Muscle, joint, and bone pain are common for people living with lymphoma, especially after CAR-T. There are several reasons why this can happen:

• Bone marrow involvement. Lymphoma cells can collect in the bone marrow, causing pain in the bones and joints.
• Side effects from treatment. CAR-T can increase inflammation, leading to soreness in muscles and joints.
• Other health issues. Conditions like arthritis or osteoporosis may also cause joint or bone pain in people with lymphoma.
• Fatigue. Tiredness from CAR-T or the cancer itself can sometimes lead to body aches and muscle discomfort.

How to manage pain after CAR-T for lymphoma

There are several ways to reduce muscle, joint, or bone pain and improve comfort:

Medications

• Prescription pain medicines or anti-inflammatory treatments may be prescribed by your doctor.
• Topical ointments and patches that you can get at your local pharmacy can provide some relief, but should be discussed with your medical team before use. 
• Bone-strengthening medications may be used if needed.
• It is important not to use tylenol or NSAIDs (such as ibuprofen, aspirin, or naproxen) unless first discussed with your health care team as these medications can mask a fever or infection and impact the function of platelets in your blood.

Physical therapy and movement

• Try gentle stretches and exercises to improve strength and flexibility.
• A physical therapist can show you safe movements to reduce pain and stiffness.

Supportive therapies

• Use warm or cold packs to ease sore areas.
• Make ergonomic changes at home, like using supportive chairs or cushions to protect your joints. 

Complementary therapies

• Consider acupressure to relieve pain without medication.
• Massage therapy can help relax tight muscles. Be sure to let your massage therapist know that you are on cancer treatment and may have low blood counts.
• Try gentle mind-body practices like yoga, meditation, or breathing exercises
• Some people may benefit from magnesium supplements—talk to your CAR T-cell therapy and health care teams before starting any new supplement. 

Healthy habits

• Rest when your body needs it.
• Drink plenty of water to stay hydrated.

Reduce inflammation

• Eat more anti-inflammatory foods, like fruits, vegetables, nuts, and fish.
• Light physical activity, when safe, may also help lower inflammation over time.