The Benefits of Exercise for Myeloproliferative Neoplasms (MPNs)

A recent clinical trial called MPN-FIT studied how a home-based exercise program could help people living with myeloproliferative neoplasms (MPN)s. This study looked at how physical activity can create positive changes in the body’s inflammatory markers.

Exercise prescription to staying active and avoiding lesions

The MPN-FIT trial followed 55 patients. One group started an exercise program immediately. The other "waitlist" group maintained their usual activity. 

The exercise group received a personalized 12-week plan designed by a kinesiologist. A kinesiologist is a health professional who uses knowledge in anatomy and movement to help people improve physical health and rehabilitation. The routine was manageable and took about 30 minutes to complete, two to three times per week. 

It focused on four key areas:

• Aerobics: Movements like military walks and jumping jacks to improve heart health.
• Resistance: Squats and push-ups to build strength.
• Balance: Specific routines to help prevent falls.
• Flexibility: Stretching targeting the back, legs, and shoulders.

The study measured LDH, an inflammation indicator to see if exercise could reduce inflammation

LDH can be used as a marker for how active the cancer cells are in the body. High levels can be linked to a higher symptom burden. The group who did regular exercise had a reduction in lactate dehydrogenase (LDH) levels. 

Researchers believe that regular exercise may help lower these levels by reducing inflammation and improving how the body uses oxygen. The study also noticed a reduction of several inflammatory proteins (cytokines) in the exercise group.

Sticking to an exercise routine is easier when it’s flexible and fun

People found the program easy to follow from home using digital tools or paper journals. About 92% of the participants said they intended to keep exercising even after the study ended. Because many people with MPN work full-time, the flexibility of a home-based program was a major factor in their success.

Exercise can do more for patients than just physical strength

Patients who participated in the program reported feeling better in their daily lives. Many described a positive impact on symptoms like night sweats and fatigue. Many felt a sense of pride and hope, noting that the routine had a "soothing" or calming effect on their mood. Exercise gave people more confidence to join friends for activities they had previously avoided due to fear of their symptoms.

This research suggests that physical activity is a safe and helpful addition to standard medical treatments for myelofibrosis and other MPNs. While exercise does not replace medication, it can help manage the physical and emotional challenges of the disease. As scientists continue to study the long-term effects of exercise, these early results offer a practical way for patients to take an active role in their own health and recovery.

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Source: MPN-FIT: a randomized controlled pilot trial of supervised exercise in myeloproliferative neoplasms