Myeloma is not a single disease: The illuminating discovery and implications for care with Dr. Michael Kuehl, MD, PhD of the NCI
![Myeloma is not a single disease: The illuminating discovery and implications for care with Dr. Michael Kuehl, MD, PhD of the NCI image](https://healthtree.org/images-resize?width=1000&height=1000&imageUrl=https%253A%252F%252Ffirebasestorage.googleapis.com%252Fv0%252Fb%252Fhealthtree-production.appspot.com%252Fo%252Fgallery%25252Fpublic%25252FDr.%252520Michael%252520Kuehl_661580e1-c2ce-405e-bd64-38eead38ab44.jpg%253Falt%253Dmedia)
Myeloma is not a single disease: The illuminating discovery and implications for care with Dr. Michael Kuehl, MD, PhD of the NCI
Event Description
Learn about all myeloma happenings on the new Myeloma Crowd site: the first comprehensive site for myeloma patients and caregivers. Dr. Walter Michael Kuehl, MD, PhD Center for Cancer Research National Cancer Institute Interview date: April 25, 2014
Dr. Kuehl, in partnership with Dr. Bergsagel, discovered that myeloma is not a single disease. This significant discovery has led to great insights about what triggers myeloma growth, how each type of myeloma acts differently and the implications this has for future treatment approaches. Dr. Kuehl found 7 translocation types divided into three groups. In this interview, he shares how that discovery was made and what "primary" and "secondary" translocations mean. He describes how myeloma progresses in three steps 1)The appearance of MGUS 2)The transition from MGUS to active myeloma and 3)Myeloma proliferation. He shares the fact that when MGUS is compared with active myeloma, there is 3x more MYC present, suggesting that MYC could trigger MGUS to move to an active myeloma stage. He describes how MYC may not cause the cell growth, but give myeloma the autonomy to grow. Many of these translocation groups have overexpressed Cyclin D, but he describes how Cyclin D may make the cells more sensitive but on it's own is not enough to spur myeloma growth. He describes how to test for your myeloma's biology and stresses that the more patients know, the better care they will receive. He also tells us that patients can contribute to the treatment of their disease and help stimulate newer approaches with their unique perspective. He shares the opinion that the day of immunotherapies has arrived and advocates going to specialists who can provide the very best in myeloma care - and that means getting a second opinion when needed. We owe a debt of gratitude for his tireless efforts that have offered great insights into this complex disease. The live mPatient Myeloma Radio podcast with Dr. W. Michael Kuehl
Schedule & Agenda
Speakers & Moderators
![The panelist Jennifer Ahlstrom](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/community%2Fpublic%2Fshared%2FJenny%20Bio%20300x300.jpg?alt=media)
Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of the HealthTree Foundation.
Have Any Questions?
Thank you for your interest in the event. If you have any questions, we would love to help!
Feel free to give us a call or send us a message below.
Get In Touch With Us
1-800-709-1113
Support@healthtree.org
![newsletter icon](https://static.healthtree.org/icons/newsletter-icon.png)
Get the latest thought leadership on your Multiple Myeloma delivered straight to your inbox
Subscribe to the weekly newsletter for news, stories, clinical trial updates, and helpful resources and events with cancer experts.
Thanks to our HealthTree Community for Multiple Myeloma Sponsors:
![Johnson and Johnson](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FJohnson%20&%20Johnson%20Logo_64b18f59-85c9-4c20-a5ff-3842e69d8066.jpg?alt=media)
![Sanofi](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FSanofi%20updated%202023_d25a8d12-4f09-410c-9eb1-1e725b0b7c3e.jpg?alt=media)
![Pfizer](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FPfizer%20Logo%202024_50ae4587-5fdc-48e2-9a52-21651c643494.png?alt=media)
![Genentech](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/admin%2Fpublic%2Fshared%2FGenentech_Logo-700x182_e3c64168-dcf4-4540-9e9d-26500b26920a.png?alt=media)
![Regeneron](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FRegeneron_dec43aa4-fe53-4d5a-9b7f-4170101b47f9.webp?alt=media)
![Adaptive](https://firebasestorage.googleapis.com/v0/b/healthtree-production.appspot.com/o/gallery%2Fpublic%2FAdaptive%20Logo%204.2023_e0d11d37-8b31-4c88-a0fc-4d07efc9b16b.png?alt=media)