HealthTree Logo
search more_vert
App Logo
close
person Sign In / Create Account
Dr. Rodger Tiedemann discusses why myeloma persistently returns and his work to strike at the root of the disease by targeting earlier stage progenitor cells
Dr. Rodger Tiedemann discusses why myeloma persistently returns and his work to strike at the root of the disease by targeting earlier stage progenitor cells image
HealthTree Podcast for Multiple Myeloma
event Oct 22, 2013 / 11:00AM - 12:00PM MDT

Event Description

Dr. Rodger Tiedemann, PhD, ChB, MB, Ontario Cancer Institute, Princess Margaret Hospital, University of Toronto Interview date: October 18, 2013 

Dr. Rodger Tiedemann describes why proteasome inhibitors are useful to treat myeloma but will never be a cure for myeloma. He shares how they are more like a persnickety goat, eating the weeds and flowers of the myeloma, but never touching the root. He explains his findings that genes IRE1 and XBP1 cause stress in the plasma cells, which create the M-spike. Interestingly, the earlier progenitor cells don't have this XBP1 gene and are less sensitive to this class of drugs. He shares how proteasome inhibitor resistance can be either resistance from the get-go before any treatment is given or resistance that is acquired over the life of treatment.  He takes us back to 10th grade biology and explains the hierarchy of cell production: stem cells regenerate both new stem cells and also multiple layers of progenitor cells, which eventually become plasma cells. He describes his next step to screen drugs to see which ones affect the earlier progenitor cells before they turn into plasma cells to hit both early and later stage myeloma cells. He describes the 8 sub-types of myeloma and describes his search for genes that affect myeloma growth - how he has used RNA screening of 8,000 possible genes to find a short-list of messenger genes that are signaling myeloma cell growth. He shares an open clinical trial that targets the signaling shutdown of one of these genes (XPO1), a drug that essentially "kills the messenger." He also describes an additional study of his trying to accomplish two things at once: using busulphan and melphalan together before transplant to improve impact on remission and at the same time looking at the impact on progenitor cells. He explains how he is able to overcome past toxicity issues by adjusting the dose of busulphan for patients individually. The live mPatient Radio podcast with Dr. Rodger Tiedemann

Schedule & Agenda

person
Discussion
11:00AM
Dr. Rodger Tiedemann & Jenny Ahlstrom

Speakers & Moderators

The panelist Jennifer Ahlstrom
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of the HealthTree Foundation.

Read Bio

Have Any Questions?

Thank you for your interest in the event. If you have any questions, we would love to help!

Feel free to give us a call or send us a message below.

support

Get In Touch With Us

phone

+1 800 709 1113

email

Support@healthtree.org

Get the latest thought leadership on Myeloma delivered straight to your inbox.

Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life with Myeloma stories, Myeloma clinical trials, Myeloma 101 articles and events with Myeloma experts.

Thanks to our HealthTree Community for Myeloma Sponsors:

Janssen Oncology
Adaptive Biotechnologies
Amgen Oncology
Abbvie
Genentech
Bristol Myers Squibb

Follow Us

facebook instagram twitter youtube