Common side effects of avapritinib can vary depending on the condition being treated:

For gastrointestinal stromal tumors (GIST):

Edema (swelling)
Nausea
Fatigue or weakness
Cognitive impairment (memory issues, confusion)
Vomiting
Decreased appetite
Diarrhea
Increased tearing
Abdominal pain
Constipation
Rash
Dizziness
Hair color changes

For advanced systemic mastocytosis (AdvSM):

Edema
Diarrhea
Nausea
Fatigue or weakness

For indolent systemic mastocytosis (ISM):

Eye edema
Dizziness
Peripheral edema
Flushing

Other serious but less common side effects include intracranial hemorrhage (bleeding in the brain) and cognitive effects. Photosensitivity (sensitivity to sunlight) can also occur.

Avapritinib

Common brand names

Approved use in