Cytokine release syndrome (CRS): fever, low blood pressure, difficulty breathing, chills, severe nausea, vomiting, diarrhea, muscle or joint pain
Infections (bacterial, viral, fungal)
Hypogammaglobulinemia (low antibody levels)
Fever
Decreased appetite
Headache
Febrile neutropenia (fever with low white blood cell count)
Bleeding
Musculoskeletal pain
Vomiting
Encephalopathy (confusion, altered mental status)
Diarrhea
Hypotension (low blood pressure)
Cough
Nausea
Pain
Hypoxia (low oxygen)
Tachycardia (fast heart rate)
Edema (swelling)
Fatigue
Acute kidney injury

Other possible side effects include prolonged low blood counts (cytopenias), neurological toxicities (such as seizures, confusion, or difficulty speaking), and secondary cancers.

tisagenlecleucel

Common brand names

Approved use in