What are the Signs and Symptoms of Diffuse Large B Cell Lymphoma?

Diffuse large B cell lymphoma (DLBCL) is a fast-growing lymphoma that affects B-lymphocytes, which are immune cells that play a crucial role in creating antibodies to fight infections. The symptoms of DLBCL can vary greatly from person to person, but understanding the early signs and symptoms of DLBCL can lead to faster diagnosis and better treatment outcomes.

What is the First Sign of DLBCL?

The first sign of DLBCL is often a quickly growing, non-painful mass, typically an enlarged lymph node in the neck, groin, or abdomen. This swelling might be noticed suddenly and can develop rapidly over a short period. DLBCL commonly affects more than lymph nodes, which include the brain, bones, kidneys, adrenal glands, and other soft tissues.

What are the Most Common Signs and Symptoms of Diffuse Large B Cell Lymphoma?

• Swollen lymph nodes: The lymph nodes in the neck, armpit, or groin may become enlarged and may or may not be painful.
• Fever: A person with DLBCL may have unexplained fevers, often higher than 38°C (100.4°F).
• Night sweats: These are often drenching sweats that require a person to change their clothes in the middle of the night.
• Weight loss: Unexplained weight loss of 10% or more of the body weight over a period of six months is another common symptom.
• Fatigue: People with DLBCL often feel very tired and have a lack of energy.
• Shortness of breath or cough: If the lymphoma is in the chest, it can press on the windpipe (trachea), which can cause coughing or trouble breathing.
• Abdominal pain or swelling: If the lymphoma is in the abdomen, it can cause the belly to feel full or swollen.

How Does DLBCL Differ Between Advanced and Localized Disease?

Understand the different stages of DLBCL, the symptoms may vary depending on the stage. Learn all about it in our comprehensive article about staging and classification of DLBCL.

• Advanced Disease: Approximately 60% of people are not diagnosed with DLBCL until it has reached an advanced stage (stage III or IV). This means the cancer has spread widely, often involving multiple lymph node regions or other organs.

• Localized Disease: In the remaining 40% of cases, DLBCL is confined to one side of either above or below the diaphragm, and this is referred to as localized disease. Early detection of this can lead to more targeted treatment options.

Why Should You See a Doctor if You Have These Symptoms?

These symptoms can be caused by various conditions, not just DLBCL. Seeing a healthcare professional for an accurate diagnosis is crucial for determining the appropriate treatment and achieving the best possible outcomes. Early medical intervention can also help manage symptoms effectively and improve your quality of life.

How Can Treatment Improve DLBCL Symptoms?

Medical attention can help manage and alleviate your symptoms and side effects. Doctors can tailor a DLBCL treatment plan that allows you to live as comfortably as possible. They can adjust treatment as needed and provide supportive care to manage treatment-related side effects and complications. To know more about DLBCL treatments you can visit our comprehensive 101 page What are Treatments for DLBCL?.

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Source: 

• https://www.uptodate.com/contents/diffuse-large-b-cell-lymphoma-in-adults-beyond-the-basics/print#:~:text=The%20first%20sign%20of%20DLBCL,night%20sweats%2C%20or%20other%20symptoms.