Tell your musician friends to donate a song today on Songs For Life to help raise funds for multiple myeloma research! Dr. Sarah Holstein, MD, PhD, Roswell Park Cancer Institute Interview Date: September 19, 2014
Dr. Sarah Holstein describes a very exciting new immunotherapy that will open in a Phase I/II clinical trial shortly. This new drug called ALT-803 by Altor Bioscience was listed as one of the most exciting immunotherapy choices according to the NCI. In experiments in mice, it changed the immune system to kill myeloma cells and then trained the immune system with a memory to continue attacking it, even when more myeloma cells were injected. Dr. Holstein shares the details of how this new therapy works. She also discusses her research to "choke" myeloma cells with their own product by leveraging the secretory nature of myeloma (the production of the M-spike). Additionally, she shares three strategies to overcome bortezomib resistance - 1) using HDAC inhibitors, 2)Using new heat shock proteins and 3) Manipulating the bone marrow microenvironment. There is much to learn in this excellent show. The live mPatient Myeloma Radio podcast with Dr. Sarah Holstein, MD, PhD,
Dr. Holstein is a physician-scientist who specializes in the treatment of multiple myeloma and related plasma cell dyscrasias. Prior to joining the faculty at UNMC, Dr. Holstein served as a myeloma specialist at the Roswell Park Cancer Institute and the University of Iowa. Her laboratory is focused on gaining a better understanding of the pathophysiology of multiple myeloma and the development of novel therapeutic agents for multiple myeloma. Her laboratory research has received funding from such sources as the National Institutes of Health, the American Society of Hematology, and the PhRMA Foundation. Dr. Holstein is an active clinical investigator, and has been involved in clinical trials for patients with newly diagnosed myeloma, with relapsed/refractory disease, as well as in the post-transplant maintenance setting. She has written numerous peer-reviewed research articles as well as review articles and book chapters. She is a member of the Alliance Multiple Myeloma Committee and the NCCN Multiple Myeloma Panel.
Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of the HealthTree Foundation.
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