What Is Myeloproliferative Neoplasm?

Myeloproliferative Neoplasms (MPNs) are a group of rare, chronic blood cancers in which the bone marrow, the body's blood cell factory, produces too many red blood cells, white blood cells, or platelets. These conditions are caused by mutations in the DNA of cells in the bone marrow. The overproduction of blood cells by the marrow can lead to thicker blood and an increased risk of forming clots, which can cause serious health problems such as strokes and heart attacks.

Why do people get Myeloproliferative Neoplasm?

The exact cause of MPNs is not known, but they are thought to result from mutations in the DNA of cells in the bone marrow. These mutations can be inherited (passed on from parents to children) or acquired (occurring after birth). Some MPNs, such as CML (chronic myeloid leukemia), are associated with specific genetic changes, such as the Philadelphia chromosome. However, the cause of most MPNs remains unknown. Risk factors for developing an MPN include being over the age of 60, being male, and having a family history of the disease. 

Who gets Myeloproliferative Neoplasm?

MPNs can affect people of any age, but they are most common in adults over 60. More than 200,000 people in the United States are estimated to be living with an MPN. This group of cancers develops slowly. Patients often live with their disease for years before noticing any symptoms. Your age and sex are the most significant predictors of how likely you are to have a myeloproliferative neoplasm.

Want to Learn More About Myeloproliferative Neoplasm?

Keep reading HealthTree for Myeloproliferative Neoplasm's 101 pages!

• How Is Myeloproliferative Neoplasm Diagnosed?
• How Long Will I Live With Myeloproliferative Neoplasm?
• What Are The Signs And Symptoms Of Myeloproliferative Neoplasm?
• How Is Myeloproliferative Neoplasm Staged And Classified?
• What Are Treatments For Myeloproliferative Neoplasm?