Discontinuation of Continuous Renal Replacement Therapy in Patients With Acute Kidney Injury: A Pilot Quasi-experimental Study (DC-CRRT)

Description

In this study, investigators are going to test whether a standardize approach to discontinuation of Continuous Renal Replacement Therapy (CRRT) using a set of criteria improves outcomes. These criteria are based on the best available evidence. In a systematic review, aside from urine output, there was no one factor that predicted successful weaning of RRT in patients with AKI. Urine output prior to discontinuation of RRT was the most commonly described and robust predictor. The pooled analysis found a sensitivity of 66.2% and specificity of 73.6% for urine output to predict successful RRT discontinuation. Patients with AKI on CRRT recruited during the first half of the study will be controls (usual process of care). After accrual, patients recruited for the second half will receive the intervention where discontinuation of CRRT will be guided by a set of criteria based on the patient's hemodynamic status and other factors.To the investigator's knowledge, no study has evaluated the impa

Trial Eligibility

Inclusion criteria: * Diagnosis of acute kidney injury * Being started on continuous renal replacement therapy Exclusion criteria: * Diagnosis of chronic kidney disease stage 5 or end-stage renal disease * Having received a kidney transplant * Moribund patients (who are expected to die within 1 day of CRRT initiation) * Presence of an intoxication requiring extracorporeal removal * RRT within the previous 1 month * Rapidly progressive glomerulonephritis

Study Info

Interventions

Locations Recruiting

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