A non-chemo treatment combination of zanubrutinib (Brukinsa) and obinutuzumab (Gazyva) evaluated in the ROSEWOOD study showed promising results for helping many follicular lymphoma patients whose disease had come back after remission or the cancer cells had stopped responding to treatment achieve a reduction of cancer signs and symptoms. Read more about the study’s findings below.
Zanubrutinib is a non-chemo targeted therapy administered orally that helps kill follicular lymphoma cells. It works by blocking a molecule (Bruton’s tyrosine kinase [BTK]) on the surface of the cancer cell which plays a role in telling the cell to stay alive and keep making new cells. By blocking the BTK receptor, the cancerous B-cell dies. Zanubrutinib is currently available for the treatment of follicular lymphoma patients in clinical trials.
Obinutuzumab is a type of medicine called a monoclonal anti-CD20 antibody. It is administered by infusion and binds to protein CD20 on the surface of B-cells. Binding to the CD20 protein helps kill the follicular lymphoma cells. Obinutuzumab is currently FDA-approved for the treatment of follicular lymphoma.
The ROSEWOOD study investigated whether adding zanubrutinib in combination with obinutuzumab could create a more effective treatment outcome for relapsed and refractory follicular lymphoma patients compared to treating the cancer with obinutuzumab alone.
217 relapsed/refractory follicular lymphoma patients from 17 different countries were split 2 to 1 into the treatment groups. Two-thirds of the patients received zanubrutinib with obinutuzumab. The remaining one-third received obinutuzumab by itself. The therapies were administered over the course of two years.
The most common side effects of the zanubrutinib and obinutuzumab combination included low platelet count (thrombocytopenia), pneumonia, and diarrhea. Patients worked with their healthcare team to help reduce these side effects.
The findings of the ROSEWOOD study offer promising treatment results of a new non-chemo targeted therapy combination for relapsed and refractory follicular lymphoma patients. We are grateful for the doctors and patients who participate in cancer research to help accelerate cures and improve the quality of life for those living with blood cancer.
Want to help accelerate a cure for follicular lymphoma? Get involved in research to support the next best treatment options for patients!
A non-chemo treatment combination of zanubrutinib (Brukinsa) and obinutuzumab (Gazyva) evaluated in the ROSEWOOD study showed promising results for helping many follicular lymphoma patients whose disease had come back after remission or the cancer cells had stopped responding to treatment achieve a reduction of cancer signs and symptoms. Read more about the study’s findings below.
Zanubrutinib is a non-chemo targeted therapy administered orally that helps kill follicular lymphoma cells. It works by blocking a molecule (Bruton’s tyrosine kinase [BTK]) on the surface of the cancer cell which plays a role in telling the cell to stay alive and keep making new cells. By blocking the BTK receptor, the cancerous B-cell dies. Zanubrutinib is currently available for the treatment of follicular lymphoma patients in clinical trials.
Obinutuzumab is a type of medicine called a monoclonal anti-CD20 antibody. It is administered by infusion and binds to protein CD20 on the surface of B-cells. Binding to the CD20 protein helps kill the follicular lymphoma cells. Obinutuzumab is currently FDA-approved for the treatment of follicular lymphoma.
The ROSEWOOD study investigated whether adding zanubrutinib in combination with obinutuzumab could create a more effective treatment outcome for relapsed and refractory follicular lymphoma patients compared to treating the cancer with obinutuzumab alone.
217 relapsed/refractory follicular lymphoma patients from 17 different countries were split 2 to 1 into the treatment groups. Two-thirds of the patients received zanubrutinib with obinutuzumab. The remaining one-third received obinutuzumab by itself. The therapies were administered over the course of two years.
The most common side effects of the zanubrutinib and obinutuzumab combination included low platelet count (thrombocytopenia), pneumonia, and diarrhea. Patients worked with their healthcare team to help reduce these side effects.
The findings of the ROSEWOOD study offer promising treatment results of a new non-chemo targeted therapy combination for relapsed and refractory follicular lymphoma patients. We are grateful for the doctors and patients who participate in cancer research to help accelerate cures and improve the quality of life for those living with blood cancer.
Want to help accelerate a cure for follicular lymphoma? Get involved in research to support the next best treatment options for patients!
about the author
Megan Heaps
Megan joined HealthTree in 2022. As a writer and the daughter of a blood cancer patient, she is dedicated to helping patients and their caregivers understand the various aspects of their disease. This understanding enables them to better advocate for themselves and improve their treatment outcomes. In her spare time, she enjoys spending time with her family, sewing, and cooking.
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