What Are Treatments For Myeloproliferative Neoplasm?

Myeloproliferative neoplasms (MPNs) are a group of diseases that affect the bone marrow and lead to an increased production of blood cells. These conditions are chronic and progressive, and while they cannot be cured, there are several treatment options available to manage symptoms and slow the progression of the disease. The choice of treatment depends on the specific type of MPN, the patient's age, overall health, and the presence of any symptoms or complications.

1. Watchful Waiting

For patients with slow-progressing MPNs and no symptoms, a watchful waiting approach may be recommended. This involves regular monitoring of the patient's condition without active treatment, until symptoms develop or changes in the blood are detected. This approach avoids unnecessary side effects from treatments.

2. Drug Therapy

Drug therapy is often used to manage symptoms and slow the progression of MPNs. The specific drugs used depend on the type of MPN. For example:

• Hydroxyurea: This is commonly used to treat polycythemia vera and essential thrombocythemia. It works by slowing the production of blood cells.
• Interferon alfa: This can be used to treat several types of MPNs. It helps to regulate the immune system and slow the production of blood cells.
• Ruxolitinib: This is used to treat myelofibrosis and polycythemia vera. It works by blocking the action of certain proteins that cause the body to produce too many blood cells.

3. Phlebotomy

Phlebotomy is a procedure used to remove excess blood from the body. This can help to reduce symptoms and complications in conditions such as polycythemia vera, where too many red blood cells are produced.

4. Stem Cell Transplant

In some cases, a stem cell transplant may be considered. This is the only potential cure for MPNs, but it carries significant risks and is usually only considered for younger patients with advanced disease. The procedure involves replacing the patient's bone marrow with healthy stem cells from a donor.

5. Radiation Therapy

Radiation therapy uses high-energy rays to kill cancer cells. It may be used in some cases to shrink an enlarged spleen in myelofibrosis.

6. Clinical Trials

Clinical trials are not just a last resort for treating MPNs. They can actually provide access to cutting-edge treatments that are not yet approved but show promise over years of testing. The choice of a clinical trial depends on a variety of factors including the patient's age, overall health, the type of MPN, and genetic changes in the leukemia cells. It's important to discuss all treatment options, including goals and possible side effects, with your healthcare team to help make the best decision. 

To learn more about your clinical trial options, visit HealthTree's Clinical Trial Finder. Utilize the advanced filter option to locate trials that you are eligible to participate in. You can create a HealthTree account to favorite your top trial options so you can discuss them with your ALL specialist.

Want to Learn More About Myeloproliferative Neoplasm?

Keep reading HealthTree for Myeloproliferative Neoplasm's 101 pages!

• What Is Myeloproliferative Neoplasm?
• How Is Myeloproliferative Neoplasm Diagnosed?
• How Long Will I Live With Myeloproliferative Neoplasm?
• What Are The Signs And Symptoms Of Myeloproliferative Neoplasm?
• How Is Myeloproliferative Neoplasm Staged And Classified?