Dr. Redner's research interest has been the molecular biology of leukemic transformation and myeloid differentiation. A major focus of his laboratory has been the mechanism underlying differentiation arrest in myeloid leukemia, investigating acute promyelocytic leukemia (APL) as a model system. His group first cloned the NPM-RAR translocation that characterizes the t(5;17) variant of APL, and we have had an active program studying the mechanism by which NPM-RAR generates the leukemic phenotype
UPMC Mario Lemieux Center for Blood Cancers: 5115 Centre Ave #4, Pittsburgh, PA 15232, USA
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