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Dysregulation of Glutamine Utilization in the Pathogenesis of Multiple Myeloma


PRIMARY OBJECTIVE: I. Compare the glutamine anaplerosis activity in bone marrow clonal plasma cells (cPCs) between patients with MGUS and MM using an in vivo and an ex vivo approach. SECONDARY OBJECTIVES: I. Compare the tricarboxylic acid (TCA) isotopomer enrichment in the bone marrow plasma obtained from patients with MGUS and MM with the in vivo approach. II. Determine the peripheral blood enrichment of 13C in the TCA cycle intermediates from patients with MGUS and MM with the in vivo approach. OUTLINE: Patients are assigned to 1 of 2 groups. GROUP I (EX-VIVO): After an overnight fast of 6 hours, patients undergo collection of blood samples. GROUP II (IN VIVO): After an overnight fast of 6 hours, patients receive 13-carbon labeled glutamine or 13-carbon-labeled glucose intravenously (IV) over 90 minutes. Patients also undergo collection of blood and bone marrow aspirate samples. After completion of study, patient are followed up for 4 weeks.

Trial Eligibility

Inclusion Criteria: * At least 18 years of age * International Myeloma Working Group (IMWG) criteria for the diagnosis of either MGUS or MM Exclusion Criteria: * Unable to provide consent * Eastern Cooperative Oncology Group (ECOG) performance status (PS) \> 3 * Hemoglobin \< 8 g/dL * Women who are pregnant * Prior history of adverse events with conscious sedation

Study Info


Mayo Clinic

Primary Outcome

Percent enrichment of 13-Carbon in the tricarboxylic acid (TCA) cycle intermediates within bone marrow plasma cells from patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma

Outcome Timeframe Up to 1 day

NCTID NCT03119883

Phases NA

Primary Purpose BASIC_SCIENCE

Start Date 2017-06-02

Completion Date 2024-06-30

Enrollment Target 80


OTHER 5-Carbon C 13-labeled Glutamine

PROCEDURE Biospecimen Collection

PROCEDURE Biospecimen Collection

OTHER Uniformly-labeled [13C]glucose

Locations Recruiting

Mayo Clinic in Rochester

United States, Minnesota, Rochester

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