How it is administered

Chlorambucil is administered orally in the form of tablets. Each tablet typically contains 2 mg of chlorambucil. The medication is taken by mouth, and the entire daily dose may be given at one time. It is important to follow your doctor’s instructions regarding the dose and schedule.

How it works

Chlorambucil is a type of chemotherapy known as an alkylating agent. It works by interfering with the DNA replication process in cancer cells. Specifically, chlorambucil attaches alkyl groups to the DNA within the cell, which damages the DNA and prevents the cells from dividing and growing. This action triggers cell death (apoptosis), especially in rapidly dividing cells such as cancer cells.

Chlorambucil is particularly effective in blood cancers because these diseases often involve cells that multiply quickly. By disrupting their DNA, chlorambucil helps to slow down or stop the progression of the disease. However, because it also affects normal cells that divide rapidly, such as those in the bone marrow, it can lead to side effects like low blood counts.

Who Should take it

Chlorambucil is indicated for the treatment of certain blood cancers, including chronic lymphocytic leukemia (CLL) and malignant lymphomas such as lymphosarcoma, giant follicular lymphoma, and Hodgkin’s disease. It is used to help control these diseases and can provide relief from symptoms, though it is not considered a cure.

Your doctor may recommend chlorambucil if you have one of these conditions and other treatments are not suitable or have not been effective. It is important to have regular blood tests and medical supervision while taking this medication.

Who should not take it

Chlorambucil should not be used in patients who have previously shown resistance to the medication or who have had an allergic reaction to it. There may also be cross-reactions with other alkylating agents, so caution is needed if you have had hypersensitivity to similar drugs.

It should not be given to patients with conditions other than chronic lymphocytic leukemia or malignant lymphomas due to its carcinogenic properties. Women who are pregnant or may become pregnant should avoid this medication, as it can cause harm to the unborn baby. Always inform your doctor about your medical history and any allergies before starting treatment.

Commonly used with

Chlorambucil may be used alone or in combination with other medications for blood cancers. It is sometimes given alongside other chemotherapy agents or, in certain cases, with palliative radiation therapy to help control symptoms. The specific combination will depend on your disease and your doctor’s recommendations.

Commonly tested with

Chlorambucil has been tested in combination with other chemotherapeutic agents and with radiation therapy in clinical studies for blood cancers. The choice of combination is based on the type of blood cancer and the patient’s overall health. Your treatment team will determine the best approach for your individual situation.