Dr. Omer Jamy is an AML expert and bone marrow transplant physician at the University of Alabama at Birmingham. At the 2023 ASCO conference, he shared details with HealthTree about his open phase 3 study looking at a new vaccine therapy that targets the Wilms tumor 1 (WT1) protein, the top immunotherapy target in cancer treatment.
WT1 has emerged as an encouraging vaccine target in AML due to its overexpression in AML cells. Dr. Jamy is involved in a randomized phase 3 study for patients with AML in second remission or beyond that randomizes patients to receive either a vaccine called galinpepimut-S (GPS) or the physician's choice of the best available therapy. GPS is a vaccine that works againsts WT1, a protein expressed on AML cells. There is early data from phase 2 studies and pre-clinical data that show this vaccine can be a therapy that keeps people in remission if they are unable to proceed to a stem cell transplant. Because there are not many standard of care treatment options available for patients who cannot undergo transplant, if successful, Dr. Jamy’s phase 3 study could fill the gap for this subset of patients. This study is currently enrolling and will enroll between 120 to 140 patients. The study is taking place at 50 centers with plans to open an additional 20 internationally.
Dr. Omer Jamy is an AML expert and bone marrow transplant physician at the University of Alabama at Birmingham. At the 2023 ASCO conference, he shared details with HealthTree about his open phase 3 study looking at a new vaccine therapy that targets the Wilms tumor 1 (WT1) protein, the top immunotherapy target in cancer treatment.
WT1 has emerged as an encouraging vaccine target in AML due to its overexpression in AML cells. Dr. Jamy is involved in a randomized phase 3 study for patients with AML in second remission or beyond that randomizes patients to receive either a vaccine called galinpepimut-S (GPS) or the physician's choice of the best available therapy. GPS is a vaccine that works againsts WT1, a protein expressed on AML cells. There is early data from phase 2 studies and pre-clinical data that show this vaccine can be a therapy that keeps people in remission if they are unable to proceed to a stem cell transplant. Because there are not many standard of care treatment options available for patients who cannot undergo transplant, if successful, Dr. Jamy’s phase 3 study could fill the gap for this subset of patients. This study is currently enrolling and will enroll between 120 to 140 patients. The study is taking place at 50 centers with plans to open an additional 20 internationally.
about the author
Katie Braswell
Katie joined HealthTree as the Community Director for AML in 2021 and became HealthTree's Director of Education in 2023. Katie is a registered dietitian who is passionate about health literacy and patient empowerment. She loves to cook, travel and spend time with her newborn son, husband and dog.
Subscribe to the weekly newsletter for news, stories, clinical trial updates, and helpful resources and events with cancer experts.