Dr. David Bond, an Assistant Professor in the Division of Hematology at Ohio State University, recently presented collaborative research with Nationwide Children's Hospital, addressing a critical question in the area of lymphoma treatment. The study focused on young adult patients with mature B-cell lymphomas, like DLBCL, comparing treatment outcomes at adult and pediatric centers.
In medical systems, patients typically transition from pediatric to adult centers around the age of 18. However, Dr. Bond and his team recognized that the treatment approaches for diseases like DLBCL differ significantly between adult and pediatric centers. This prompted the investigation into whether these differences translate into variations in side effects or outcomes for younger patients.
This study included patients aged 12-39 years at diagnosis who were treated between 2011 and 2023 at Ohio State University Comprehensive Care Center (in the adult group) and Nationwide Children’s Hospital (in the pediatric group). All patients had aggressive mature B-cell lymphomas. Diagnoses included diffuse large B-cell lymphoma (DLBCL), double hit lymphoma (DHL), Burkitt lymphoma (BL), primary mediastinal B-cell lymphoma (PMBCL), grey zone lymphoma (GZL), and unclassifiable high-grade B-cell lymphoma (HGBCL).
Out of 180 patients, 156 adults were treated at Ohio State and the remaining 24 pediatric patients were treated at Nationwide Children’s Hospital. The median age was 30 years old. There were more males than females in both groups. A variety of standard treatments were received by the participants.
Notably, the findings revealed substantial differences in treatments, particularly for patients with DLBCL. These findings are summarized below:
Importantly, despite these differences in treatment techniques and side effects, the study did not identify significant differences in the success of the treatments. Both adult and pediatric approaches led to good outcomes overall, emphasizing that the primary goal of effective treatment was achieved in both settings.
The research by Dr. Bond and his team serves as a crucial step toward comprehensively understanding the implications of treatment sites on patient experiences and outcomes. The study not only highlights the effectiveness of these treatments but also emphasizes the need to address and manage side effects. These findings could inform future treatment strategies and contribute to refining the standard of care for young adult patients with mature B-cell lymphomas, like DLBCL, transitioning from pediatric to adult centers.
Dr. David Bond, an Assistant Professor in the Division of Hematology at Ohio State University, recently presented collaborative research with Nationwide Children's Hospital, addressing a critical question in the area of lymphoma treatment. The study focused on young adult patients with mature B-cell lymphomas, like DLBCL, comparing treatment outcomes at adult and pediatric centers.
In medical systems, patients typically transition from pediatric to adult centers around the age of 18. However, Dr. Bond and his team recognized that the treatment approaches for diseases like DLBCL differ significantly between adult and pediatric centers. This prompted the investigation into whether these differences translate into variations in side effects or outcomes for younger patients.
This study included patients aged 12-39 years at diagnosis who were treated between 2011 and 2023 at Ohio State University Comprehensive Care Center (in the adult group) and Nationwide Children’s Hospital (in the pediatric group). All patients had aggressive mature B-cell lymphomas. Diagnoses included diffuse large B-cell lymphoma (DLBCL), double hit lymphoma (DHL), Burkitt lymphoma (BL), primary mediastinal B-cell lymphoma (PMBCL), grey zone lymphoma (GZL), and unclassifiable high-grade B-cell lymphoma (HGBCL).
Out of 180 patients, 156 adults were treated at Ohio State and the remaining 24 pediatric patients were treated at Nationwide Children’s Hospital. The median age was 30 years old. There were more males than females in both groups. A variety of standard treatments were received by the participants.
Notably, the findings revealed substantial differences in treatments, particularly for patients with DLBCL. These findings are summarized below:
Importantly, despite these differences in treatment techniques and side effects, the study did not identify significant differences in the success of the treatments. Both adult and pediatric approaches led to good outcomes overall, emphasizing that the primary goal of effective treatment was achieved in both settings.
The research by Dr. Bond and his team serves as a crucial step toward comprehensively understanding the implications of treatment sites on patient experiences and outcomes. The study not only highlights the effectiveness of these treatments but also emphasizes the need to address and manage side effects. These findings could inform future treatment strategies and contribute to refining the standard of care for young adult patients with mature B-cell lymphomas, like DLBCL, transitioning from pediatric to adult centers.
about the author
Kat Richardson
Kat is from Lehi, Utah and is the education manager for lymphoma. She has worked in healthcare for a decade now, and earned her degree in community health education and promotion. Kat is passionate about disease prevention as well as improving quality of life and health equity. She enjoys reading, hiking, baking, ice skating, gardening, time with her family and friends, and most of all, spoiling her nieces and nephew.
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