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During Blood Cancer Awareness Month, we're highlighting the impactful efforts of HealthTree Foundation in blood cancers. At HealthTree, we are dedicated to empowering patients with knowledge, connecting them to cutting-edge research, and fostering a supportive community.

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HealthTree Cure Hub: Accelerating Cures Through Patient-Driven Research

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At the heart of HealthTree's innovation is HealthTree Cure Hub, a platform that's revolutionizing blood cancer research. HealthTree Cure Hub connects patients directly to clinical trials, accelerating the development of new treatments. But it goes beyond trials. By gathering real-world data and patient-reported outcomes, HealthTree Cure Hub provides researchers with invaluable insights that are shaping the future of blood cancer care.

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Continue Exploring All the Benefits of HealthTree Cure Hub

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Real-World Impact: Examples of HealthTree Research

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HealthTree Foundation is actively contributing to blood cancer research. For example, a recent study reported on real-world experiences of patients undergoing some specific myeloma treatments, including the treatment decision-making process, patients' expectations and evaluation of treatment, and patient perspectives and information needs related to CAR T-cell therapies and bispecific antibodies.

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We also recently shared the results of the use of cannabis to manage pain and anxiety and the use of dietary supplements in patients with multiple myeloma, what motivates these patients to use supplements, and where they get their information about them.

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HealthTree Cure Hub is facilitating research in different stages of the treatment, such as the ongoing study on stem cell mobilization in patients undergoing a stem cell transplant. This research will help understand the challenges and hopefully improve the stem cell collection process for patients.

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Participate in Blood Cancer Research, Become a Cure Contributor

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HealthTree Cure Hub empowers patients to become active participants in research. By connecting your medical records, participating in surveys, and contributing to studies, you provide researchers with critical data that can lead to breakthroughs in blood cancer treatment.

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Create a free account and explore our open patient surveys here:

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JOIN/LOG IN TO HEALTHTREE CURE HUB

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!AD!

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Empowering Patients Through Knowledge and Connection

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At HealthTree, we understand that knowledge is power. Through our website and educational resources, HealthTree provides patients and their loved ones with trustworthy information about their specific blood cancer, treatment options, and managing side effects.

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But HealthTree is more than just information; it's a community. Through our online forums and webinars, patients can connect with others facing similar challenges, share experiences, and find support.

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Learn More About Blood Cancer

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HealthTree's Coach Program pairs newly diagnosed patients with trained volunteer coaches who have navigated similar diagnoses, providing personalized guidance and support.

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Join the HealthTree Community

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!AD!

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Expanding Support for All Blood Cancers

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While HealthTree Foundation began as a myeloma-focused organization, it has expanded its reach to support all blood cancers. We are currently most active in:

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!AD!

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We encourage all blood cancer patients and their loved ones to join our growing community. Together, we can make a difference.

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HealthTree Foundation: Innovation that saves lives

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B-cell lymphomas are a type of blood cancer representing the majority (80-85%) of non-Hodgkin lymphomas (NHLs). NHLs are a diverse group of blood cancers that affect immune cells known as lymphocytes, with different symptom patterns and responses to treatment. NHL usually originates in lymphoid tissues like lymph nodes or spleen and can spread to other organs.

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How Can Lymphoma Alter Your Bloodwork?

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When diagnosed with lymphoma or facing a relapse, blood work is a crucial part of monitoring the overall health. Blood tests can provide information about the body's condition and how lymphoma affects the normal body functions. In this article you’ll learn the most common alterations in blood work that lymphoma patients might experience, what each value means, normal ranges, and why these values can be altered.

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Complete Blood Count (CBC)

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A Complete Blood Count (CBC) is a common blood test that provides important information about the different cells that constitute your blood. Blood cells are produced in the bone marrow. When lymphoma cells invade the bone marrow, they can crowd our healthy bone marrow cells, making it difficult for the normal production of blood cells to occur. This is why patients with lymphoma often experience altered blood cell counts in their test results.

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White Blood Cells (WBC)

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Normal range: 3.2-10.6 k/ul
What it means: White blood cells are crucial for fighting infection. Lymphocytes and neutrophils are types of white blood cells.
Why it’s altered: Lymphoma can either increase WBC counts due to the overproduction of abnormal lymphocytes (lymphocytosis) or decrease WBC counts if the disease affects the bone marrow’s normal function (neutropenia). Due to the essential role of these cells in the immune system’s defenses, altered counts will always be linked to an increased risk of infection or an active infection.

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Red Blood Cells and Hemoglobin (Hb)

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Normal range: 12.1-15.9 g/dL
What it means: Hemoglobin is the protein in red blood cells (erythrocytes) that carries oxygen throughout your body.
Why it’s altered: Lymphoma cells invading the bone marrow can decrease the production of red blood cells, leading to lower hemoglobin levels, which is commonly known as anemia.

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Platelets

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Normal range: 150 - 440 k/ul
What it means: Platelets are fragments of a cell called megakaryocyte that circulate in the blood and play a crucial role in blood clotting and wound healing.
Why it’s altered: If lymphoma affects the bone marrow, it can result in a low platelet count, known as thrombocytopenia, which can lead to an increased risk of bleeding and bruising.

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What is Other Blood Tests Can Detect Lymphoma?

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Lactate Dehydrogenase (LDH)

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Normal range: 100 - 253 or 300 - 600 U/L
What it means: LDH is an enzyme found in almost all body tissues, and high levels can indicate tissue damage. The range varies greatly in this lab value for many reasons: each laboratory has a different range for what's considered normal. Your lab report should show the range that your lab uses for each test. Another reason is that your doctor will look at your results and, based on age, health, and other factors, will make a full-picture interpretation of what might be happening in your body. A value that isn't in the normal range may still be normal for you.
Why it’s altered: Elevated LDH levels are common in lymphoma patients and can indicate the presence and extent of disease and be a marker of tumor burden.

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Erythrocyte Sedimentation Rate (ESR)

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Normal range: 0 to 22 mm/hr for men, 0 to 29 mm/hr for women, but it gradually increases with age.
What it means: ESR is a test that indirectly measures the amount of inflammation in the body. It measures the rate at which the red blood cells, or erythrocytes, fall to the bottom of a blood sample tube.
Why It’s altered: Elevated ESR can be seen in lymphoma due to the inflammatory response caused by the disease.

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Beta-2 Microglobulin (β2M)

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Normal range: 0.70 to 1.80 mg/L
What It means: Beta-2 microglobulin is a protein found on most cells' surfaces, but some, particularly lymphocytes, release it into the blood. β-2 microglobulin is usually elevated in some cancers, inflammation diseases, and kidney disease.
Why it’s altered: In lymphoma, high levels of β-2 microglobulin can indicate a higher number of lymphoma cells or tumor burden, making it a useful marker for diagnosis and prognosis.

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Liver Function Tests (LFTs)

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What they mean: These tests assess liver function.
Why they’re altered: Abnormal levels can indicate that lymphoma cells are invading the liver. Side effects from some treatments can also produce changes in liver function.

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Liver function tests measure the levels of enzymes and proteins in the blood produced by the liver. They are an indicator of the liver health status and they can also alert if there are obstructions in the biliary tract. The indicators for liver functions are:

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Alanine aminotransferase (ALT): is an enzyme that can be elevated when the liver is damaged by viral infection, fibrosis (cirrhosis), non-alcoholic steatohepatitis, also known as fatty liver, and drug toxicity. In rarer cases, it can also be elevated when there are muscle injuries from trauma or excessive exercise. \n\n\t
- Normal range: 7 to 56 units per liter
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Aspartate aminotransferase (AST): is also an enzyme used to measure liver health, however, it is less specific because it can be found in other tissues. \n\t
- Normal range: 10 to 40 units per liter
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Alkaline phosphatase (ALP): is an enzyme that also helps determine the functioning of the liver and gallbladder or identify concerns with the bones. Its function in the body is important in calcium metabolism. It can also be helpful as an infection or inflammation indicator.\n\t
- Normal range: 44 to 147 units per liter
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Bilirubin: It is the product of red blood cell metabolism, and it also helps break down food in the digestive system. It has a yellow color, and high bilirubin levels can alter the skin color and make it yellow. In more severe cases it can also tint the eyes yellow; this condition is called jaundice. When bilirubin levels are low, it can produce a rare condition called acholia, where the stool is white instead of brown, and choluria, when the urine color is black as a cola soda. This can happen when there is a bile tract obstruction.\n\t
- Normal range: 0.1 to 1.2 milligrams per deciliter
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Monitoring blood work is essential for managing lymphoma. Understanding these common alterations can help you navigate your health status and engage in more informed discussions with your healthcare team. Consult your healthcare provider to interpret your results and develop a personalized care plan.

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Take control of your care with HealthTree Cure Hub!

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With HealthTree, you can continue learning about lymphoma, discover treatment options, find a specialist or a clinical trial, and so much more! Sign up for a free patient account today to get started.

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CREATE MY FREE ACCOUNT

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Sources:

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https://emedicine.medscape.com/article/202677-overview#a2
https://healthtree.org/myeloma/community/resources
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Follicular lymphoma is the most common slow-growing lymphoma affecting adults today. In the U.S., approximately 14,000 new cases are diagnosed each year, with a median age at diagnosis in the early 60s.

Analyzing the risk factors contributing to follicular lymphoma is essential to better understanding how to prevent its progression. Clinical studies, in addition to looking for new treatment options, also help researchers understand other aspects of diseases. That’s why a recent study analyzed patient data from eight clinical trials, totaling 2,428 patients with follicular lymphoma. Although this is still a small sample compared to the number of newly diagnosed patients each year, the findings offer valuable insights into the risk factors influencing patient outcomes.

What Did the Study Analyze?

The two-year study obtained data from 2,428 patients with the following results:

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26.5% of patients experienced disease progression within two years
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3.4% of patients passed from follicular lymphoma
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1.4% of patients passed away from other causes
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The primary cause of death for patients is the lymphoma itself or the adverse events associated with therapy
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Prolonged disease-free survival is still achieved by a considerable proportion of patients with follicular lymphoma, who face risks based on other chronic illnesses and age.
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What Contributes to Follicular Lymphoma Progression?

This study highlights the importance of understanding clinical factors at diagnosis that can help predict disease progression and survival outcomes. The findings shed light on the need for personalized treatment planning based on the following risk factors:

Physical factors

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Gender: Male patients, with more than four affected lymph nodes, are more likely to have disease progression
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Age and health status: Patients older than 70 years old and patients with comorbidities had an increased risk of death from both lymphoma and other causes.
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Abnormal Blood tests

These include LDH, hemoglobin and β2-microglobulin, all explained below.

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Lactate dehydrogenase (LDH): it is an inflammation marker in blood; when elevated, it can increase the risk of disease progression
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Low hemoglobin is also associated with a higher risk
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Increased β2-microglobulin levels face a higher risk of progression
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What Prevents Follicular Lymphoma Progression?

The study analysis also found factors that helped prevent follicular lymphoma progression; one of them is rituximab therapy, a CD20-targeting agent, which significantly reduced progression risks by 71%, decreased deaths from follicular lymphoma to 95%, and reduced 87% deaths for other causes.

While there is no absolute cure yet for follicular lymphoma, there are treatments that can effectively manage the disease and improve quality of life. Treatment options depend on the stage and symptoms, ranging from watchful waiting to therapies like rituximab or chemotherapy like R-CHOP or bendamustine.

Participating in clinical trials accelerates research and prevents progression. When a patient’s progression can be tracked through various treatment circumstances, the information obtained is essential for assessing long-term outcomes in follicular lymphoma patients.

Why Is Analyzing Risk Important to Me as a Follicular Lymphoma Patient?

Analyzing your risk as a follicular lymphoma patient is important because recognizing your specific risk factors can guide you in seeking early medical attention and exploring personalized treatment options with your healthcare team.

Understanding your risks may also help you identify and qualify for clinical trials offering additional treatment opportunities. By discussing these factors with your healthcare team, you can make informed decisions, which can significantly influence the progression of the disease and improve your overall outcomes.

Join the HealthTree for follicular lymphoma community and participate in our comprehensive free webinars, where we invite professionals to answer your questions!

Don’t miss our upcoming webinar, “Caring for the Caregiver: Effective Stress Management Strategies,” which will equip you with actionable insights to reduce stress, improve your quality of life, and enhance your caregiving experience.

Source:

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265299/
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