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Know Your Options Against Infections - Immunoglobulin Infusions (IVIG) for CLL Patients
Posted: Aug 12, 2024
Know Your Options Against Infections - Immunoglobulin Infusions (IVIG) for CLL Patients  image

Why Am I at High Risk for Infections? 

Chronic lymphocytic leukemia (CLL) patients are at risk of increased infections. CLL is the result of an overproduction of B-cells which are white blood cells that make antibodies. This overproduction is due to the abnormal mutations in B-cells making them unable to fight infections and occupying space in the bone marrow that could lead to low production of healthy white blood cells that are effective against infections.

Normally, if a B-cell comes across a harmful substance, cancer cell or microorganism (all of them are also known as pathogens), it produces antibodies that activate other immune cells and create an inflammatory response, this will make sure that whatever substance is detected, and effectively eliminated.  The B-cell will lock onto the pathogen ensuring it does not replicate and won’t infect other cells. 

Other treatments such as targeted therapies like venetoclax and BTK inhibitors, although a helpful step in the right direction to not kill many healthy cells along with cancer cells, can decrease or limit the growth of cancerous B-cells as well as healthy B-cells, debilitating the immune response as consequence. 

Because of these factors, it’s common in CLL patients to be more prone to getting sick from infections. Since they have a weakened immune system, it’s important to have supportive measures that ensure their good health. 

What Measures Can I Take if I Have a Weakened Immune System? 

  • Eat nutrient-dense foods to boost your immune system
  • Increase antioxidant rich foods to reduce oxidative stress 
  • Stay hydrated; you can have warm water, and it’s easier for your body to regulate the temperature when you ingest warm water instead of cold. 
  • Increase low-impact or mild exercise time, to maintain a good muscle mass percentage and boost your immune system and metabolism
  • Some health professionals may recommend additional medicines to prevent infections in the clinic. These medicines can include antivirals, antibiotics against bacteria, antifungals, and vaccines. Especially if a patient will undergo a treatment that will temporarily weaken the immune system. 
  • Vaccination is encouraged for all patients, even if they are not actively receiving treatment, it’s important that they stay up-to-date with vaccinations, especially the non-live versions

What is IVIG?

IVIG or intravenous immunoglobulin is a supportive measure that some doctors prescribe when a patient’s immunoglobulin levels are low. 

Immunoglobulins also known as antibodies are proteins that specifically recognize and bind to particular pathogens, such as bacteria or viruses, and help immune cells identify them to easily eliminate them. 

To find out if a patient has low immunoglobulin levels, a blood sample is required, that way, doctors can assess if a patient is eligible to receive an immunoglobulin infusion. 

Intravenous Immunoglobulin (IVIG) is a blood product prepared from the serum of multiple donors. It is mainly made of immunoglobulin G (IgG), and it provides a source of infection-fighting antibodies for CLL patients. These donor antibodies help prevent the risk of infections for CLL patients. 

What Should I Expect From an IVIG?  

The donor antibodies are administered intravenously (a needle into the vein). The infusion typically takes between 2-4 hours depending on the prescribed dose. Patients are monitored at the care facility during the infusion. But it’s also possible to receive the infusion at home. You can talk with your doctor about your infusion options. 

CLL patients may only need IVIG once a month if they are actively undergoing treatment, such as venetoclax or a BTK inhibitor. Patients not actively undergoing treatment, such as those in watch and wait or individuals who have just finished treatment, may not need IVIG, or if it is administered, it may be in less frequent doses. Your health professional will help determine the best dosing schedule based on individual patient needs. 

What are the Side Effects from IVIG? 

Most patients don’t have side effects from IVIG. Possible side effects may include temporary headache and flu-like symptoms of fever and chills (can last 24-48 hours after the infusion). To minimize these effects, healthcare providers might pre-medicate patients with antihistamines or acetaminophen. Slowing the rate of infusion can also help reduce side effects.

What IVIG Brands are Available? 

CLL patients will usually receive the IVIG brand Gammagard. Other brands of IVIG include Privigen and Octagam. Differences between the brands, include factors like the source of donors, the purification process, and the concentration. Patients may respond better to one brand over another.

IVIG Cost, Insurance Coverage, and Financial Support Resources

Insurance companies usually cover the cost of IVIG so long as it is medically necessary.

For patients covered by Medicare, Medicare will pay 80% of the IVIG cost. The other 20% must be covered by a supplemental plan or by the patient. Under Part B, only the medicine cost is covered. Supplies and infusion pumps are not covered (see below financial resources to help cover any cost gaps). 

IVIG can cost between $5,000 and $10,000 per treatment without insurance. However, many financial resources can help reduce or waive costs and get you the medical help you need. 

Several of these financial support programs include: 

  • Gammagard: Apply for financial assistance through the IVIG pharma company Takeda directly. 1-866-861-1750
  • If you are receiving home infusions, speak with the home infusion company via their website or talk to your infusion nurse and/or case manager 
  • NeedyMeds: Has an extensive database of patient assistance programs, state assistance, medicine discount programs, and free or low-cost medical care. They also help walk patients through the financial assistance process 
  • IVIG Copay Assistance from AmeriPharma 866-634-1046
  • The Assistance Fund: Helps patients and families facing high medical out-of-pocket costs by providing financial assistance for their copayments, coinsurance, deductibles, and other health-related expenses
  • Accessia Health: They specialize in health insurance premiums, pharmacy co-payment, and co-payment waiver assistance 
  • Partnership for Prescription Assistance: Connects pharma companies, healthcare providers, patient advocacy organizations, and community groups to help qualify patients who are uninsured or underinsured get free or nearly free medicines through a public or private program that is right for them
  • Patient Advocate Foundation: Provides medicine financial aid funds and copay assistance 
  • Good Days - Offers medicine financial assistance, premium assistance, and travel assistance
  • Healthwell Foundation: Helps patients cover the gap between what insurance does not cover related to copayments, deductibles, and health insurance premiums
  • RxAssist: Helps provide free or affordable medicines and co-pay assistance
  • RxHope: Helps with the financial assistance application process 
  • RxOutreach: A mail-order pharmacy for people with little to no health insurance coverage 
  • QuickRX IVIG Copay Assistance Program: Works with various organizations and manufacturer assistance programs to help make a patient’s medication affordable.

We want you to get the best treatments you can to help support your length and quality of life. Difficult side effects like increased risk of infection can be prevented with supportive measures like IVIG. Know your options and talk with your doctor about your immunoglobulin levels. If they are low, review the possibility of getting an IVIG prescription to prevent potentially severe infections. 

Accelerate the discovery of new treatment options by connecting records to HealthTree Cure Hub, an innovation that powers life-saving research!

If you are interested in participating in or finding a clinical trial, locating a CLL specialist, or staying informed about updates on CLL with our biweekly newsletter, you can create a free HealthTree Cure Hub account!



The author Jimena Vicencio

about the author
Jimena Vicencio

Jimena is an International Medical Graduate who is part of the HealthTree Writing team. She loves learning new things led by her curiosity, playing with her pets, and exercising in her free time.

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