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Effect of Plant-based Diet on Cardiometabolic and Inflammatory Parameters in Kidney Transplant Recipients


Description

The goal of this clinical trial is to evaluate cardiometabolic and inflammatory parameters in kidney transplant recipients after transitioning to a plant-based diet (PBD). The main aims of the study are as follows: * To test the feasibility of transiting renal allograft recipients who are \> 3 months post-transplant to a PBD * To study the effect of a PBD on cardiometabolic parameters in kidney transplant recipients * To assess the effect of a PBD on peripheral blood Th17/Treg ratio and systemic inflammation in kidney transplant recipients Participants will be asked to: * Complete a 2-week investigator-designed PBD transition program * Follow a PBD for a minimum of 16 weeks * Consent for blood draws, urine samples, and fecal samples along with physical exams * Complete intermittent food frequency questionnaires and quality of life questionnaires * Periodically meet with investigators and other study participants Researchers will compare baseline measurements with future measurement

Trial Eligibility

Inclusion Criteria: * \> 3 months post-kidney transplant * On style immunosuppressive medication * Without evidence of active infection/ inflammatory conditions * Estimated glomerular filtration rate \> 45ml/min/1.73 m\^2 * English speaking * Reliable internet access Exclusion Criteria: * Acute/ chronic allograft rejection * History of non-compliance * Advance heart failure * Liver disease * Pregnancy * Malignancy * Chronic Infection * Currently following a plant-based diet

Study Info

Organization

George Washington University


Primary Outcome

Th17/ Treg ratio


Outcome Timeframe Baseline, week 10, 18, 26

NCTID NCT06186843

Phases NA

Primary Purpose TREATMENT

Start Date 2024-02-29

Completion Date 2024-09-01

Enrollment Target 25

Interventions

BEHAVIORAL Plant-based diet

Locations Recruiting

Transplant Institute

United States, District of Columbia, Washington


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