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The MYC Problem in Myeloma: Dr. Jay Bradner, MD, Dana Farber Cancer Institute and Bradner Lab
The MYC Problem in Myeloma: Dr. Jay Bradner, MD, Dana Farber Cancer Institute and Bradner Lab image
HealthTree Podcast for Multiple Myeloma
event Aug 30, 2014 / 11:00AM MDT

Event Description

Learn about all myeloma happenings on the new Myeloma Crowd site: the first comprehensive site for myeloma patients and caregivers. Dr. James (Jay) Bradner, MD Dana Farber Cancer Institute Bradner Lab Interview Date: August 30, 2014

 Dr. Jay Bradner describes how Myc works as the master regulator of cell growth in myeloma and other cancers. Because all roads lead to Myc, it is an attractive  target that begs inhibitors. He discusses this Myc problem in detail and shares how the therapeutics technologies we have today are not suitable to drug Myc. He describes three ways to target Myc 1) Find out what turns Myc on 2) Target Myc collaborators and 3) Create new technologies to drug Myc. He describes the exciting detail behind the creation of JQ1, a Bromodomain inhibitor (BRD4) by Jun Qi and how they used a rare open source platform to help develop the molecule. BRD4 is a Myc collaborator and targeting it has shown success in a mouse model.  He shares that discovering a new molecule is easier and faster than turning it into a real drug that can be used in-clinic, but this new BRD4 inhibitor (now called TEN-010) is being used in Phase I clinical trials. He notes importantly, "Time is our enemy. We must be as creative with our scientific strategies as we are with our science." The live mPatient Myeloma Radio podcast with Dr. Jay Bradner, MD

Schedule & Agenda

Dr. Jay Bradner & Jennifer Ahlstrom

Speakers & Moderators

The panelist Jennifer Ahlstrom
Jennifer Ahlstrom

Myeloma survivor, patient advocate, wife, mom of 6. Believer that patients can help accelerate a cure by weighing in and participating in clinical research. Founder of the HealthTree Foundation.

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