There are no absolute contraindications listed for pralatrexate, meaning there are no specific situations where it should never be used. However, certain patients should use caution:

If you have severe kidney problems (end stage renal disease), pralatrexate should generally be avoided unless the potential benefits outweigh the risks, as it can increase toxicity.
Pralatrexate can cause harm to an unborn baby, so it should not be used during pregnancy. Effective contraception is recommended for both men and women during treatment and for several months after the last dose.
If you are breastfeeding, you should not breastfeed during treatment and for at least 1 week after the last dose.

Always inform your healthcare provider about all your medical conditions and medications before starting pralatrexate.

pralatrexate

Common brand names

Approved use in