What is Systemic Anaplastic Large-Cell Lymphoma?

Systemic Anaplastic Large-Cell Lymphoma (ALCL) is a type of non-Hodgkin lymphoma that primarily affects the lymph nodes. It is characterized by the abnormal growth of T-cells, a type of white blood cell. ALCL is further classified into two subtypes: ALK-positive and ALK-negative, based on the presence or absence of a protein called anaplastic lymphoma kinase (ALK). The disease can occur at any age, but it is more common in children and young adults. Symptoms may include fever, weight loss, and night sweats, as well as swollen lymph nodes in the neck, armpit, or groin.

Types of Systemic Anaplastic Large-Cell Lymphoma

There are two main types of Systemic Anaplastic Large-Cell Lymphoma: ALK-positive and ALK-negative. The ALK-positive type is associated with a chromosomal abnormality that leads to the production of an abnormal ALK protein. This type is more common in children and young adults and generally has a better prognosis. The ALK-negative type does not have the chromosomal abnormality and is more common in older adults. The prognosis for ALK-negative ALCL is generally poorer than for the ALK-positive type.

Why do people get Systemic Anaplastic Large-Cell Lymphoma?

The exact cause of Systemic Anaplastic Large-Cell Lymphoma is not known. However, it is believed to be related to genetic mutations, particularly those involving the ALK gene in ALK-positive cases. These mutations lead to the production of abnormal proteins that promote the uncontrolled growth of T-cells, leading to the development of the disease. Other risk factors may include a weakened immune system, exposure to certain chemicals and radiation, and certain viral infections. However, more research is needed to fully understand the causes and risk factors for this disease.

Who gets Systemic Anaplastic Large-Cell Lymphoma?

According to the National Cancer Institute, there will be an estimated ___ new cases of Systemic Anaplastic Large-Cell Lymphoma in 2023, making up ___% of all new cancer diagnoses. In 2020, there were an estimated ___ people living with Systemic Anaplastic Large-Cell Lymphoma in the United States. (you get this info from the NCI’s SEER data. Add the link to this data as a hyperlink on the text “National Cancer Institute”

Want to Learn More About Systemic Anaplastic Large-Cell Lymphoma?

Keep reading HealthTree for Systemic Anaplastic Large-Cell Lymphoma's 101 pages!

• How Is Systemic Anaplastic Large-Cell Lymphoma Diagnosed?
• How Long Will I Live With Systemic Anaplastic Large-Cell Lymphoma?
• What Are The Signs And Symptoms Of Systemic Anaplastic Large-Cell Lymphoma?
• How Is Systemic Anaplastic Large-Cell Lymphoma Staged And Classified?
• What Are Treatments For Systemic Anaplastic Large-Cell Lymphoma?