Phase I Study of EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Description

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a EGFR-specific receptor (chimeric antigen receptor, or CAR) that will target and kill solid tumors that express EGFR and the selection-suicide marker EGFRt. EGFRt is a protein incorporated into the cell with our EGFR receptor which is used to identify the modified T cells and can be used as a tag that allows for elimination of the modified T cells if needed. On Arm A of the study, research participants will receive EGFR-specific CAR T cells only. On Arm B of the study, research participants will receive CAR T cells directed at EGFR and CD19, a marker on the surface of B lymphocytes, following the hypothesis that CD19+ B cells serving in their normal

Trial Eligibility

Inclusion Criteria: * First 2 subjects enrolled and treated in both Arm A and Arm B: age ≥ 15 and ≤ 30 years * Subsequent subjects: age ≥ 1 and ≤30years * Histologically diagnosed malignant, non-CNS solid tumor expressing EGFR * Evidence of refractory or recurrent disease * Able to tolerate apheresis or has apheresis product available for use in manufacturing * Life expectancy ≥ 8 weeks * Lansky or Karnofsky score ≥ 50 * Recovered from significant acute toxic effects of all prior chemotherapy, immunotherapy, and radiotherapy * If no apheresis product or T cell product is available,≥ 7 days post last chemotherapy/biologic therapy administration * If no apheresis product or T cell product is available,≥ 3 half lives or 30 days, whichever is shorter, post last dose of anti-tumor antibody therapy (including check point inhibitor) * Prior genetically modified cell therapy is allowed if not detectable at enrollment. * If no apheresis product or T cell product is available,≥ 6 weeks post last dose of myeloablative therapy and allogeneic or autologous stem cell transplant * Subjects who receive autologous stem cell infusion following non-myeloablative therapy are eligible once all other eligibility requirements are met * If no apheresis product or T cell product is available,≥ 7 days post last systemic corticosteroid therapy (physiologic replacement dosing is allowed) * If no apheresis product or T cell product is available, subjects with neuroblastoma must be ≥ 12 weeks from I131 MIBG therapy. * Adequate organ function * Adequate laboratory values * Patients of childbearing potential must agree to use highly effective contraception Exclusion Criteria: * Presence of active malignancy other than primary malignant solid tumor diagnosis * Current relevant CNS pathology * Presence of active GVHD, or receiving immunosuppressive therapy for treatment or prevention of GVHD within 4 weeks prior to enrollment * Presence of active severe infection * Presence of primary immunodeficiency syndrome * Receiving external beam radiation therapy at time of enrollment * Receiving any anti-cancer agents or chemotherapy * Pregnant or breastfeeding * Unwilling to provide consent/assent for participation in the study and 15 year follow up period * Presence of any condition that, in the opinion of the investigator, would prohibit the patient from undergoing treatment under this protocol

Study Info

Interventions

Locations Recruiting

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