How it Works

Treanda is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Treanda is classified as an "alkylating agent."

Treanda causes intra- and inter-strand crosslinks between DNA bases resulting in cell death.

How it’s Administered

TREANDA is available in two formulations, a solution (TREANDA Injection) for IV injection and a lyophilized powder (TREANDA for Injection).

The two different administrations have different concentrations of bendamustine hydrochloride. The concentration of bendamustine hydrochloride in the solution is 90 mg/mL, and the concentration of bendamustine hydrochloride in the reconstituted solution of lyophilized powder is 5 mg/mL. Do not mix or combine the two formulations.

Who Should Take Treanda

Treanda is currently approved for:

• Chronic Lymphocytic Leukemia (CLL) TREANDA® is indicated to treat patients with chronic lymphocytic leukemia. Efficacy relative to first-line therapies other than chlorambucil has not been established
• Non-Hodgkin’s Lymphoma (NHL)TREANDA for Injection is indicated to treat patients with indolent B-cell non-Hodgkin’s lymphoma that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen
• Studies have proven the safety and efficacy of bendamustine administered alone or in combination with new drugs in both upfront and relapse/refractory settings of MM patients, including those with renal impairment. Moreover, bendamustine has been successfully used as conditioning for autologous stem-cell transplantation. Finally, the use of bendamustine does not compromise peripheral blood stem-cell collection

Who Shouldn’t Take Treanda

• Patients who are allergic to bendamustine or mannitol
• Pregnant women
• Children under 18

The Most Common Side Effects of Taking Treanda Include: 

• Lymphopenia
• Anemia
•  Leukopenia
• Thrombocytopenia
• Neutropenia

Commonly Used With 

• Pomalidomide
• Dexamethasone

Commonly Being Tested With

• Immunomodulators (IMiDs): Pomalidomide
• Corticosteroids: Dexamethasone
• Alkylating Agents: Melphalan
• Proteasome Inhibitors: Carfilzomib

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