The AVO study is reviewing if using a fixed treatment duration of acalabrutinib (calquence), venetoclax (venclexta), and obinutuzumab (gazyva) can help CLL/SLL patients achieve a timely and deep remission (partial or full decrease of cancer cells and signs/symptoms in the blood and bone marrow that lasts for several years).
Venetoclax (non-chemo BCL2 inhibitor) is effective at reducing the cancer cells for many CLL patients with or without high-risk features like del(17p)/TP53 mutation. The reason to combine venetoclax with the monoclonal antibody obinituzumab came from the need to extend the time of remission for patients with high-risk features. Without the addition of the monoclonal antibody, patients with high-risk features like del(17p)/TP53 mutation had shorter remission periods than those without. Venetoclax + obinutuzumab is administered over a 12-month treatment course for first-time treated CLL patients.
Acalabrutinib (non-chemo BTK inhibitor) is currently approved to treat CLL with or without obinutuzumab for first-time treatment. Acalabrutinib is approved to be taken by itself for previously treated CLL patients. The treatment combination showed effective results at reducing CLL signs/symptoms and the cells in the body for patients with and without high-risk features. Acalabrutinib is taken indefinitely until CLL cell resistance occurs or unable the patient is unable to tolerate the medication's side effects. The study did not have information related to uMRD for this treatment combination.
In combining these medicines together, the study’s goal was to achieve little to no cancer cells in the blood or bone marrow (uMRD) using a highly sensitive test of flow cytometry for CLL/SLL patients that had not received treatment before.
Updates from phase 2 of the study showed that the percentage of patients that achieved uMRD in the blood and bone marrow were very similar for patients with and without high-risk genetic features like del(17p)/TP53 mutation.
After administering acalabrutinib, obinutuzumab, and venetoclax for 16 cycles (each cycle was for 28 days), on day 1 of the 16th cycle, researchers took bone marrow samples of the patients. Those that had achieved uMRD stopped treatment. Patients that had only some but not a full reduction of CLL cancer cells in the bone marrow continued with 9 more cycles of treatment. The next bone marrow test was taken on day one of cycle 25.
Data showed a good safety profile with low-risk side effects that occurred in only 25% of the patient group (78% of those being headache, 76% fatigue, and 66% bruising). Following up at 35 months, side effects occurring in the blood included 37% of patients experiencing neutropenia at grade 3 or 4, and most patients experiencing thrombocytopenia and anemia but were able to be managed (see here for common solutions to CLL medicine side effects).
Side-by-side comparison data of all first-time treated CLL patients with and without del(17p)/TP53 mutation on VO (fixed duration treatment of 12 months then treatment stops), AO (A- continual therapy, O portion fixed duration), or AVO (fixed duration).
The AVO study shows promising data of a fixed duration therapy with high uMRD, high percentages of patients whose disease does not progress after treatment for multiple years, and a greater reduction of CLL signs/symptoms compared to other treatment combinations. The study is ongoing and continues to review the effectiveness of the AVO treatment combination. For more updates about CLL clinical trials, see here.
about the author
Megan Heaps
Megan joined HealthTree as a Community Coordinator for CLL in 2022. She is the daughter of a blood cancer patient and has found a passion for helping support patients and caregivers to advance research for their cure and improve their quality of life. In her spare time, she loves to be around family, sew, and cook.
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