Data related to the Phase 1 study development of briquilimab in combination with fludarabine and low-dose irradiation (Flu/TBI) in older adults (62 to 79 years) with AML, undergoing allogeneic hematopoietic cell transplant (HCT), has been presented by Jasper Therapeutics at the 2023 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR.
Briquilimab has shown it is a safe and well-tolerated conditioning agent for older patients (average age, 70 years) who are receiving an allogeneic hematopoietic cell transplantation, lower than expected rates of severe acute and chronic graft-vs-host disease and “durable remissions achieved in 8 of the first 12 AML patients treated at one-year follow up.”
Briquilimab (formerly known as JSP191) is a monoclonal antibody (a type of a protein that is created in a lab that can bind to certain antigens on the surface of a cancer cell) that inhibits the cell surface receptor, c-Kit (also known as CD117). “CD117 is the receptor for Stem Cell Factor on blood forming cells. CD117 binding to Stem Cell Factor is critical for survival and maintenance of blood forming stem cells. (NCT04429191).”
Blood stem cell transplants offer the only curative chance for overall survival (OS) in patients with AML. Thus, “The binding of briquilimab to CD117 blocks CD117 from binding to Stem Cell Factor on blood forming stem cells. In the absence of CD117/Stem Cell Factor binding, hematopoietic stem cells that are currently occupying the bone marrow niches in MDS/AML patients are depleted.”
This is a Phase 1a/b interventional study on the safety and tolerability of briquilimab combined with fludarabine and low-dose radiation.
Data related to the Phase 1 study development of briquilimab in combination with fludarabine and low-dose irradiation (Flu/TBI) in older adults (62 to 79 years) with AML, undergoing allogeneic hematopoietic cell transplant (HCT), has been presented by Jasper Therapeutics at the 2023 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR.
Briquilimab has shown it is a safe and well-tolerated conditioning agent for older patients (average age, 70 years) who are receiving an allogeneic hematopoietic cell transplantation, lower than expected rates of severe acute and chronic graft-vs-host disease and “durable remissions achieved in 8 of the first 12 AML patients treated at one-year follow up.”
Briquilimab (formerly known as JSP191) is a monoclonal antibody (a type of a protein that is created in a lab that can bind to certain antigens on the surface of a cancer cell) that inhibits the cell surface receptor, c-Kit (also known as CD117). “CD117 is the receptor for Stem Cell Factor on blood forming cells. CD117 binding to Stem Cell Factor is critical for survival and maintenance of blood forming stem cells. (NCT04429191).”
Blood stem cell transplants offer the only curative chance for overall survival (OS) in patients with AML. Thus, “The binding of briquilimab to CD117 blocks CD117 from binding to Stem Cell Factor on blood forming stem cells. In the absence of CD117/Stem Cell Factor binding, hematopoietic stem cells that are currently occupying the bone marrow niches in MDS/AML patients are depleted.”
This is a Phase 1a/b interventional study on the safety and tolerability of briquilimab combined with fludarabine and low-dose radiation.
about the author
Lisa Foster
Lisa Foster is a mom of 3 daughters, a puzzle lover, writer and HealthTree advocate. She believes in the mission of the foundation and the team that builds it forward. She calls Houston, Texas home.