The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.

DRUG: NBTXR3

RADIATION: SABR

DRUG: Nivolumab

DRUG: Pembrolizumab

A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Mono...

The purpose of this study is to find out whether cyclophosphamide, bortezomib, dexamethasone (CyBorD) with daratumumab SC is a safe treatment combination for MGRS-associated kidney disease including cast nephropathy associated with multiple myeloma. ...

DRUG: Cyclophosphamide

DRUG: Bortezomib

DRUG: Dexamethasone

DRUG: Daratumumab

NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospita...

The goal of this pilot, randomized, single-blind clinical trial is to estimate the effect size of a high and low mean arterial pressure (MAP)-target algorithm among cirrhosis patients hospitalized with acute kidney injury. The main aims to answer are...

DRUG: MAP-Target Algorithm

Pentoxifylline in Diabetic Kidney Disease

Pentoxifylline (PTX) is a medication that has been on the market since 1984 for use in disease in the blood vessels of the legs. There is some preliminary information that it may protect the kidneys from damage due to diabetes and other diseases. "Pe...

DRUG: Pentoxifylline

DRUG: Placebo

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not res...

DRUG: Vorinostat

High Dose IL-2 in Combination With Anti-PD-1 to Overcome Anti-PD-1 Resistance in Metastatic Melanoma...

The primary objective of this single arm phase 2 trial is to assess the response rate \[complete response (CR) + partial response (PR)\] of combined nivolumab and HD IL-2 in subjects with metastatic melanoma and renal cell carcinoma. Response will be...

DRUG: IL-2 and Nivolumab

Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome ...

The purpose of this Phase 3 study is to determine whether iptacopan (LNP023) is efficacious and safe for the treatment of aHUS in adult patients who are treatment naive to complement inhibitor therapy.

DRUG: Iptacopan

A Study to See if Tolvaptan Can Delay Dialysis in Infants and Children Who at Enrollment Are 28 Days...

The primary objective of this study is to evaluate the effect of tolvaptan on the need for renal replacement therapy in pediatric subjects with autosomal recessive polycystic kidney disease (ARPKD)

DRUG: Tolvaptan (OPC-41061)

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unr...

This phase II trial tests the combination of nivolumab and ipilimumab with sirolimus and prednisone for the treatment of skin (cutaneous) cancer that cannot be removed by surgery (unresectable) or that has spread from where it first started to other ...

PROCEDURE: Biopsy

PROCEDURE: Biospecimen Collection

PROCEDURE: Computed Tomography

BIOLOGICAL: Ipilimumab

PROCEDURE: Kidney Biopsy

PROCEDURE: Magnetic Resonance Imaging

BIOLOGICAL: Nivolumab

DRUG: Prednisone

DRUG: Sirolimus

PRO1160 for Advanced Solid and Liquid Tumors (PRO1160-001)

Brief Summary: This study will test the safety, including side effects, and determine the characteristics of a drug called PRO1160 in participants with solid tumors. Participants will have solid tumor or liquid cancer that has spread through the bo...

DRUG: PRO1160

Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis

This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD). The primary objectives of this pilot trial are to determine the ...

DRUG: Cephalexin

DRUG: Cephalexin or placebo

Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal...

This is a multicenter, randomized (2:1), open-label, controlled Phase 3 trial of XL092 in combination with nivolumab versus sunitinib in subjects with unresectable, locally advanced or metastatic nccRCC who have not received prior systemic anticancer...

DRUG: XL092

DRUG: Nivolumab

DRUG: Sunitinib Malate

A Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid Tum...

This is a phase I, First-in-Human (FIH), open-label study to evaluate the safety, tolerability, pharmacokinetic (PK) profile, and preliminary efficacy of AB248 as monotherapy OR in combination with pembrolizumab in adult participants with locally adv...

BIOLOGICAL: AB248

BIOLOGICAL: pembrolizumab

Safety & Efficacy of DCR-PHXC in Patients With PH1/2 and ESRD

The aim of this study is to evaluate DCR-PHXC in participants with PH1 or PH2 and severe renal impairment, with or without dialysis.

DRUG: DCR-PHXC

Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in ...

Study of NGM831 as Monotherapy and in Combination with Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

DRUG: NGM831

DRUG: NGM831 plus pembrolizumab (KEYTRUDA®)

DRUG: NGM831 and NGM438 plus pembrolizumab (KEYTRUDA®)

A Study of Adjuvant V940 and Pembrolizumab in Renal Cell Carcinoma (V940-004)

The primary objective of the study is to compare V940 plus pembrolizumab to placebo plus pembrolizumab with respect to disease-free survival (DFS) as assessed by the investigator. The primary hypothesis is that V940 plus pembrolizumab is superior to ...

BIOLOGICAL: V940

BIOLOGICAL: Pembrolizumab

BIOLOGICAL: Placebo

Safety and Efficacy of Two Year of RAAS Alone or in Combination With Spironolactone Therapy

NephroNet proposes to examine whether combining Spironolactone with maximal RAAS blockade will further reduce urinary protein at one year and whether prolonged therapy (24 months) is able to slow the decline in GFR. Because of combination MRA and RAA...

DRUG: Renin-Angiotensin (RAAS) alone

DRUG: Renin-Angiotensin (RAAS) blockers in combination with Spironolactone

A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary...

The main objective of this study is to evaluate the safety, efficacy and pharmacokinetics of paricalcitol oral solution in pediatric participants of ages 0 to 9 years with SHPT associated with stage 5 CKD receiving Peritoneal Dialysis (PD) or Hemodia...

DRUG: Paricalcitol

SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

This is a prospective, randomized, multi-center clinical trial for chronic kidney disease (CKD) patients referred for creation of a new arteriovenous fistula (AVF) in order to assess the safety and effectiveness of SelfWrap, a bioabsorbable perivascu...

DEVICE: SelfWrap Bioabsorbable Perivascular Wrap

PROCEDURE: Untreated AVF Control

Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab

The purpose of this research study is to test the safety and effectiveness of Seleno-L Methionine (SLM) when combined with the standard dose and schedule of Axitinib and Pembrolizumab in patients who have locally advanced or metastatic clear cell ren...

DRUG: Selenomethionine (SLM)

DRUG: Axitinib

DRUG: Pembrolizumab

A Study to Investigate the Safety and Tolerability of Intravenous QEQ278 in Patients With Advanced S...

To characterize safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of QEQ278 in adult patients with advanced/metastatic non-small cell lung cancer, esophageal squamous cell carcinoma, renal cell carcinoma, a...

BIOLOGICAL: QEQ278

Safety, Tolerability and Efficacy of AntiBKV as Treatment of BKV Infection in Kidney Transplant Reci...

The purpose of this study is to evaluate the safety, tolerability, and efficacy of AntiBKV in reducing BKV DNAemia and progression to biopsy-confirmed BKVAN in kidney transplant recipients. This study has an operationally seamless phase II/III design...

BIOLOGICAL: Anti-BK polyomavirus (AntiBKV)

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells...

GENETIC: CATCH T cells

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Lon...

Researchers are looking for a better way to treat people with chronic kidney disease (CKD), a progressive decrease in the kidneys' ability to work properly, and type 1 diabetes. In people with type 1 diabetes, the body does not make enough of a horm...

DRUG: Finerenone

OTHER: Placebo

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC R...

This phase II trial tests whether using genetic testing of tumor tissue to select the optimal treatment regimen works in treating patients with clear cell renal cell (kidney) cancer that has spread to other places in the body (advanced or metastatic)...

DRUG: Cabozantinib

BIOLOGICAL: Ipilimumab

BIOLOGICAL: Nivolumab

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer...

This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patients with rare genitourinary (GU) tumors that has spread from where it first started (primary site) to other places in the body. Cabo...

PROCEDURE: Bone Scan

DRUG: Cabozantinib S-malate

PROCEDURE: Computed Tomography

BIOLOGICAL: Ipilimumab

PROCEDURE: Magnetic Resonance Imaging

BIOLOGICAL: Nivolumab

PROCEDURE: Positron Emission Tomography

The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency

The primary purpose of Study INZ701-106 (The ENERGY 3 Study) is to assess the efficacy and safety of INZ-701 in children with ENPP1 Deficiency.

DRUG: INZ-701

DRUG: Control Arm (Conventional Therapy)

Narcotic-Free Percutaneous Nephrolithotomy

This is a randomized control trial comparing oral ketorolac and opioid medication for the use of post-operative analgesia.

DRUG: 5mg Oxycodone, Q6 PRN

DRUG: 10mg Ketorolac, Q6 PRN

A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pedi...

This study aims to evaluate the efficacy and safety of crovalimab in pediatric participants with aHUS.

DRUG: Crovalimab

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults Wi...

This is an open-label, multi-center, non-randomized Phase 1 study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeting CD19) in participants with active lupus nephritis (LN).

DRUG: NKX019

DRUG: Cyclophosphamide

CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition

The purpose of this study is to determine if the use of immunotherapy nivolumab and the targeted therapy cabozantinib prior to removal of the kidney, will increase the number subjects who are without any visible kidney cancer in their body at some po...

DRUG: Cabozantinib

DRUG: Nivolumab

PROCEDURE: Cytoreductive nephrectomy

Voclosporin in Adolescents With Lupus Nephritis

The purpose of this study is to assess the efficacy and safety of voclosporin compared to placebo in achieving renal response following 24 weeks of therapy in adolescents with active lupus nephritis (LN).

DRUG: Voclosporin

DRUG: Placebo Oral Capsule

CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome ...

DRUG: Metoprolol Succinate

DRUG: Carvedilol

A Trial to Find Out if REGN5678 is Safe and How Well it Works Alone or in Combination With Cemiplima...

The main purpose of this study is to determine the safety, tolerability (how your body reacts to the drug) and effectiveness (ability to treat your cancer) of REGN5678 alone, or in combination with cemiplimab. The study has 2 parts. The goal of Part...

DRUG: REGN5678

DRUG: Cemiplimab

AB-101 in Combination With B-Cell Depleting mAb in Patients Who Failed Treatment for Class III or IV...

AB-101 (also known as AlloNK) is an off-the shelf, allogeneic cell product made of "natural killer" cells, also called NK cells. White blood cells are part of the immune system and NK cells are a type of white blood cell that is known to enhance the ...

DRUG: AB-101

DRUG: Cyclophosphamide

DRUG: Fludarabine

DRUG: Rituximab

DRUG: Obinutuzumab

A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapaglifl...

The purpose of this study is to measure the efficacy and safety of baxdrostat/dapagliflozin in participants ≥ 18 years of age with CKD and HTN. This study consists of a screening, a 4-week dapagliflozin run-in period for participants naïve to SGLT2i ...

DRUG: Baxdrostat/dapagliflozin

DRUG: Dapagliflozin in combination with placebo

A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment

The purpose of this study is to evaluate the drug levels of mezigdomide in participants with renal impairment.

DRUG: Mezigdomide

Nivolumab and Ipilimumab With and Without Camu Camu for the Treatment of Patients With Metastatic Re...

This phase I trial tests the safety, side effects, and best dose of camu camu when used in combination with nivolumab and ipilimumab in treating patients with kidney cancer that has spread to other places in the body. A monoclonal antibody is a type ...

PROCEDURE: Biospecimen Collection

PROCEDURE: Bone Scan

PROCEDURE: Computed Tomography

BIOLOGICAL: Ipilimumab

PROCEDURE: Magnetic Resonance Imaging

DRUG: Myrciaria dubia Prebiotic Supplement

BIOLOGICAL: Nivolumab

Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

The primary objective of this study to evaluate the efficacy of ravulizumab compared with placebo to reduce proteinuria and slow the rate of eGFR decline in adult participants with IgAN who are at risk of disease progression.

DRUG: Ravulizumab

DRUG: Placebo

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