Pegylated interferon alfa-2a is a modified form of a naturally occurring protein called interferon, which is produced by the body in response to infections. The 'pegylated' part means the molecule has been attached to polyethylene glycol, which helps it stay in the body longer, allowing for once-weekly dosing.

This medication works by stimulating the immune system to fight viruses and abnormal cells, such as cancer cells. It binds to specific receptors on the surface of cells, activating pathways inside the cell that help control the growth of viruses and cancer. These pathways can also increase the production of proteins that help the immune system recognize and destroy infected or abnormal cells. While pegylated interferon alfa-2a is mainly approved for certain viral infections, its immune-stimulating effects have been explored in blood cancers, including some lymphomas and leukemias.

Pegylated Interferon Alfa-2a

Common brand names

Approved use in